Patrick F Dowd

US Patent:

7547768, Jun 16, 2009

Filed:

Nov 20, 2007

Appl. No.:

11/943454

Inventors:

Patrick Dowd - San Francisco CA, US
Gretchen Frantz - San Francisco CA, US
Paul Polakis - Burlingame CA, US
Victoria Smith - Burlingame CA, US
Susan D. Spencer - Tiburon CA, US
Thomas D. Wu - San Francisco CA, US
Zemin Zhang - Foster City CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07K 16/00
C12P 21/08
C12P 21/04
A61K 39/395
C07H 21/04

US Classification:

5303881, 4241331, 4241411, 4241551, 4241811, 435 696, 435 7021, 5303873, 5303888, 5303917

Abstract:

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

US Patent:

8398982, Mar 19, 2013

Filed:

Apr 13, 2009

Appl. No.:

12/422424

Inventors:

Patrick Dowd - San Francisco CA, US
Gretchen Frantz - San Francisco CA, US
Paul Polakis - Burlingame CA, US
Victoria Smith - Burlingame CA, US
Susan D. Spencer - Tiburon CA, US
Thomas D. Wu - San Francisco CA, US
Zemin Zhang - Foster City CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 39/00

US Classification:

4241781, 4241821, 4241831

Abstract:

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. TAT113 polypeptides comprising the amino acid sequence of SEQ ID NO: 2 are disclosed. Antibodies that bind TAT113 polypeptides, including monoclonal, chimeric, humanized, single chain, and other antibodies, and fragments thereof, are disclosed. Methods of identifying antibodies that bind epitopes bound by such antibodies, including the antibodies produced by hybridoma cell lines disclosed in the application, are provided, wherein the ability of one antibody to block the binding of another antibody to a TAT113 polypeptide indicates that one antibody binds to an epitope bound by the other antibody. Methods of diagnosing the presence of a tumor in a mammal using such antibodies are disclosed, wherein detection of the formation of a complex between an antibody and a protein in a test sample is indicative of the presence of a tumor in said mammal. Methods of inhibiting the growth of a cancer cell that expresses a protein comprising the amino acid sequence of SEQ ID NO: 2, are disclosed, where the binding of the antibody to the protein inhibits the growth of the cell.

US Patent:

20050170368, Aug 4, 2005

Filed:

Jul 2, 2004

Appl. No.:

10/884070

Inventors:

Avi Ashkenazi - San Mateo CA, US
Belinda Caims - Burlingame CA, US
Patrick Dowd - San Francisco CA, US
Gretchen Frantz - San Francisco CA, US
Dorothy French - San Carlos CA, US
Lino Gonzalez - Hollister CA, US
Paul Polakis - Burlingame CA, US
Victoria Smith - Burlingame CA, US
Beni Wolf - Redwood City CA, US
Thomas Wu - San Francisco CA, US
Zemin Zhang - Foster City CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C12Q001/68
G01N033/574
C07K014/82
C07H021/04

US Classification:

435006000, 435007230, 435069100, 435320100, 435325000, 530350000, 536023500

Abstract:

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

US Patent:

20050272120, Dec 8, 2005

Filed:

Apr 8, 2005

Appl. No.:

11/102501

Inventors:

Patrick Dowd - San Francisco CA, US
Gretchen Frantz - San Francisco CA, US
Paul Polakis - Burlingame CA, US
Victoria Smith - Burlingame CA, US
Susan Spencer - Tiburon CA, US
Thomas Wu - San Francisco CA, US
Zemin Zhang - Foster City CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07H021/04
C12P021/06
A61K039/395
C12N005/06
C12N001/18

US Classification:

435069100, 435358000, 435252330, 435254200, 536023200

Abstract:

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

US Patent:

20070048825, Mar 1, 2007

Filed:

Oct 4, 2006

Appl. No.:

11/538517

Inventors:

Patrick Dowd - San Francisco CA, US
Gretchen Frantz - San Francisco CA, US
Paul Polakis - Burlingame CA, US
Victoria Smith - Burlingame CA, US
Susan Spencer - Tiburon CA, US
Thomas Wu - San Francisco CA, US
Zemin Zhang - Foster City CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07K 14/82
C07H 21/04
C12P 21/06
C12N 1/21
C12N 1/18
C12N 5/06

US Classification:

435069100, 530350000, 536023500, 435320100, 435358000, 435252330, 435254200

Abstract:

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

US Patent:

20070212735, Sep 13, 2007

Filed:

Sep 25, 2006

Appl. No.:

11/534850

Inventors:

Avi Ashkenazi - San Mateo CA, US
Belinda Caims - Burlingame CA, US
Patrick Dowd - San Francisco CA, US
Gretchen Frantz - San Francisco CA, US
Dorothy French - San Carlos CA, US
Lino Gonzalez - Hollister CA, US
Paul Polakis - Burlingame CA, US
Victoria Smith - Burlingame CA, US
Beni Wolf - Redwood City CA, US
Thomas Wu - San Francisco CA, US
Zemin Zhang - Foster City CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

G01N 33/574
C07K 16/30
C07K 14/82

US Classification:

435007230, 435069700, 530350000, 530388800

Abstract:

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.