Patrick Joseph Powers

US Patent:

20060008415, Jan 12, 2006

Filed:

Jun 24, 2005

Appl. No.:

11/166906

Inventors:

Elisabet Kaisheva - Belmont CA, US
Supriya Gupta - Sunnyvale CA, US
Weichang Zhou - Livermore CA, US
Robert Weinkam - San Carlos CA, US
Patrick Powers - Palo Alto CA, US
Naichi Liu - San Jose CA, US
Vanitha Ramakrishnan - Belmont CA, US

Assignee:

Protein Design Labs, Inc. - Fremont CA

International Classification:

A61K 51/00
A61K 39/395

US Classification:

424001490, 424130100

Abstract:

The present invention is directed to stable protein derivatives, e.g., antibodies, antibody fragments or peptides, with at least one free thiol group coupled to N-acetyl-L-cysteine, N-ethyl-maleimide, or cysteine and the methods of making such derivatives. In addition, stable liquid pharmaceutical formulations comprising such proteins or their derivatives and stable lyophilized pharmaceutical formulations comprising such proteins are provided. The present invention is also directed to a method of making a stable Fab′ fragment of an antibody and a method of controlling vascularization in injured or cancerous tissue comprising applying to the injured tissue one or more doses of the pharmaceutical formulations.