Patrick E Dailey

US Patent:

20100040727, Feb 18, 2010

Filed:

Aug 18, 2008

Appl. No.:

12/193079

Inventors:

Garry L. Myers - Kingsport IN, US
Madhusudan Hariharan - Munster IN, US
Pradeep Sanghvi - Schererville IN, US
Alex Szopinski - Chesterton IN, US
Patrick Dailey - Merrillville IN, US

Assignee:

MONOSOL RX, LLC - Portage IN

International Classification:

A61K 9/70
A23P 1/10

US Classification:

426 2, 426517, 426658

Abstract:

The present invention relates to a method of making a film composition with an improved uniformity of active composition. The invention includes a method including the steps of forming a flowable film composition comprising an edible water-soluble polymer, a polar solvent and a particulate active suspended therein, where the ratio of solids to liquids is at least about 95 to about 5 and where the composition comprises a mixture having compositional uniformity per unit volume; directing the flowable film composition to a transfer trough, the transfer trough including a first rotating roller and a movable transfer substrate upon which to form the film; and maintaining uniformity of the flowable film composition during the residence time in the trough by maintaining the rate of composition entering the transfer trough and the level of the flowable film composition in the transfer trough at a substantially constant level. Methods of administering the active are also contemplated.