Paul P Actor

US Patent:

6380161, Apr 30, 2002

Filed:

Jun 20, 2000

Appl. No.:

09/597766

Inventors:

Taffy Williams - Lansdale PA
George Tuszynski - Pittsgrove NJ
Paul Actor - Phoenixville PA

Assignee:

Inkine Pharmaceutical Company, Inc. - Blue Bell PA
Philadelphia Health and Education Corporation - Philadelphia PA

International Classification:

A91K 3800

US Classification:

514 12, 514 17, 514 16, 514 15, 514 2, 530327, 530329, 530330, 435 6

Abstract:

The present invention provides methods and compositions for treating cancer and chemotherapy-resistant cancers comprising a chemotherapeutic agent conjugated to or coadministered with a peptide.

US Patent:

20030171298, Sep 11, 2003

Filed:

Oct 3, 2001

Appl. No.:

10/042696

Inventors:

Taffy Williams - Lansdale PA, US
George Tuszynski - Pittsgrove NJ, US
Paul Actor - Phoenixville PA, US

Assignee:

INKINE PHARMACEUTICALS MCP HAHNEMANN

International Classification:

A61K038/10
C07K007/08

US Classification:

514/015000, 530/328000

Abstract:

The present invention relates generally to polypeptides that mimic or inhibit the biological activity of thrombospondin, and particularly to polypeptides in retroinverso form. The peptides. These polypeptides may be used biological and pharmaceutical applications such as: (a) inhibiting the invasive and metastatic activity of melanoma cells, (b) promoting and inhibiting cellular attachment to tissue culture flasks, (c) promoting wound healing, angiogenesis, and implant acceptance, (d) agents for anti-platelet aggregation, (e) agents for antimalarial activity, and (f) diagnostic reagents in different therapeutic applications, as well as other related areas.

US Patent:

6339062, Jan 15, 2002

Filed:

Nov 23, 1998

Appl. No.:

09/197770

Inventors:

Taffy Williams - Lansdale PA
George Tuszynski - Pittsgrove NJ
Paul Actor - Phoenixville PA

Assignee:

Inkine Pharmaceutical Company, Inc. - Blue Bell PA

International Classification:

A61K 3800

US Classification:

514 15, 514 16, 514 17, 530300, 530328, 530329, 530330, 4241851

Abstract:

The present invention relates generally to polypeptides that mimic or inhibit the biological activity of thrombospondin, and particularly to polypeptides in retroinverso form. These polypeptides may be used for their biological and pharmaceutical applications such as: (a) inhibiting the invasive and metastatic activity of melanoma cells, (b) promoting and inhibiting cellular attachment to tissue culture flacks, (c) promoting wound healing, angiogenesis, and implant acceptance, (d) agents for anti-platelet aggregation, (e) agents for antimalarial activity, and (f) diagnostic reagents in different therapeutic applications, as well as other related areas.