Ian Davies - Princeton NJ Karl Hansen - Atlantic Highlands NJ Paul N. Devine - Lincroft NJ Louis Matty, Jr. - Hillsborough NJ Yuan Cheng - Edison NJ Philippe M. Rabbat - Baie dUrfe, CA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
C07D31104
US Classification:
549399
Abstract:
cis-aminochromanols are obtained in high yield and with high selectivity over their trans counterparts by hydrogenating the corresponding oximes in the presence of a catalyst and an acid selected from HBr, HCl, and organic sulfonic acid. The cis-aminochromanols can be employed as intermediates in the production of HIV protease inhibitors which are useful for treating HIV infection and AIDS.
Cheng Yi Chen - Plainsboro NJ, US Paul N. Devine - Tinton Falls NJ, US Bruce S. Foster - Scotch Plains NJ, US Greg Hughes - Beaconsfield, CA Paul O'Shea - Westmount, CA
Assignee:
Merck Frosst Canada Ltd. - Quebec
International Classification:
C07C 229/00
US Classification:
560 40
Abstract:
This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with α-aminoesters under basic conditions to form metal carboxylates. Diastereoselective reductions of the metal carboxylates enable access to two diastereomers, depending on the reducing conditions.
Process For The Synthesis Of 4-(3-Methanesulfonylphenyl)-1-N-Propyl-Piperidine
Donald R. Gauthier - Westfield NJ, US Richard Desmond - Lebanon NJ, US Paul N. Devine - Tinton Falls NJ, US
Assignee:
NSAB, Filial AF Neurosearch Sweden AB, Sverige - Ballerup
International Classification:
A61K 31/445
US Classification:
514317
Abstract:
The present invention is directed to processes for the preparation of 4-(3-methanesulfonyl-phenyl)-1-N-propylpiperidine (I) or a pharmaceutically acceptable salt thereof, which comprises: oxidizing a sulfide of the formula (II): with a catalytic oxidizing agent and an oxidant; to give a compound of the formula (III): followed by catalytic reduction of the compound of formula (III).
Process For The Synthesis Of 4-(3-Sulfonylphenyl)-Piperidines
Richard Desmond - Lebanon NJ, US Paul Devine - Tinton Falls NJ, US Clas Sonesson - Billdal, SE Donald Gauthier - Westfield NJ, US
International Classification:
C07D 211/18
US Classification:
546232000
Abstract:
The present invention is directed to processes for the preparation of 4-(sulfonylphenyl)-piperidines of the Formula (VI), and pharmaceutically acceptable salts thereof; which comprises oxidizing a sulfide of the Formula (VII) or Formula (VIII), to give a compound of the Formula (IX) or Formula (X) respectively, followed by catalic reduction of the compound of the Formula (IX) or dehydration of compound of formula (X) to give a compound of Formula (IX) followed by catalytic reduction of the compound formula (IX) to give the compound of the Formula (VI).
Gregory Hughes - Rahway NJ, US Paul N. Devine - Rahway NJ, US Fred J. Fleitz - Rahway NJ, US Brendan T. Grau - Rahway NJ, US John Limanto - Rahway NJ, US Christopher Savile - Redwood City CA, US Emily Mundorff - Poughkeepsie NY, US
Assignee:
CODEXIS, INC. - Redwood City CA
International Classification:
C12P 13/00 C12P 17/10 C12P 17/12
US Classification:
435122, 435128, 435121
Abstract:
The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.
Paul N. Devine - Rahway NJ David M. Tschaen - Rahway NJ Richard M. Heid - Rahway NJ
International Classification:
C07D295192 C07D31760 C07D40712
US Classification:
548426
Abstract:
This invention relates to a method for the stereoselective synthesis of a 2-aryloxycarboxylic acid using a chiral auxiliary to enhance the stereoselectivity of the alkylation of the. alpha. -halo acid with an aryloxy group.
Michel M. Chartrain - Westfield NJ Barbara A. Krulewicz - Bloomfield NJ Paul N. Devine - Lincroft NJ David M. Tschaen - Holmdel NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C12P 700 C07D31744
US Classification:
435132
Abstract:
The invention relates to a class of enantiomerically pure intermediates represented by Formula I, where X is F, Cl, Br, or I, and a novel enantioselective bioreductive process using yeast to form these intermediates, which are useful in the synthesis of endothelin antagonists, and the like. ##STR1##.
