Patrick J Hrdlicka from 866 Conestoga Dr, Moscow, ID 83843, age 48

Nucleobase-Functionalized Conformationally Restricted Nucleotides And Oligonucleotides For Targeting Of Nucleic Acids
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US Patent:

20120295862, Nov 22, 2012
Filed:

Mar 9, 2012
Appl. No.:

13/416906
Inventors:

Patrick J. Hrdlicka - Moscow ID, US
Pawan Kumar - Kurukshetra, IN
Michael E. Østergaard - Moscow ID, US
International Classification:

A61K 31/7072
C07H 19/06
C07H 19/10
C07H 19/16
C12Q 1/68
A61K 31/708
US Classification:

514 46, 435 611, 514 47, 514 50, 514 51, 536 268, 536 2721, 536 2854
Abstract:

Embodiments are disclosed herein that involve C5-functionalized nucleic acids, which can be used for detecting a target in a nucleic acid. Particular embodiments disclose methods for making these compounds, wherein the compounds can be formed by coupling of an intermediate with a linker. Certain embodiments disclose the use of these compounds for detecting single nucleotide polymorphisms, and for increasing the thermal affinity of nucleic acid complements as compared to unmodified nucleic acid complements. In addition, the disclosed compounds can decrease enzymatic degradation of nucleic acids.

Nucleobase-Functionalized Conformationally Restricted Nucleotides And Oligonucleotides For Targeting Nucleic Acids
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US Patent:

20130337581, Dec 19, 2013
Filed:

Jun 19, 2013
Appl. No.:

13/922068
Inventors:

Patrick Jerzy Hrdlicka - Moscow ID, US
Pawan Kumar - Kurukshetra, IN
Michael E. Østergaard - Moscow ID, US
Assignee:

University of Idaho - Moscow ID
International Classification:

C07H 19/16
C12Q 1/68
C07H 19/10
C07H 19/06
US Classification:

436501, 536 2855, 536 2854, 536 268, 536 276
Abstract:

Embodiments are disclosed herein that involve C5-functionalized nucleic acids, which can be used for detecting a target in a nucleic acid. Particular embodiments disclose methods for making these compounds, wherein the compounds can be formed by coupling of an intermediate with a linker. Certain embodiments disclose the use of these compounds for detecting single nucleotide polymorphisms, and for increasing the thermal affinity of nucleic acid complements as compared to unmodified nucleic acid complements. In addition, the disclosed compounds can decrease enzymatic degradation of nucleic acids.

Embodiments Of A Probe And Method For Targeting Nucleic Acids
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US Patent:

20140220573, Aug 7, 2014
Filed:

Jul 19, 2012
Appl. No.:

14/233375
Inventors:

Patrick Jerzy Hrdlicka - Moscow ID, US
Assignee:

University Of Idaho - Moscow ID
International Classification:

C12Q 1/68
US Classification:

435 611, 536 243, 436 94
Abstract:

Disclosed embodiments concern a probe comprising one or more pairs of monomers capable of targeting a nucleic acid target. The pair of monomers may be arranged in a manner that promotes thermoinstability of the probe complex, thus producing a probe capable of locating and/or detecting a target. The probe also may comprise one or more natural or non-natural nucleotides capable of Watson-Crick base pairing with an isosequential nucleic acid target. Particular disclosed embodiments concern a method of using the disclosed probe to target nucleic acids. In particular disclosed embodiments, the probe may be incubated with a target nucleic acid and then be detected.

Patrick J Hrdlicka