Patrick Rory Martin

US Patent:

6514746, Feb 4, 2003

Filed:

May 20, 1998

Appl. No.:

09/082077

Inventors:

Bret Benton - San Bruno CA
Francois Malouin - Los Gatos CA
Patrick K. Martin - Sunnyvale CA
Molly B. Schmid - Los Altos CA
Dongxu Sun - Cupertino CA

Assignee:

Essential Therapeutics, Inc. - Mountain View CA

International Classification:

C12N 120

US Classification:

4352523, 536 231, 536 243, 536 2432, 536 2433, 4353201

Abstract:

This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial genes which encode the components of a two-component regulatory pair. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.

US Patent:

6630303, Oct 7, 2003

Filed:

Mar 17, 2000

Appl. No.:

09/528709

Inventors:

Bret Benton - Burlingame CA
Ving J. Lee - Los Altos CA
Francois Malouin - Los Gatos CA
Patrick K. Martin - Sunnyvale CA
Molly B. Schmid - Menlo Park CA
Dongxu Sun - Cupertino CA

Assignee:

Essential Therapeutics, Inc. - Mountain View CA

International Classification:

C12Q 168

US Classification:

435 6, 435 691, 436 63, 436501, 514 2, 514 44

Abstract:

This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.

US Patent:

6638718, Oct 28, 2003

Filed:

Mar 17, 2000

Appl. No.:

09/527745

Inventors:

Bret Benton - Burlingame CA
Ving J. Lee - Los Altos CA
Francois Malouin - Los Gatos CA
Patrick K. Martin - Sunnyvale CA
Molly B. Schmid - Menlo Park CA
Dongxu Sun - Cupertino CA

Assignee:

Essential Therapeutics, Inc. - Mountain View CA

International Classification:

C12Q 168

US Classification:

435 6, 435 691, 436 63, 436501, 514 2, 514 44

Abstract:

This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.

US Patent:

8349600, Jan 8, 2013

Filed:

Jan 6, 2006

Appl. No.:

11/327195

Inventors:

Patrick K. Martin - Redwood City CA, US
David A. Simpson - Redwood City CA, US

Assignee:

Applied Biosystems, LLC - Carlsbad CA

International Classification:

C12N 9/12

US Classification:

435194, 435183, 530350

Abstract:

Polypeptides having nucleic acid binding activity are provided. Methods of stabilizing a nucleic acid duplex are provided. Methods of promoting the annealing of complementary nucleic acid strands are provided. Methods of increasing the processivity of a DNA polymerase are provided. Methods of enhancing the activity of a nucleic acid modification enzyme are provided. Fusion proteins are provided. Methods of using fusion proteins are provided. Kits are provided.

US Patent:

20060228726, Oct 12, 2006

Filed:

Jan 6, 2006

Appl. No.:

11/327845

Inventors:

Patrick Martin - Redwood City CA, US
David Simpson - Redwood City CA, US
Christine Hardy - Hayward CA, US

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435006000, 435091200

Abstract:

Polypeptides having nucleic acid binding activity are provided. Methods of using polypeptides having nucleic acid binding activity are provided. Fusion proteins and methods of using fusion proteins are provided. Fusion proteins comprising a polymerase and a nucleic acid binding polypeptide are provided. Fusion proteins comprising a reverse transcriptase and a nucleic acid binding polypeptide are provided. Methods are provided for amplifying a nucleic acid sequence using a fusion protein comprising a nucleic acid binding polypeptide and a polymerase. Methods are provided for amplifying a nucleic acid sequence using a fusion protein comprising a nucleic acid binding polypeptide and a reverse transcriptase.

US Patent:

20070059709, Mar 15, 2007

Filed:

Jul 21, 2003

Appl. No.:

10/624725

Inventors:

Bret Benton - Burlingame CA, US
Ving Lee - Los Altos CA, US
Francois Malouin - Los Gatos CA, US
Patrick Martin - Sunnyvale CA, US
Molly Schmid - Menlo Park CA, US
Dongxu Sun - Cupertino CA, US

International Classification:

C12Q 1/68
G01N 33/554
A61K 31/4196
A61K 31/4439

US Classification:

435006000, 435007320, 514341000, 514383000

Abstract:

This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.

US Patent:

20070190538, Aug 16, 2007

Filed:

Jul 31, 2006

Appl. No.:

11/496596

Inventors:

Patrick Martin - Redwood City CA, US
David Simpson - Redwood City CA, US

Assignee:

Applera Corporation - Foster City CA

International Classification:

C12Q 1/68
C07H 21/04
C12P 21/06
C12N 9/22
C12N 15/74
C12N 1/21

US Classification:

435006000, 435069100, 435199000, 435252300, 435471000, 536023200

Abstract:

Disclosed herein are chimeric polymerases and methods of making and using same.

US Patent:

20080118917, May 22, 2008

Filed:

Nov 21, 2006

Appl. No.:

11/562345

Inventors:

Christine D. Hardy - Hayward CA, US
Patrick K. Martin - Redwood City CA, US

Assignee:

Applera Corporation - Foster City CA

International Classification:

C12Q 1/68
C07H 21/04

US Classification:

435 6, 536 231

Abstract:

In some embodiments, the present teachings provide a method for detecting a nucleotide of interest comprising; forming an amplification reaction mixture comprising a mismatched primer, a target polynucleotide, a strand-displacing polymerase lacking 3′ to 5′ exonuclease activity, a recombinase, and a single-stranded DNA binding protein; hybridizing a mismatched primer to the target polynucleotide to form a primer-target complex; and, detecting the nucleotide of interest by the absence of a primer extension product. In some embodiments, control reactions are performed in which a control polynucleotide is exponentially amplified. Additional methods, as well as reaction mixtures and kits, are also provided.