Patrick J Mchugh

US Patent:

20230073288, Mar 9, 2023

Filed:

Feb 24, 2021

Appl. No.:

17/800271

Inventors:

Jennifer C. P. WANG - West Point PA, US
Kelsey A. RICHARDS - Philadelphia PA, US
Jayesh DESAI - Kenilworth NJ, US
Bhumit A. PATEL - Kenilworth NJ, US
Michael A. WINTERS - West Point PA, US
Patrick M. MCHUGH - West Point PA, US
Philip R. KUHL - West Point PA, US
John P. HIGGINS - West Point PA, US
Michael I. LARKIN - Santa Barbara CA, US
Michelle H. CHEN - Goleta CA, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme LLC - Rahway NJ

International Classification:

A61K 39/09
C08B 37/00

Abstract:

The present invention relates to Polysaccharide Size-Reduction Monitoring Methods useful for the non-invasive, and accurate monitoring of the progress of a polysaccharide size-reduction process.

US Patent:

20210330777, Oct 28, 2021

Filed:

Jul 7, 2021

Appl. No.:

17/369177

Inventors:

- Rahway NJ, US
John E. MacNair - Lansdale PA, US
William J. Smith - Harleysville PA, US
Michael A. Winters - Doylestown PA, US
Joseph G. Joyce - Lansdale PA, US
Chitrananda Abeygunawardana - Ambler PA, US
Luwy Musey - Blue Bell PA, US
Hari Pujar - Berwyn PA, US
Julie M. Skinner - Phoenixville PA, US
Patrick McHugh - Pipersville PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 39/09
A61K 47/64
A61P 31/04
A61K 39/116

Abstract:

The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.

US Patent:

20210252125, Aug 19, 2021

Filed:

Apr 25, 2019

Appl. No.:

17/049245

Inventors:

Patrick Leonard AHL - West Point PA, US
Akhilesh BHAMBHANI - West Point PA, US
Christopher Jon FARRELL - West Point PA, US
Patrick MCHUGH - West Point PA, US
Morrisa C. JONES - West Point PA, US
Daniel D. ROTH - West Point PA, US
Jessica R. SINACOLA - West Point PA, US
Justin STANBRO - West Point PA, US
Matthew P. WATSON - West Point PA, US
Emily WEN - West Point PA, US
Michael A. WINTERS - West Point PA, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 39/09
A61K 47/62
A61K 47/61

Abstract:

A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized, the separately lyophilized polysaccharides and carrier protein are separately reconstituted in an organic solvent, and the reconstituted polysaccharide and carrier protein are then combined together by Tee-mixing and conjugated together to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.

US Patent:

20200054733, Feb 20, 2020

Filed:

Feb 20, 2018

Appl. No.:

16/487550

Inventors:

- Rahway NJ, US
John E. MacNair - Lansdale PA, US
William J. Smith - Harleysville PA, US
Michael A. Winters - Doylestown PA, US
Joseph G. Joyce - Lansdale PA, US
Chitrananda Abeygunawardana - Ambler PA, US
Luwy Musey - Blue Bell PA, US
Hari Pujar - Berwyn PA, US
Julie M. Skinner - Phoenixville PA, US
Emily Wen - Harleysville PA, US
Patrick McHugh - Pipersville PA, US
John Michael Williams - Hillsborough NJ, US
Catherine Lancaster - Southhampton PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 39/09
A61K 39/116
A61P 31/04
A61K 47/64

Abstract:

The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.

US Patent:

20140193876, Jul 10, 2014

Filed:

Jun 8, 2012

Appl. No.:

14/125695

Inventors:

Aaron R. Goerke - Wayne PA, US
Thomas Svab - Plains PA, US
Patrick McHugh - Perkasie PA, US
Kristin Valente - Plymouth Meeting PA, US

International Classification:

C12N 9/10

US Classification:

435193

Abstract:

The present invention relates to the use of hydroxyapatite chromatography and multimodal chromatography, for punfication of diphtheria toxin, or a mutant form thereof, from a mixture, for example, a host cell fermentation mixture containing impurities such as host cell proteins and DNA. This invention further relates to the integration of such a method into a multi-step procedure with other fractionation methods for purification of diphtheria toxin suitable for in vitro and in vivo applications.