Paul J Hung from Palo Alto, CA, age 49

Microwell Cell-Culture Device And Fabrication Method
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US Patent:

8257964, Sep 4, 2012
Filed:

Dec 29, 2006
Appl. No.:

11/648207
Inventors:

Paul Ju-Sung Hung - Fremont CA, US
Philip Janmin Lee - Alameda CA, US
Assignee:

Cell ASIC - San Leandro CA
International Classification:

C12M 1/34
US Classification:

4352871, 422502, 156228, 264226
Abstract:

Methods for fabricating microfluidics devices, microfluidics cell-culture device and systems having a substrate, a microchannel through which liquid can be moved from one station to another within the device, the fabrication methods using semi-rigid materials during molding that are incorporated into the final device.

Microfluidic Particle Analysis Method, Device And System
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US Patent:

20080194012, Aug 14, 2008
Filed:

Jan 25, 2008
Appl. No.:

12/019857
Inventors:

Philip Janmin Lee - Alameda CA, US
Paul Ju-Sung Hung - Fremont CA, US
Narendra Maheshri - Cambridge MA, US
Assignee:

CellASIC Corporation - San Leandro CA
International Classification:

C12M 1/34
B01J 19/00
US Classification:

4352871, 422 681
Abstract:

The method, device, and system relate to particle analysis, and in particular, to a microfluidic device designed for trapping particles for analysis. Particles include beads and cells.

Methods And Apparatus For Cell Culture Array
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US Patent:

20090023608, Jan 22, 2009
Filed:

Jul 6, 2006
Appl. No.:

11/994997
Inventors:

Paul J. Hung - Berkeley CA, US
Philip J. Lee - Berkeley CA, US
Luke P. Lee - Orinda CA, US
International Classification:

C40B 50/18
C40B 60/14
US Classification:

506 32, 506 40
Abstract:

Method and systems that provide improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays.

Cell Culture Array System For Automated Assays And Methods Of Operation And Manufacture Thereof
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US Patent:

20090203126, Aug 13, 2009
Filed:

Jan 5, 2009
Appl. No.:

12/348907
Inventors:

Paul J. Hung - Berkeley CA, US
Philip J. Lee - Alameda CA, US
International Classification:

C12N 5/02
C12M 3/00
US Classification:

435325, 4352891
Abstract:

A number of novel improved microfluidic configurations and systems and methods of manufacture and operation. In one embodiment, three wells are used for independent cell culture systems in a cell culture array. In a second aspect, artificial sinusoids with artificial epithelial barriers are provided with just one (optionally shared or multiplexed) fluidic inlet and one (optionally shared or multiplexed) fluidic output, where the medium output also functions as a cellular input. A pneumatic cell loader combined with other components provides a fully automated cell culture system. Magnetic alignment of plate molds provides advantages and ease of molded manufacture.

Microfluidic Cell Culture Systems
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US Patent:

20120003732, Jan 5, 2012
Filed:

Jan 21, 2011
Appl. No.:

13/011857
Inventors:

Paul J. Hung - Berkeley CA, US
Philip J. Lee - Alameda CA, US
Assignee:

CellASIC, INC. - Hayward CA
International Classification:

C12M 3/00
C12M 1/00
US Classification:

4352891
Abstract:

A number of novel improved microfluidic configurations and systems and methods of manufacture and operation.

Valved, Microwell Cell-Culture Device And Method
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US Patent:

20130081757, Apr 4, 2013
Filed:

Sep 4, 2012
Appl. No.:

13/602331
Inventors:

Paul Ju-Sung Hung - Fremont CA, US
Philip Janmin Lee - Alameda CA, US
Assignee:

CellASIC - Hayward CA
International Classification:

B29C 65/00
US Classification:

156292
Abstract:

A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells.

Valved, Microwell Cell-Culture Device And Method
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US Patent:

20130090268, Apr 11, 2013
Filed:

Sep 4, 2012
Appl. No.:

13/602328
Inventors:

Paul Ju-sung HUNG - Fremont CA, US
Philip Janmin LEE - Alameda CA, US
International Classification:

C12M 1/00
US Classification:

506 37
Abstract:

A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells.

Microfluidic Particle Analysis Method, Device And System
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US Patent:

20180275043, Sep 27, 2018
Filed:

Apr 20, 2018
Appl. No.:

15/958480
Inventors:

- Burlington MA, US
Paul Ju-Sung Hung - Fremont CA, US
Narendra Maheshri - Cambridge MA, US
International Classification:

G01N 15/14
B01L 3/00
G01N 33/487
G01N 33/543
G01N 15/00
Abstract:

The method, device, and system relate to particle analysis, and in particular, to a microfluidic device designed for trapping particles for analysis. Particles include beads and cells.