Paul A Algate

US Patent:

6699664, Mar 2, 2004

Filed:

Sep 20, 2000

Appl. No.:

09/667857

Inventors:

Jennifer L. Mitcham - Redmond WA
Gordon E. King - Seattle WA
Paul A. Algate - Issaquah WA
Steven P. Fling - Bainbridge Island WA
Marc W. Retter - Carnation WA
Gary R. Fanger - Mill Creek WA
Steven G. Reed - Bellevue WA
Thomas S. Vedvick - Federal Way WA
Darrick Carter - Seattle WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

C12Q 168

US Classification:

435 6, 4352523, 4353201, 435325, 536 231, 536 241

Abstract:

Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.

US Patent:

6710170, Mar 23, 2004

Filed:

Apr 3, 2001

Appl. No.:

09/825294

Inventors:

Jiangchun Xu - Bellevue WA
John A. Stolk - Bothell WA
Paul A. Algate - Issaquah WA
Steven P. Fling - Bainbridge Island WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

C07H 2100

US Classification:

536 231, 536 243, 536 253, 4353201, 435325

Abstract:

Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

US Patent:

6962980, Nov 8, 2005

Filed:

Apr 4, 2001

Appl. No.:

09/827271

Inventors:

Jennifer L. Mitcham - Redmond WA, US
Gordon E. King - Shoreline WA, US
Paul A. Algate - Issaquah WA, US

Assignee:

Corixa Corporation - Seattle WA

International Classification:

C07K016/00
C12P021/08

US Classification:

5303871, 5303877, 5303881

Abstract:

Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.

US Patent:

7202334, Apr 10, 2007

Filed:

Aug 10, 2000

Appl. No.:

09/636801

Inventors:

Jennifer L. Mitcham - Redmond WA, US
Gordon E. King - Seattle WA, US
Paul A. Algate - Issaquah WA, US
Steven P. Fling - Bainbridge Island WA, US
Marc W. Retter - Carnation WA, US
Gary R. Fanger - Mill Creek WA, US
Steven G. Reed - Bellevue WA, US

Assignee:

Corixa Corporation - Hamilton MT

International Classification:

A61K 39/00

US Classification:

530350, 530828, 4241841, 4241851, 4242771, 436501, 436 64, 436813, 435 71

Abstract:

Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.

US Patent:

8071732, Dec 6, 2011

Filed:

Oct 2, 2006

Appl. No.:

11/542681

Inventors:

Alexander Gaiger - Vienna, AT
Paul A. Algate - Issaquah WA, US
Jane Mannion - Newbury Park CA, US
Jonathan D. Clapper - University Place WA, US
Aijun Wang - Issaquah WA, US
Nadia Ordonez - Seattle WA, US
Lauren Carter - Seattle WA, US
Patricia Dianne McNeill - Federal Way WA, US

Assignee:

Corixa Corporation - Seattle WA

International Classification:

C12P 21/08

US Classification:

5303881

Abstract:

Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of a variety of leukemias and lymphomas.

US Patent:

20020022591, Feb 21, 2002

Filed:

Feb 5, 2001

Appl. No.:

09/777564

Inventors:

Paul Algate - Issaquah WA, US
Jane Mannion - Edmonds WA, US

International Classification:

A61K048/00
A61K038/00
C07H021/04
C12P021/02
C12Q001/68

US Classification:

514/012000, 514/044000, 436/006000, 435/069100, 536/023100, 530/350000, 435/006000

Abstract:

Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses an ovarian tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Diagnostic methods based on detecting an ovarian tumor protein, or mRNA encoding such a protein, in a sample are also provided.

US Patent:

20020102679, Aug 1, 2002

Filed:

May 23, 2001

Appl. No.:

09/864864

Inventors:

Jiangchun Xu - Bellevue WA, US
Jennifer Mitcham - Redmond WA, US
Susan Harlocker - Seattle WA, US
Davin Dillon - Issaquah WA, US
Heather Secrist - Seattle WA, US
Michael Lodes - Seattle WA, US
Paul Algate - Issaquah WA, US
Steven Fling - Bainbridge Island WA, US
Jane Mannion - Edmonds WA, US
Darin Benson - Seattle WA, US
Darrick Carter - Seattle WA, US

International Classification:

C12N009/00
C07H021/04
C07K014/435
C12P021/02

US Classification:

435/183000, 435/320100, 435/325000, 435/069100, 536/023100

Abstract:

Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses an ovarian tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Diagnostic methods based on detecting an ovarian tumor protein, or mRNA encoding such a protein, in a sample are also provided.

US Patent:

20020110563, Aug 15, 2002

Filed:

Dec 14, 2000

Appl. No.:

09/738973

Inventors:

Steven Reed - Bellevue WA, US
Michael Lodes - Seattle WA, US
Raodoh Mohamath - Seattle WA, US
Heather Secrist - Seattle WA, US
Darin Benson - Seattle WA, US
Carol Indirias - Seattle WA, US
Robert Henderson - Edmonds WA, US
Steven Fling - Bainbridge Island WA, US
Paul Algate - Issaquah WA, US
Mark Elliott - Seattle WA, US
Jane Mannion - Edmonds WA, US
Michael Kalos - Seattle WA, US

International Classification:

C12Q001/68
G01N033/574
C07H021/04
A61K039/395
C12P021/02
C12N005/06

US Classification:

424/155100, 435/006000, 435/007230, 435/069100, 435/183000, 435/325000, 435/320100, 536/023100

Abstract:

Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.