Patrick L Mchugh

US Patent:

20220233674, Jul 28, 2022

Filed:

Jun 1, 2020

Appl. No.:

17/614865

Inventors:

- Rahway NJ, US
Patrick McHugh - Pipersville PA, US
Katherine M. Phillips - Audubon PA, US
Adriana N. Santiago-Miranda - Conshohocken PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 39/09
A61K 39/385
A61P 31/04

Abstract:

The present invention provides a process improvement related to the conjugation of capsular polysaccharides from () serotype 35B to a carrier protein. The serotype 35B polysaccharide-protein conjugate, prepared by the disclosed process, is, among other things, more immunogenic than similar conjugates made by prior art methods. serotype 35B polysaccharide-protein conjugates prepared using the processes of the invention can be included in multivalent pneumococcal conjugate vaccine compositions.

US Patent:

20230077640, Mar 16, 2023

Filed:

Oct 25, 2022

Appl. No.:

18/049507

Inventors:

- Rahway NJ, US
Akhilesh Bhambhani - Doylestown PA, US
Christopher Jon Farrell - Wayne PA, US
Patrick McHugh - Pipersville PA, US
Morrisa C. Jones - Upper Darby PA, US
Daniel D. Roth - Coopersburg PA, US
Jessica R. Sinacola - Collegeville PA, US
Justin Stanbro - Sellersville PA, US
Matthew P. Watson - Ottsville PA, US
Emily Wen - Harleysville PA, US
Michael A. Winters - Doylestown PA, US

Assignee:

Merck Sharp & Dohme LLC - Rahway NJ

International Classification:

A61K 39/09
A61K 47/61
A61K 47/62

Abstract:

A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized, the separately lyophilized polysaccharides and carrier protein are separately reconstituted in an organic solvent, and the reconstituted polysaccharide and carrier protein are then combined together by Tee-mixing and conjugated together to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.

US Patent:

20230073288, Mar 9, 2023

Filed:

Feb 24, 2021

Appl. No.:

17/800271

Inventors:

Jennifer C. P. WANG - West Point PA, US
Kelsey A. RICHARDS - Philadelphia PA, US
Jayesh DESAI - Kenilworth NJ, US
Bhumit A. PATEL - Kenilworth NJ, US
Michael A. WINTERS - West Point PA, US
Patrick M. MCHUGH - West Point PA, US
Philip R. KUHL - West Point PA, US
John P. HIGGINS - West Point PA, US
Michael I. LARKIN - Santa Barbara CA, US
Michelle H. CHEN - Goleta CA, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme LLC - Rahway NJ

International Classification:

A61K 39/09
C08B 37/00

Abstract:

The present invention relates to Polysaccharide Size-Reduction Monitoring Methods useful for the non-invasive, and accurate monitoring of the progress of a polysaccharide size-reduction process.

US Patent:

20210379174, Dec 9, 2021

Filed:

Jul 13, 2021

Appl. No.:

17/374424

Inventors:

- Rahway NJ, US
Patrick McHugh - Pipersville PA, US
Michael A. Winters - Doylestown PA, US
Julie M. Skinner - Phoenixville PA, US
Jian He - Blue Bell PA, US
Luwy Musey - Blue Bell PA, US
Chitrananda Abeygunawardana - Ambler PA, US
Yadong Adam Cui - Norristown PA, US
Michael J. Kosinski - Souderton PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 39/09
A61K 39/385
A61K 39/145
A61P 31/04
A61K 39/116
A61K 47/02
A61K 47/10
A61K 47/22

Abstract:

The invention is related to multivalent immunogenic compositions comprising more than one polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an serotype conjugated to a carrier protein, wherein the serotypes of are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against infection and diseases caused by . The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.

US Patent:

20210330777, Oct 28, 2021

Filed:

Jul 7, 2021

Appl. No.:

17/369177

Inventors:

- Rahway NJ, US
John E. MacNair - Lansdale PA, US
William J. Smith - Harleysville PA, US
Michael A. Winters - Doylestown PA, US
Joseph G. Joyce - Lansdale PA, US
Chitrananda Abeygunawardana - Ambler PA, US
Luwy Musey - Blue Bell PA, US
Hari Pujar - Berwyn PA, US
Julie M. Skinner - Phoenixville PA, US
Patrick McHugh - Pipersville PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 39/09
A61K 47/64
A61P 31/04
A61K 39/116

Abstract:

The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.

US Patent:

20210252125, Aug 19, 2021

Filed:

Apr 25, 2019

Appl. No.:

17/049245

Inventors:

Patrick Leonard AHL - West Point PA, US
Akhilesh BHAMBHANI - West Point PA, US
Christopher Jon FARRELL - West Point PA, US
Patrick MCHUGH - West Point PA, US
Morrisa C. JONES - West Point PA, US
Daniel D. ROTH - West Point PA, US
Jessica R. SINACOLA - West Point PA, US
Justin STANBRO - West Point PA, US
Matthew P. WATSON - West Point PA, US
Emily WEN - West Point PA, US
Michael A. WINTERS - West Point PA, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 39/09
A61K 47/62
A61K 47/61

Abstract:

A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized, the separately lyophilized polysaccharides and carrier protein are separately reconstituted in an organic solvent, and the reconstituted polysaccharide and carrier protein are then combined together by Tee-mixing and conjugated together to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.

US Patent:

20210252126, Aug 19, 2021

Filed:

Apr 25, 2019

Appl. No.:

17/049266

Inventors:

- Rahway NJ, US
Akhilesh Bhambhani - Doylestown PA, US
Christopher Jon Farrell - Wayne PA, US
Patrick McHugh - Pipersville PA, US
Morrisa C. Jones - Upper Darby PA, US
Daniel D. Roth - Coopersburg PA, US
Jessica R. Sinacola - Collegeville PA, US
Justin Stanbro - Sellersville PA, US
Matthew P. Watson - Ottsville PA, US
Emily Wen - Harleysville PA, US
Michael A. Winters - Doylestown PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 39/09
A61K 9/19
A61K 39/39
A61K 47/20

Abstract:

A method is described for reconstituting lyophilized mutant diphtheria toxin in dimethyl sulfoxide for use in producing pneumococcal capsular polysaccharide mutant diphtheria toxin conjugates.

US Patent:

20210038723, Feb 11, 2021

Filed:

Sep 4, 2018

Appl. No.:

16/645068

Inventors:

- Rahway NJ, US
Chitrananda Abeygunawardana - Ambler PA, US
Luwy Kavuka Musey - Blue Bell PA, US
Michael J. Kosinski - Souderton PA, US
Yadong Adam Cui - Norristown PA, US
Patrick McHugh - Pipersville PA, US
Janelle Konietzko - Lansdale PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 47/26
A61K 47/42
A61K 47/36
A61K 47/54

Abstract:

The present invention provides capsular polysaccharides from serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional serotypes.