Paul R Brodfuehrer

US Patent:

6353122, Mar 5, 2002

Filed:

Feb 4, 1998

Appl. No.:

09/018425

Inventors:

Paul R. Brodfuehrer - Syracuse NY

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D30102

US Classification:

549518, 568338

Abstract:

The present invention provides a process for the expoxidation of a protected 3-methylene-(trans)-1,2,-hydroxymethylcyclopropane with cyclohexanone and potassium peroxymonosulfate and subsequent rearrangement to provide the corresponding cyclobutanone.

US Patent:

6875867, Apr 5, 2005

Filed:

May 30, 2002

Appl. No.:

10/158355

Inventors:

Paul R. Brodfuehrer - Syracuse NY, US
Thomas R. Sattelberg - Cicero NY, US
Joydeep Kant - Cherry Hill NJ, US
Xinhua Qian - Pennington NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D239/42
C07D221/16
C07D213/55
C07D207/34
C07C067/327

US Classification:

540577, 544297, 546 80, 546 89, 546 93, 546173, 546342, 548502, 548537, 560119

Abstract:

A process is provided for preparing chiral diol sulfones of the structure where Ris preferably where Ris preferably aryl such as phenyl, and Ris preferably alkyl such as t-butyl, which are intermediates used in preparing HMG CoA reductase inhibitors.

US Patent:

20050124641, Jun 9, 2005

Filed:

Jan 20, 2005

Appl. No.:

11/039702

Inventors:

Paul Brodfuehrer - Syracuse NY, US
Thomas Sattleberg - Cicero NY, US
Joydeep Kant - Cherry Hill NJ, US
Xinhua Qian - Pennington NJ, US

International Classification:

C07D221/16
A61K031/505
A61K031/473
A61K031/401

US Classification:

514275000, 514290000, 514381000, 514367000, 514375000, 514423000, 514460000, 514548000, 544330000, 546093000, 548537000, 549292000

Abstract:

A process is provided for preparing chiral diol sulfones of the structure where Ris preferably where Ris preferably aryl such as phenyl, and Ris preferably alkyl such as t-butyl, which are intermediates used in preparing HMG CoA reductase inhibitors.

US Patent:

48682942, Sep 19, 1989

Filed:

Mar 23, 1987

Appl. No.:

7/044529

Inventors:

Steven P. Brundidge - Wolcott NY
Paul R. Brodfuehrer - Syracuse NY
Chet Sapino - East Syracuse NY
Kun M. Shih - East Syracuse NY
Donald G. Walker - Liverpool NY

Assignee:

Bristol-Myers Company - New York NY

International Classification:

C07D50146
A61K 31545

US Classification:

540222

Abstract:

Processes for the preparation of stable, crystalline cephalosporin intermediates of the formula ##STR1## wherein X is HI or HCl, and Nu and Nu. sup. sym. are certain N-containing heterocyclic rings attached via a sulfur atom or a ring nitrogen atom, respectively, which are substantially free of the. DELTA. sup. 2 isomer; processes for intermediates in the preparation of the above compounds; and processes for the preparation of broad-spectrum cephalosporin antibiotics.

US Patent:

47147601, Dec 22, 1987

Filed:

Jul 11, 1986

Appl. No.:

6/882107

Inventors:

Steven P. Brundidge - Wolcott NY
Paul R. Brodfuehrer - Syracuse NY
Chet Sapino - East Syracuse NY
Kun M. Shih - East Syracuse NY
Donald G. Walker - Liverpool NY

Assignee:

Bristol-Myers Company - New York NY

International Classification:

C07D50118

US Classification:

540222

Abstract:

Stable, crystalline cephalosporin intermediates of the formula ##STR1## wherein X is HI or HCl and Nu and Nu. sup. sym. are certain N-containing heterocyclic rings attached via a sulfur atom or a ring nitrogen atom, respectively, which are substantially free of the. DELTA. sup. 2 isomer; processes for, and intermediates in, the preparation of the above compounds; and processes for the preparation of broad-spectrum cephalosporin antibiotics.

US Patent:

55525423, Sep 3, 1996

Filed:

May 10, 1995

Appl. No.:

8/438322

Inventors:

J. Gregory Reid - Manlius NY
Paul R. Brodfuehrer - Syracuse NY
Patrick R. Smith - Syracuse NY

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D50118

US Classification:

540217

Abstract:

This invention relates to a method of producing 3-alkanoyloxymethyl-3-cephem-4-carboxylic acids from 3-hydroxymethyl-3-cephem-4-carboxylic acids in an aqueous medium for a practical, large-scale production. Moreover, the invention provides an ideal intermediate for the process.

US Patent:

56376944, Jun 10, 1997

Filed:

Apr 5, 1996

Appl. No.:

8/628426

Inventors:

J. Gregory Reid - Manlius NY
Paul R. Brodfuehrer - Syracuse NY
Patrick R. Smith - Syracuse NY

Assignee:

Briston-Myers Squibb Company - Princeton NY

International Classification:

E07D50128

US Classification:

540230

Abstract:

This invention relates to a method of producing 3-alkanoyloxymethyl-3-cephem-4-carboxylic acids from 3-hydroxymethyl-3-cephem-4-carboxylic acids in an aqueous medium for a practical, large-scale production. Moreover, the invention provides an ideal intermediate for the process.

US Patent:

50117742, Apr 30, 1991

Filed:

Feb 28, 1990

Appl. No.:

7/486701

Inventors:

Vittorio Farina - West Hartford CT
Daniel A. Benigni - Elbridge NY
Paul R. Brodfuehrer - Syracuse NY

Assignee:

Bristol-Myers Squibb Co. - New York NY

International Classification:

C12P 1938
C12P 1940
C12N 996
C12N 978

US Classification:

435 87

Abstract:

A novel process utilizing adenosine deaminase to selectively produce. beta. -(D)-2',3'-dideoxyinosine in high yields from an. alpha. ,. beta. -anomeric mixture. . beta. -(D)-2',3'-Dideoxyinosine so produced is useful as an antiviral and antibiotic agent.