Paul D May

US Patent:

53408020, Aug 23, 1994

Filed:

Jan 29, 1993

Appl. No.:

8/011055

Inventors:

Kazumi Shiosaki - Libertyville IL
Alex M. Nadzan - San Diego CA
David S. Garvey - Lake Forest IL
Youe-Kong Shue - Vernon Hills IL
Mark S. Brodie - Glenview IL
Mark W. Holladay - Libertyville IL
John Y.-L. Chung - Edison NJ
Michael D. Tufano - Chicago IL
Paul D. May - Richland MI

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3702
C07K 506
C07K 508
C07K 510

US Classification:

514 18

Abstract:

Peptide analog type-B CCK receptor ligands or pharmaceutically-acceptable salts thereof, which are useful for treating central nervous system disorders, substance abuse, gastrointestinal disorders, endocrine disorders, eating-related disorders and for the treatment of shock, respiratory and cardiocirculatory insufficiencies.

US Patent:

51207516, Jun 9, 1992

Filed:

Mar 29, 1991

Appl. No.:

7/677687

Inventors:

James B. Summers - Libertyville IL
Douglas H. Steinman - Morton Grove IL
Denise E. Guinn - Grayslake IL
Steven K. Davidsen - Mundelein IL
Paul D. May - Bristol WI

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D41704
A61K 3144

US Classification:

514342

Abstract:

Benzoylphenyl derivatives of 2-(3-pyridinyl)-3-alkyl-4-thiazolidinecarboxamide, 2-(3-pyridinyl)-thiazolid-4-ylacetamide, 2-(3-pyridinyl)-4-dithiolanecarboxamide or 2-(3-pyridinyl)dithiolan-4-yl] urea are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.

US Patent:

51207494, Jun 9, 1992

Filed:

Feb 20, 1991

Appl. No.:

7/658134

Inventors:

James B. Summers - Libertyville IL
George S. Sheppard - Wilmette IL
James G. Phillips - Antioch IL
Daisy Pireh - Lincolnshire IL
Douglas H. Steinman - Morton Grove IL
Paul D. May - Bristol WI

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D40314
C07D40114
A61K 3140

US Classification:

514337

Abstract:

Indole compounds substituted at the 1- or 3 position by a (pyrid-3 yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl) dithiolan-4-ol)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.

US Patent:

53826701, Jan 17, 1995

Filed:

Jul 7, 1993

Appl. No.:

8/084257

Inventors:

James B. Summers - Libertyville IL
George S. Sheppard - Wilmette IL
James G. Phillips - Antioch IL
Daisy Pireh - Lincolnshire IL
Douglas H. Steinman - Morton Grove IL
Paul D. May - Richland MI
Denise E. Guinn - Grayslake IL
H. Robin Heyman - Chicago IL
George M. Carrera - Des Plaines IL
Steven K. Davidsen - Mundelein IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D21304
C07D20904
C07D27704

US Classification:

546273

Abstract:

Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.