Paul R Cavanaugh

US Patent:

55678106, Oct 22, 1996

Filed:

May 31, 1995

Appl. No.:

8/456017

Inventors:

Alexander L. Weis - Berwyn PA
Fred T. Oakes - Rochester NY
Frederick H. Hausheer - San Antonio TX
Paul F. Cavanaugh - West Chester PA
Patricia S. Moskwa - Phoenixville PA

Assignee:

Sterling Drug, Inc. - New York NY

International Classification:

C07H 2100
A61K 31045
A61K 31715
C07C 3120

US Classification:

536 253

Abstract:

Compounds, compositions and methods for inhibiting gene expression are disclosed. The compounds comprise oligonucleotide sequences of from about 9 to about 200 bases having a diol at either or both termini. Preferred diols are polyalkyleneglycols, preferably polyethyleneglycols. Pharmaceutical compositions comprising the compounds and a physiologically acceptable carrier and methods of inhibiting gene expression in mammals comprising administering such compounds are also provided. Methods for inhibiting nuclease cleavage of compounds are also provided.

US Patent:

56774397, Oct 14, 1997

Filed:

May 24, 1995

Appl. No.:

8/449124

Inventors:

Alexander Ludvik Weis - Berwyn PA
Frederick Herman Hausheer - San Antonio TX
Prasad Venkata Chala Chaturvedula - Exton PA
Daniel Joseph Delecki - Radnor PA
Paul Francis Cavanaugh - West Chester PA
Patricia Susan Moskwa - Phoenixville PA
Fred Terry Oakes - Rochester NY

Assignee:

Sanofi - Paris

International Classification:

C07H 2104

US Classification:

536 231

Abstract:

The present invention relates to compounds, compositions and methods for inhibiting gene expression. The compounds of this invention comprise 1) oligonucleoside sequences of from about 6 to about 200 bases having a three atom internucleoside linkage or 2) oligonucleotide sequences of from about 9 to about 200 bases having a diol at either or both termini.

US Patent:

52450228, Sep 14, 1993

Filed:

Aug 3, 1990

Appl. No.:

7/562180

Inventors:

Alexander L. Weis - Berwyn PA
Fred T. Oakes - Rochester NY
Frederick H. Hausheer - San Antonio TX
Paul F. Cavanaugh - West Chester PA
Patricia S. Moskwa - Phoenixville PA

Assignee:

Sterling Drug, Inc. - New York NY

International Classification:

C07H 2100

US Classification:

536 245

Abstract:

Compounds, compositions and methods for inhibiting gene expression are disclosed. The compounds comprise oligonucleotide sequences of from about 9 to about 200 bases having a diol at either or both termini. Preferred diols are polyalkyleneglycols, preferably polyethyleneglycols. Pharmaceutical compositions comprising the compounds and a physiologically acceptable carrier and methods of inhibiting gene expression in mammals comprising administering such compounds are also provided. Methods for inhibiting nuclease cleavage of compounds are also provided.