Patrick S Beaty

US Patent:

20030111607, Jun 19, 2003

Filed:

Jun 26, 2001

Appl. No.:

09/892061

Inventors:

Nicholas Bachur - Monkton MD, US
Patrick Beaty - Felton PA, US
Timothy Foley - Forest Hill MD, US

International Classification:

G01N021/84

US Classification:

250/343000, 435/034000

Abstract:

A system and method employing infrared laser spectrography and dual wavelength modulation to monitor the concentration of a gas, such as oxygen or carbon dioxide, in the sample vial, or to monitor the pressure in the sample vial, to thus detect for microorganism growth in the sample vial. The system and method each employ an energy emitting device, such as an infrared laser, a detector and a signal analyzer, such as a spectroscopy device. The infrared laser emits toward the container infrared energy having a substantially single wavelength substantially equal to a wavelength at which the gas absorbs the infrared energy. The detector detects a portion of the energy signal that passes through the container, and the signal analyzer spectroscopically analyzes the detected portion of the energy signal to determine whether the gas exists in the container, or to determine the pressure in the container. The system and method thus determines whether an organism or cell of interest is present or viable in the container based on the results of the gas or pressure detection.

US Patent:

20110029249, Feb 3, 2011

Filed:

Feb 19, 2008

Appl. No.:

12/867980

Inventors:

Patrick Shawn Beaty - Dallastown PA, US

International Classification:

G06F 19/00
G01J 1/58

US Classification:

702 19, 2504591

Abstract:

Systems, methods and apparatus for determining an amount of blood in a blood culture are provided where an initial biological state and then periodic measurements of the biological state of the culture are taken. For each respective measurement, a normalization relative value between the respective measurement and the initial measurement is made thereby forming normalization relative values. For each interval of time points represented by the normalization relative values, a first derivative of the normalization relative values in the interval is made thereby forming a plurality of rate transformation values. For each set of rate transformation values in the plurality of rate transformation values, an average relative transformation value is computed, thereby forming average relative transformation values. A lookup table that matches a measure of central tendency of the average relative transformation values to a blood amount is used to determine the amount of blood in the culture.

US Patent:

20110029252, Feb 3, 2011

Filed:

Feb 19, 2008

Appl. No.:

12/918019

Inventors:

Patrick Shawn Beaty - Dallastown PA, US

International Classification:

G06F 19/00
G01N 33/48

US Classification:

702 19

Abstract:

Systems, methods, and apparatus for determining whether a culture in a vessel contains a plurality of microorganisms are provided. A normalization relative value is calculated for each respective measurement of a biological state of the culture between (i) the respective measurement and (ii) an initial biological state. For each fixed interval of time points, a derivative of the normalization relative values in the interval of time points is calculated, thereby forming a plurality of rate transformation values. For each set of rate transformation values in the plurality of rate transformation values, a measure of central tendency of the values in the set is computed, thereby forming a plurality of average relative transformation values. A determination whether the culture contains the microorganisms is made based on whether any calculated average relative transformation value exceeds a first threshold or whether an extent of growth exhibited by the culture exceeds a second threshold.

US Patent:

20110208432, Aug 25, 2011

Filed:

Feb 19, 2008

Appl. No.:

12/918011

Inventors:

Patrick Shawn Beaty - Dallastown PA, US

International Classification:

G06F 19/00
G01N 33/48

US Classification:

702 19

Abstract:

Systems, methods and apparatus for identifying a microorganism type in a culture are provided. A normalization relative value is calculated for each respective measurement of a biological state of the culture between (i) the respective measurement and (ii) an initial biological state. For each fixed interval of time points, a first derivative of the normalization relative values in the interval of time points is calculated, thereby forming a plurality of rate transformation values. For each respective set of rate transformation values in the plurality of rate transformation values, a measure of central tendency of the rate transformation values in the set is computed, thereby forming a plurality of average relative transformation values. A maximum metabolic rate and an extent of growth, determined from the normalization relative values and the average relative transformation values, are compared against a lookup table that matches these values to a microorganism type.

US Patent:

20200340029, Oct 29, 2020

Filed:

Jul 13, 2020

Appl. No.:

16/926926

Inventors:

- Franklin Lakes NJ, US
Brent Pohl - Timonium MD, US
Gary F. Hershner - Red Lion PA, US
Dwight Livingston - Fallston MD, US
Eric Ursprung - Camp Hill PA, US
Gerard Lotz - Fallston MD, US
Kevin Bailey - Monkton MD, US
Ammon David Lentz - York PA, US
Michael A. Brasch - Gaithersburg MD, US
Ming-hsiung Yeh - New Freedom PA, US
Patrick Shawn Beaty - Dallastown PA, US
Charles C. Yu - Lutherville MD, US
Timothy M. Wiles - Manchester MD, US
Liping Feng - Baltimore MD, US
Ben Turng - Tucson AZ, US
Xiaofei Chang - Timonium MD, US
Patrick R. Murray - Gibson Island MD, US

International Classification:

C12Q 1/02
A61J 1/05
C12M 1/24
A61J 1/14
A61J 1/20
B01L 3/00
C12M 1/00

Abstract:

An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel , a vessel insert , and a cap element . The vessel has a body portion for receiving a biological sample. The vessel insert receives at least one reagent therein. Preferably, the vessel insert is received in a portion of the vessel . The cap element is attached to the vessel to secure the vessel insert in the vessel . During use, the vessel insert is adapted to release its contents when the biological sample is introduced into the body portion of the vessel upon application of an intermixing force to the vessel insert . A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.