Process For The Preparation Of An Endothelin Antagonist
Vail Pittman Elementary School Las Vegas NV 1972-1978, Kermit R. Booker Elementary School Las Vegas NV 1978-1978, Frank F. Garside Junior High School Las Vegas NV 1979-1981
Community:
Donna Koon, Jennifer Lambert, Tracy Shelton, Karen Scharer, Sabra Michelle
Ben Franklin Elementary School Kansas City MO 1963-1971, West Junior High School Kansas City MO 1967-1971, Marceline High School Marceline MO 1971-1976
Community:
Phillip Wead, Linda Richeson, Paul Coram, Rich Sturgess, Georgia Lewis, Denise Edgar, Cathy Nolan, Sandra Thurman, Jane Shermuly, Ron Stella, Jonnie Lewis
"Childress Klein and Springs are excited about the opportunity to create a new national headquarters campus for The Lash Group that will help the company achieve its business objectives and realize its growth potential," said Paul Devine, Partner, Chil
Date: Jun 16, 2014
Category: Business
Source: Google
Ex-Apple manager pleads guilty to $2.3M kickback scheme
S. Attorney Melinda Haag said that Paul Devine, formerly a global supply manager at Apple, admitted to taking kickbacks. In return, Devine provided accessory suppliers with confidential Apple documents -- including sales forecasts, price targets and unreleased product specifications -- that gave the
Date: Mar 01, 2011
Category: Sci/Tech
Source: Google
Former Apple Exec Pleads Guilty to Wire Fraud Over Kickback Scheme
Paul Devine admitted to a scheme that defrauded Apple between 2005 and 2010, according to the U.S. Attorney's Office. Devine also admitted to transferring the proceeds from his scam between various bank accounts in the U.S. and overseas in order to hide his activity.
She was a member of Berryville Presbyterian Church and the Blue Ridge Democratic Women Committee. She loved animals and was an avid bird watcher. She married James Paul Devine Jr., on Jan. 15, 1953, in Berryville. Mr. Devine died on Oct. 25, 2005. ...
Pall Mall event celebrates Tennessee cultural arts and heritage
Among the artists demonstrating are Mary Curren, who spins llama hair into wearable creations; Natali and Paul Devine, a husband and wife team who make colorful hand-dyed baskets using reeds and white oak; and Julie Styer, whose talents include wood ...
First defeat for Dromard as Slashers come out on top
LONGFORD SLASHERS: Paddy McKeon; Peter Brady, Barry Gilleran, Gareth Ghee; Thomas O'Rourke, Dermot Brady, Paul Devine; Niall Mulligan (0-1), David Sheridan; Brian Farrell, Paul Kelly, Trevor Clendenning (0-4); Martin Nevin, Colin Smith (1-4, ...
Lackawanna County athletes among those honored for GPAs of 3.5 or better were: Christopher Conte (tennis), Paul Devine (cross country/track), Dan Gavin (golf), Heather Godino (tennis), Dave Krajewski (track), Courtney Lance (tennis), ...
Paul Devine, West Midlands regional secretary for PCS at the Department of Work and Pensions, was on the picket line in Telford this morning. He said: This dispute is about staff having to meet targets on new claims. Staff are expected to spend no ...
Youtube
Thief, Addict, Prisoner, Father | Paul Devine
Paul recalls how his life changed upon encountering a Salvation Army r...
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3m 28s
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"Most beautiful, Relaxing, music for Autumn" by Paul Devine. Protected...
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The Pelosis are very powerful people: Miranda...
'Laptop from Hell' author Miranda Devine discusses Paul Pelosi's upcom...
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1m 42s
Paul Devine RIP
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3m 15s
There is a River - Paul Devine
Welcome friend. There is a River talks about the Salavtion of Jesus. W...
Duration:
3m 41s
Under our Sky - Original music and poetry by ...
"Under our Sky" words and music by Paul Devine. Copyrighted July 15, 2...