Jie Yang - Woodbury MN, US Sumita B. Mitra - West St. Paul MN, US Yi He - Roseville MN, US Brian A. Shukla - Woodbury MN, US Naimul Karim - Maplewood MN, US Afshin Falsafi - Woodbury MN, US Richard B. Ross - Cottage Grove MN, US Paul R. Klaiber - Mahtomedi MN, US George W. Griesgraber - Eagan MN, US
Substituted saccharide compounds, dental compositions comprising substituted saccharide compounds, and methods of using dental compositions are described. In one embodiment, the substituted saccharide amide compound comprises a hydrophobic group and at least one free-radically polymerizable group with the proviso that the hydrophobic group is not bonded to the ethylenically unsaturated carbon atom of the free-radically polymerizable group. The hydrophobic group is typically bonded to a nitrogen atom of a saccharide amine residue or a carbonyl moiety of saccharide amide residue.
- St. Paul MN, US Jie Yang - Woodbury MN, US Petra L. Kohler Riedi - Minneapolis MN, US Jodi L. Connell - St. Paul MN, US Ingo Haeberlein - Weilheim, DE Hannah C. Cohen - St. Paul MN, US Katie F. Wlaschin - St. Paul MN, US Paul R. Klaiber - Mahtomedi MN, US Yizhong Wang - Woodbury MN, US Joel D. Oxman - Minneapolis MN, US Tiffany T. Ton - Woodbury MN, US Roxanne A. Boehmer - Lino Lakes MN, US
International Classification:
A61K 8/60 A61K 8/04 A61Q 11/00
Abstract:
A composition comprising from 1 wt-% to 3 wt-% total of glucosamine a derivative of glucosamine, or a combination thereof based on the total weight of the composition, and from 0.3 wt-% to 3 wt-% total of one or more surfactants, based on the total weight of the composition, of Formula (I): HOCH—(OHOH)—CHNRR(I) wherein Rand Rare independently selected from the group consisting of a hydrogen atom, an alkyl group, C(O)Rand SORwith Rand Rbeing independently selected from the group consisting of an alkyl group, an aryl group and an aralkyl group, wherein n is an integer from 2 to 5.
- St. Paul MN, US Jie Yang - Woodbury MN, US Petra L. Kohler Riedi - Minneapolis MN, US Jodi L. Connell - St. Paul MN, US Ingo Haeberlein - St. Paul MN, US Katie F. Wlaschin - St. Paul MN, US Hannah C. Cohen - St. Paul MN, US Tiffany T. Ton - Woodbury MN, US Paul R. Klaiber - Mahtomedi MN, US Yizhong Wang - Woodbury MN, US Joel D. Oxman - Minneapolis MN, US
International Classification:
A61K 8/44 A61K 8/60 A61Q 11/00
Abstract:
A composition comprising: from 0.2 wt-% to 3 wt-% total of arginine, glycine, or a combination thereof based on the total weight of the composition; and from 0.3 wt-% to 3 wt-% total of one or more surfactants, based on the total weight of the composition, of Formula I: HOCH—(CHOH)—CHNRR(I) wherein Rand Rare independently selected from the group consisting of a hydrogen atom, an alkyl group, C(O)R, and SO2R; with Rand Rbeing independently selected from the group consisting of an alkyl group, an aryl group, and an aralkyl group; wherein n is an integer from about 2 to about 5.
Catalase Composition With Improved Stability And Methods
- St. Paul MN, US Steven P. Swanson - Blaine MN, US Paul R. Klaiber - Mahtomedi MN, US
International Classification:
A61K 8/66 C12N 9/08 A61K 8/22 A61Q 11/00
Abstract:
A method of removing calculus from a tooth is described comprising: applying aqueous compositions A and B to the tooth surface, wherein the composition A comprises hydrogen peroxide or a precursor thereto and composition B comprises catalase and a stabilizer comprising hydroxyl groups; and removing at least a part of the calculus from the tooth surface. Preferred stabilizers include dipropylene glycol and 1,3 propane diol. Also described are aqueous compositions and kits.