US Patent:

20200087702, Mar 19, 2020

Filed:

Nov 7, 2019

Appl. No.:

16/677092

Inventors:

- Franklin Lakes NJ, US
Vanda White - Baltimore MD, US
William B. Brasso - Columbia MD, US
Dyan Luper - Cockeysville MD, US
James Y. Zhou - Columbia MD, US
Julie L. Rosales - Randallstown MD, US
Jeffery H. Bruton - Randallstown MD, US
John D. Mantlo - Sykesville MD, US
Adrien P. Malick - Granite MD, US
Donald R. Callihan - Cockeysville MD, US
Ben Turng - Tucson AZ, US
Liping Feng - Baltimore MD, US
Curtis M. Gosnell - Fallston MD, US
Patrick Shawn Beaty - Dallastown PA, US
John P. Douglass - York PA, US

Assignee:

BECTON DICKINSON AND COMPANY - Franklin Lakes NJ

International Classification:

C12Q 1/14
C12Q 1/24
C12N 1/02
C12N 1/20

Abstract:

Various embodiments disclosed herein provide for reagents and methods for rapidly isolating viable microbial cells, including , from positive blood culture samples. The resulting microbial pellet can be used for both identification and growth-based methods such as antimicrobial susceptibility testing. The buffers described herein may contain a base solution, non-ionic detergents, thiols, and optionally, ammonium chloride. The disclosed methods provide a process for rapidly isolating and concentrating viable microorganism(s) from PBC samples using only one sample preparation tube and centrifugation while removing cellular debris from the mammalian blood cells that may interfere with identification methods.

US Patent:

20190276869, Sep 12, 2019

Filed:

May 29, 2019

Appl. No.:

16/425213

Inventors:

- Franklin Lakes NJ, US
Patrick Shawn Beaty - Dallastown PA, US

Assignee:

BECTON DICKINSON AND COMPANY - Franklin Lakes NJ

International Classification:

C12Q 1/04

Abstract:

Systems, methods, and apparatus for determining whether a culture in a vessel contains a plurality of microorganisms are provided. A normalization relative value is calculated for each respective measurement of a biological state of the culture between (i) the respective measurement and (ii) an initial biological state. For each fixed interval of time points, a derivative of the normalization relative values in the interval of time points is calculated, thereby forming a plurality of rate transformation values. For each set of rate transformation values in the plurality of rate transformation values, a measure of central tendency of the values in the set is computed, thereby forming a plurality of average relative transformation values. A determination whether the culture contains the microorganisms is made based on whether any calculated average relative transformation value exceeds a first threshold or whether an extent of growth exhibited by the culture exceeds a second threshold.

US Patent:

20160265022, Sep 15, 2016

Filed:

Oct 24, 2014

Appl. No.:

15/031958

Inventors:

- Franklin Lakes NJ, US
Brent Pohl - Timonium MD, US
Gary F. Hershner - Red Lion PA, US
Dwight Livingston - Fallston MD, US
Eric Ursprung - Camp Hill PA, US
Gerard Lotz - Fallston MD, US
Kevin Bailey - Cockeysville MD, US
Ammon David Lentz - York PA, US
Michael A. Brasch - Gaithersburg MD, US
Ming-hsiung Yeh - New Freedom PA, US
Patrick Shawn Beaty - Dallastown PA, US
Charles C. Yu - Lutherville MD, US
Timothy M. Wiles - Manchester MD, US
Liping Feng - Baltimore MD, US
Ben Turng - Tucson AZ, US
Xiaofei Chang - Timonium MD, US
Patrick R. Murray - Gibson Island MD, US

Assignee:

BECTON, DICKINSON AND COMPANY - Franklin Lakes NJ

International Classification:

C12Q 1/02
C12M 1/00
A61J 1/20
C12M 1/24
A61J 1/05
A61J 1/14

Abstract:

An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel , a vessel insert , and a cap element . The vessel has a body portion for receiving a biological sample. The vessel insert receives at least one reagent therein. Preferably, the vessel insert is received in a portion of the vessel . The cap element is attached to the vessel to secure the vessel insert in the vessel . During use, the vessel insert is adapted to release its contents when the biological sample is introduced into the body portion of the vessel upon application of an intermixing force to the vessel insert . A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.