Paul M Devine

US Patent:

6353110, Mar 5, 2002

Filed:

Nov 24, 1999

Appl. No.:

09/448775

Inventors:

Paul N. Devine - Lincroft NJ
Richard D. Tillyer - Westfield NJ
David M. Tschaen - Holmdel NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D40306

US Classification:

5462837, 546301, 546340, 546341, 546342

Abstract:

This invention relates to a key intermediate in the synthesis of an endothelin antagonist the synthesis of this key intermediate via an asymmetric conjugate addition reaction.

US Patent:

6384244, May 7, 2002

Filed:

May 11, 2001

Appl. No.:

09/853796

Inventors:

Ian Davies - Princeton NJ
Karl Hansen - Atlantic Highlands NJ
Paul N. Devine - Lincroft NJ
Louis Matty, Jr. - Hillsborough NJ
Yuan Cheng - Edison NJ
Philippe M. Rabbat - Baie dUrfe, CA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D31104

US Classification:

549399

Abstract:

cis-aminochromanols are obtained in high yield and with high selectivity over their trans counterparts by hydrogenating the corresponding oximes in the presence of a catalyst and an acid selected from HBr, HCl, and organic sulfonic acid. The cis-aminochromanols can be employed as intermediates in the production of HIV protease inhibitors which are useful for treating HIV infection and AIDS.

US Patent:

6504066, Jan 7, 2003

Filed:

Jun 30, 2000

Appl. No.:

09/607229

Inventors:

Paul Devine - Lincroft NJ
Hansen Karl - Atlantic Highlands NJ

Assignee:

Merck Co. Inc. - Rahway NJ

International Classification:

C07C 3346

US Classification:

568812, 544351, 556137

Abstract:

The present invention is concerned with novel processes for the preparation of (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

US Patent:

6531617, Mar 11, 2003

Filed:

Oct 24, 2001

Appl. No.:

10/001369

Inventors:

Karl Hansen - Atlantic Highlands NJ
Paul Devine - Lincroft NJ
Philippe M. Rabbat - New York NY

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D31122

US Classification:

549400, 549401

Abstract:

Enantiomerically enriched hydroxychromanones are obtained by the AlCl -catalyzed intramolecular Friedel-Crafts acylation of the corresponding 3-phenoxy-2-alkylcarbonyloxy-propionic acid followed by cleavage of the carboxylate in the presence of an alkali metal peroxide or hydroperoxide. Enantiomerically enriched cis-aminochromanols can then be prepared by treating the hydroxychromanones with a hydroxylamine and hydrogenating the resulting oxime. The cis-aminochromanols can be employed as intermediates in the production of HIV protease inhibitors which are useful for treating HIV infection and AIDS.

US Patent:

6777580, Aug 17, 2004

Filed:

Dec 20, 2002

Appl. No.:

10/324956

Inventors:

Paul Devine - Lincroft NJ
Hansen Karl - Atlantic Highlands NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07C 3346

US Classification:

568812

Abstract:

The present invention is concerned with novel processes for the preparation of (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

US Patent:

7183425, Feb 27, 2007

Filed:

Jul 29, 2005

Appl. No.:

11/193798

Inventors:

Cheng Yi Chen - Plainsboro NJ, US
Paul N. Devine - Tinton Falls NJ, US
Bruce S. Foster - Scotch Plains NJ, US
Greg Hughes - Beaconsfield, CA
Paul O'Shea - Westmount, CA

Assignee:

Merck Frosst Canada Ltd. - Quebec

International Classification:

C07C 229/00

US Classification:

560 40

Abstract:

This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with α-aminoesters under basic conditions to form metal carboxylates. Diastereoselective reductions of the metal carboxylates enable access to two diastereomers, depending on the reducing conditions.

US Patent:

7429674, Sep 30, 2008

Filed:

Apr 14, 2005

Appl. No.:

11/106214

Inventors:

Paul Devine - Tinton Falls NJ, US
John Limanto - Rahway NJ, US
Ali Shafiee - Westfield NJ, US
Veena Upadhyay - Westfield NJ, US

Assignee:

Merck & Co. Inc.. - Rahway NJ

International Classification:

C07C 229/00
C07C 205/00

US Classification:

560155, 562553, 560172

Abstract:

This invention relates to a stereoselective preparation of fluoroleucine alkyl esters.

US Patent:

7895475, Feb 22, 2011

Filed:

Nov 21, 2007

Appl. No.:

11/943925

Inventors:

Mihir Arvind Kulkarni - Fremont CA, US
Rajendra Inamdar - N. Chelmsford MA, US
Rao Nasir Khan - Fremont CA, US
Jaroslaw Wilkiewicz - Menlo Park CA, US
Paul James Devine - San Francisco CA, US

Assignee:

Oracle International Corporation - Redwood Shores CA

International Classification:

G06F 11/00

US Classification:

714 47, 714 25, 714 38

Abstract:

An instrumentation service is described that uses dye injection and filtering in a Session Initiation Protocol (SIP) application server environment. The instrumentation service can provide a flexible mechanism for selectively adding diagnostic code to the SIP application server and the various applications running on it. It can allow flexible selection of locations in the server and application code, at which instrumentation code can be added. The process of adding diagnostic code can be deferred to the time of running the server at the deployment site. The instrumentation service further allows flexible selection of diagnostic actions, which can be executed at selected locations. In various embodiments, the execution of diagnostic code can be dynamically enabled or disabled while the server is running. Also, the behavior of diagnostic code executed at such locations can be dynamically changed while the server is running.