Dental Appliance With A Surface Having Patterned Glass Ionomer Coating
- St. Paul MN, US Paul R. Klaiber - Mahtomedi MN, US Richard P. Rusin - Woodbury MN, US Yizhong Wang - Woodbury MN, US Kevin T. Reddy - Minneapolis MN, US Matthew S. Stay - Bloomington MN, US Matthew R.D. Smith - Woodbury MN, US Jennifer J. Post - St. Paul MN, US
A method for making a dental appliance configured to position at least one tooth of a patient includes printing a hardenable liquid resin composition on a major surface of a polymeric material to form a pattern thereon, wherein the hardenable liquid resin composition includes a glass ionomer, a resin modified glass ionomer, and mixtures and combinations thereof. A dental appliance is formed from the polymeric material that includes an arrangement of cavities configured to receive one or more teeth.
- St. Paul MN, US Paul R. Klaiber - Mahtomedi MN, US Richard P. Rusin - Woodbury MN, US Daniel J. Skamser - Ham Lake MN, US Negus B. Adefris - St. Paul MN, US
International Classification:
A61C 7/08 A61C 19/06 A61K 6/69
Abstract:
A dental appliance is described, the dental appliance including a polymeric substrate with a plurality of cavities for receiving one or more teeth, an arrangement of engineered microstructures on the substrate wherein the engineered microstructures include a therapeutic agent. The microstructures may be three-dimensionally engineered on a polymeric film disposed on a major surface of the polymeric substrate, wherein the microstructures extend outwards from the surface. The microstructures also comprise a compound releasable from the three-dimensionally engineered microstructures over a predetermined patient wear time.
A dispenser () for liquids includes a reservoir () defining a volume (V) for housing a liquid (); a delivery tube () with a first end () attached to the reservoir, and a second end () distal from the reservoir, the delivery tube including a passage () in fluid communication with the volume of the reservoir and extending away from the reservoir; an applicator element () including an applicator tip () and a base () attached to the second end of the delivery tube, the applicator tip having a plurality of fingers () extending away from the base to a distal end of the applicator element distal from the delivery tube; and a removable seal (), wherein removal of the removable seal creates an opening in the passage at a location upstream of the applicator tip and a fluid distribution channel between the fingers.
Aqueous Oral Care Fluoride Treatment Compositions, And Methods
- St. Paul MN, US Tiffany T. Ton - Woodbury MN, US Melinda B. Gustafson - Lake Elmo MN, US Jennifer Post - St. Paul MN, US Paul R. Klaiber - Mahtomedi MN, US Carola A. Carrera Vidal - Plymouth MN, US Joel D. Oxman - Minneapolis MN, US
An aqueous oral care fluoride treatment composition, a method of providing fluoride to a patient's tooth surface, and a method of reducing the incidence of dental caries, wherein the composition includes: 0.1 wt-% to 3.0 wt-% of a crosslinked poly acid having carboxylic acid side groups; a pharmaceutically acceptable buffer; 1.0 wt-% to 2.5 wt-% of sodium fluoride; 0.025 wt-% to 1.75 wt-% of a multivalent cation salt; and at least 60 wt-% water; wherein the weight percentages are based on the total weight of the aqueous composition.
3M since Sep 1998
Product Development Chemist - 3M ESPE Dental Products Laboratory
3M Pharmaceuticals 2002 - 2006
Product Development Chemist
Education:
Augsburg College 1987 - 1991
Skills:
Product Development Polymers Design of Experiments Chemistry R&D Materials Science Adhesives Polymer Science Commercialization Coatings Cross Functional Team Leadership Polymer Chemistry Product Management Laboratory Uv/Vis Gmp Medical Devices Classic Rock Research and Development Six Sigma Management Research Leadership Materials Fda Project Management