Patrick F Mchugh

US Patent:

51209896, Jun 9, 1992

Filed:

Feb 4, 1991

Appl. No.:

7/652706

Inventors:

Douglas C. Johnson - Ocean NJ
Arnold Bard - Elberon NJ
Patrick F. McHugh - West Long Branch NJ

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

H03K 500

US Classification:

307269

Abstract:

Drive signals generated at a single location are utilized to derive localized clock signals at several locations. The drive signals are phase shifted and have identical frequencies, while the clock signals derived therefrom are some frequency multiple thereof.

US Patent:

20230073288, Mar 9, 2023

Filed:

Feb 24, 2021

Appl. No.:

17/800271

Inventors:

Jennifer C. P. WANG - West Point PA, US
Kelsey A. RICHARDS - Philadelphia PA, US
Jayesh DESAI - Kenilworth NJ, US
Bhumit A. PATEL - Kenilworth NJ, US
Michael A. WINTERS - West Point PA, US
Patrick M. MCHUGH - West Point PA, US
Philip R. KUHL - West Point PA, US
John P. HIGGINS - West Point PA, US
Michael I. LARKIN - Santa Barbara CA, US
Michelle H. CHEN - Goleta CA, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme LLC - Rahway NJ

International Classification:

A61K 39/09
C08B 37/00

Abstract:

The present invention relates to Polysaccharide Size-Reduction Monitoring Methods useful for the non-invasive, and accurate monitoring of the progress of a polysaccharide size-reduction process.

US Patent:

20210330777, Oct 28, 2021

Filed:

Jul 7, 2021

Appl. No.:

17/369177

Inventors:

- Rahway NJ, US
John E. MacNair - Lansdale PA, US
William J. Smith - Harleysville PA, US
Michael A. Winters - Doylestown PA, US
Joseph G. Joyce - Lansdale PA, US
Chitrananda Abeygunawardana - Ambler PA, US
Luwy Musey - Blue Bell PA, US
Hari Pujar - Berwyn PA, US
Julie M. Skinner - Phoenixville PA, US
Patrick McHugh - Pipersville PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 39/09
A61K 47/64
A61P 31/04
A61K 39/116

Abstract:

The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.

US Patent:

20210252125, Aug 19, 2021

Filed:

Apr 25, 2019

Appl. No.:

17/049245

Inventors:

Patrick Leonard AHL - West Point PA, US
Akhilesh BHAMBHANI - West Point PA, US
Christopher Jon FARRELL - West Point PA, US
Patrick MCHUGH - West Point PA, US
Morrisa C. JONES - West Point PA, US
Daniel D. ROTH - West Point PA, US
Jessica R. SINACOLA - West Point PA, US
Justin STANBRO - West Point PA, US
Matthew P. WATSON - West Point PA, US
Emily WEN - West Point PA, US
Michael A. WINTERS - West Point PA, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 39/09
A61K 47/62
A61K 47/61

Abstract:

A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized, the separately lyophilized polysaccharides and carrier protein are separately reconstituted in an organic solvent, and the reconstituted polysaccharide and carrier protein are then combined together by Tee-mixing and conjugated together to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.

US Patent:

20210038723, Feb 11, 2021

Filed:

Sep 4, 2018

Appl. No.:

16/645068

Inventors:

- Rahway NJ, US
Chitrananda Abeygunawardana - Ambler PA, US
Luwy Kavuka Musey - Blue Bell PA, US
Michael J. Kosinski - Souderton PA, US
Yadong Adam Cui - Norristown PA, US
Patrick McHugh - Pipersville PA, US
Janelle Konietzko - Lansdale PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 47/26
A61K 47/42
A61K 47/36
A61K 47/54

Abstract:

The present invention provides capsular polysaccharides from serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional serotypes.

US Patent:

20200054733, Feb 20, 2020

Filed:

Feb 20, 2018

Appl. No.:

16/487550

Inventors:

- Rahway NJ, US
John E. MacNair - Lansdale PA, US
William J. Smith - Harleysville PA, US
Michael A. Winters - Doylestown PA, US
Joseph G. Joyce - Lansdale PA, US
Chitrananda Abeygunawardana - Ambler PA, US
Luwy Musey - Blue Bell PA, US
Hari Pujar - Berwyn PA, US
Julie M. Skinner - Phoenixville PA, US
Emily Wen - Harleysville PA, US
Patrick McHugh - Pipersville PA, US
John Michael Williams - Hillsborough NJ, US
Catherine Lancaster - Southhampton PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 39/09
A61K 39/116
A61P 31/04
A61K 47/64

Abstract:

The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.

US Patent:

20140193876, Jul 10, 2014

Filed:

Jun 8, 2012

Appl. No.:

14/125695

Inventors:

Aaron R. Goerke - Wayne PA, US
Thomas Svab - Plains PA, US
Patrick McHugh - Perkasie PA, US
Kristin Valente - Plymouth Meeting PA, US

International Classification:

C12N 9/10

US Classification:

435193

Abstract:

The present invention relates to the use of hydroxyapatite chromatography and multimodal chromatography, for punfication of diphtheria toxin, or a mutant form thereof, from a mixture, for example, a host cell fermentation mixture containing impurities such as host cell proteins and DNA. This invention further relates to the integration of such a method into a multi-step procedure with other fractionation methods for purification of diphtheria toxin suitable for in vitro and in vivo applications.