Paul P Devine

US Patent:

6353110, Mar 5, 2002

Filed:

Nov 24, 1999

Appl. No.:

09/448775

Inventors:

Paul N. Devine - Lincroft NJ
Richard D. Tillyer - Westfield NJ
David M. Tschaen - Holmdel NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D40306

US Classification:

5462837, 546301, 546340, 546341, 546342

Abstract:

This invention relates to a key intermediate in the synthesis of an endothelin antagonist the synthesis of this key intermediate via an asymmetric conjugate addition reaction.

US Patent:

6504066, Jan 7, 2003

Filed:

Jun 30, 2000

Appl. No.:

09/607229

Inventors:

Paul Devine - Lincroft NJ
Hansen Karl - Atlantic Highlands NJ

Assignee:

Merck Co. Inc. - Rahway NJ

International Classification:

C07C 3346

US Classification:

568812, 544351, 556137

Abstract:

The present invention is concerned with novel processes for the preparation of (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

US Patent:

6531617, Mar 11, 2003

Filed:

Oct 24, 2001

Appl. No.:

10/001369

Inventors:

Karl Hansen - Atlantic Highlands NJ
Paul Devine - Lincroft NJ
Philippe M. Rabbat - New York NY

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D31122

US Classification:

549400, 549401

Abstract:

Enantiomerically enriched hydroxychromanones are obtained by the AlCl -catalyzed intramolecular Friedel-Crafts acylation of the corresponding 3-phenoxy-2-alkylcarbonyloxy-propionic acid followed by cleavage of the carboxylate in the presence of an alkali metal peroxide or hydroperoxide. Enantiomerically enriched cis-aminochromanols can then be prepared by treating the hydroxychromanones with a hydroxylamine and hydrogenating the resulting oxime. The cis-aminochromanols can be employed as intermediates in the production of HIV protease inhibitors which are useful for treating HIV infection and AIDS.

US Patent:

6777580, Aug 17, 2004

Filed:

Dec 20, 2002

Appl. No.:

10/324956

Inventors:

Paul Devine - Lincroft NJ
Hansen Karl - Atlantic Highlands NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07C 3346

US Classification:

568812

Abstract:

The present invention is concerned with novel processes for the preparation of (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

US Patent:

7429674, Sep 30, 2008

Filed:

Apr 14, 2005

Appl. No.:

11/106214

Inventors:

Paul Devine - Tinton Falls NJ, US
John Limanto - Rahway NJ, US
Ali Shafiee - Westfield NJ, US
Veena Upadhyay - Westfield NJ, US

Assignee:

Merck & Co. Inc.. - Rahway NJ

International Classification:

C07C 229/00
C07C 205/00

US Classification:

560155, 562553, 560172

Abstract:

This invention relates to a stereoselective preparation of fluoroleucine alkyl esters.

US Patent:

7923459, Apr 12, 2011

Filed:

Apr 10, 2007

Appl. No.:

11/733512

Inventors:

Donald R. Gauthier - Westfield NJ, US
Richard Desmond - Lebanon NJ, US
Paul N. Devine - Tinton Falls NJ, US

Assignee:

NSAB, Filial AF Neurosearch Sweden AB, Sverige - Ballerup

International Classification:

A61K 31/445

US Classification:

514317

Abstract:

The present invention is directed to processes for the preparation of 4-(3-methanesulfonyl-phenyl)-1-N-propylpiperidine (I) or a pharmaceutically acceptable salt thereof, which comprises: oxidizing a sulfide of the formula (II): with a catalytic oxidizing agent and an oxidant; to give a compound of the formula (III): followed by catalytic reduction of the compound of formula (III).

US Patent:

20120190085, Jul 26, 2012

Filed:

Jun 21, 2010

Appl. No.:

13/378963

Inventors:

Gregory Hughes - Rahway NJ, US
Paul N. Devine - Rahway NJ, US
Fred J. Fleitz - Rahway NJ, US
Brendan T. Grau - Rahway NJ, US
John Limanto - Rahway NJ, US
Christopher Savile - Redwood City CA, US
Emily Mundorff - Poughkeepsie NY, US

Assignee:

CODEXIS, INC. - Redwood City CA

International Classification:

C12P 13/00
C12P 17/10
C12P 17/12

US Classification:

435122, 435128, 435121

Abstract:

The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.

US Patent:

57081867, Jan 13, 1998

Filed:

Dec 6, 1996

Appl. No.:

8/761175

Inventors:

Paul N. Devine - Rahway NJ
David M. Tschaen - Rahway NJ
Richard M. Heid - Rahway NJ

International Classification:

C07D295192
C07D31760
C07D40712

US Classification:

548426

Abstract:

This invention relates to a method for the stereoselective synthesis of a 2-aryloxycarboxylic acid using a chiral auxiliary to enhance the stereoselectivity of the alkylation of the. alpha. -halo acid with an aryloxy group.

Address:

268 Edge Hl Rd, Milton, MA 02186

Phone:

6176960851

VIN:

5TFUM5F18AX010738

Make:

TOYOTA

Model:

TUNDRA

Year:

2010