Paul C Murray

US Patent:

6575021, Jun 10, 2003

Filed:

Apr 10, 2002

Appl. No.:

10/120199

Inventors:

Harold J. Kosasky - Chestnut Hill MA
Elias G. Noukas - Milford NH
Paul D. Murray - Carlisle MA
Alfredo O. Kenig - Carlisle MA

Assignee:

Boston Rheology, Inc. - Chestnut Hill MA

International Classification:

A61B 1000

US Classification:

73 5437, 73 5422, 73 5402

Abstract:

A sample surface component for an instrument the measures viscosity and viscoelasticity. The instrument has a cam, a follower arm, a flat spring, a plate fixture, and a removable plate assembly. The cam is a rotating circular disk with a spiral slot. A cam follower on the follower arm resides in the spiral slot so that the follower arm pivots about its fixed end as the cam rotates. The spring is attached to and collinear with the fixed end of the follower arm so that the spring pivots in the opposite direction as the follower arm. The sample surface component include a removable plate assembly with a lower plate and an upper plate with mating sample surfaces on which test fluid is placed. The lower plate fits into a lower jaw of the plate fixture that is attached to the instrument base. The upper plate fits into an upper jaw of the plate fixture attached to the free end of the spring. A fluid is placed on the lower sample surface.

US Patent:

8420380, Apr 16, 2013

Filed:

Apr 8, 2008

Appl. No.:

12/099717

Inventors:

Robert Fishman - Boston MA, US
Robert Havener - Lynnfield MA, US
Ihab Abdel Fattah - Andover MA, US
Anas Abdelazim - North Andover MA, US
Scott Newell - Ipswich MA, US
Tom Bishop - Wenham MA, US
Tamer Khayal - North Andover MA, US
Stanley Kyi - Andover MA, US
Ron Taylor - Chester NH, US
Doug Harriott - Melrose MA, US
Matthew De Remer - Allston MA, US
Paul Murray - Groton MA, US
John Sullivan - Groton MA, US
Mark Anderson - Danvers MA, US
Richard Bringham - North Andover MA, US
Michael Van Driel - Mirandola, IT
Waleed Hassanein - North Andover MA, US

Assignee:

TransMedics, Inc. - Andover MA

International Classification:

A01N 1/02

US Classification:

4352841, 435 12

Abstract:

Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

US Patent:

20090197240, Aug 6, 2009

Filed:

Apr 8, 2008

Appl. No.:

12/099715

Inventors:

Robert Fishman - Boston MA, US
Robert Havener - Lynnfield MA, US
Ihab Abdel Fattah - Andover MA, US
Anas Abdelazim - North Andover MA, US
Scott Newell - Ipswich MA, US
Tom Bishop - Wenham MA, US
Tamer Khayal - North Andover MA, US
Stanley Kyi - Andover MA, US
Ron Taylor - Chester NH, US
Doug Harriott - Melrose MA, US
Matthew De Remer - Allston MA, US
Paul Murray - Groton MA, US
John Sullivan - Groton MA, US
Mark Anderson - Danvers MA, US
Richard Bringham - North Andover MA, US
Michael Van Driel - Mirandola, IT
Waleed Hassanein - , US

Assignee:

TRANSMEDICS, INC - Andover MA

International Classification:

A01N 1/02
A61B 19/00

US Classification:

435 12, 12820024, 128898

Abstract:

Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

US Patent:

20090197292, Aug 6, 2009

Filed:

Apr 8, 2008

Appl. No.:

12/099687

Inventors:

Robert Fishman - Boston MA, US
Robert Havener - Lynnfield MA, US
Ihab Abdel Fattah - Andover MA, US
Anas Abdelazim - North Andover MA, US
Scott Newell - Ipswich MA, US
Tom Bishop - Wenham MA, US
Tamer Khayal - North Andover MA, US
Stanley Kyi - Andover MA, US
Ron Taylor - Chester NH, US
Doug Harriott - Melrose MA, US
Matthew De Remer - Allston MA, US
Paul Murray - Groton MA, US
John Sullivan - Groton MA, US
Mark Anderson - Danvers MA, US
Richard Bringham - North Andover MA, US
Michael Van Driel - Mirandola, IT
Waleed Hassanein - , US

International Classification:

C12Q 1/02
C12M 1/00

US Classification:

435 29, 4352841

Abstract:

Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

US Patent:

20090197324, Aug 6, 2009

Filed:

Apr 8, 2008

Appl. No.:

12/099725

Inventors:

Robert FISHMAN - Boston MA, US
Robert HAVENER - Lynnfield MA, US
Ihab Abdel FATTAH - Andover MA, US
Anas ABDELAZIM - North Andover MA, US
Scott NEWELL - Ipswich MA, US
Tom BISHOP - Wenham MA, US
Tamer KHAYAL - North Andover MA, US
Stanley KYI - Andover MA, US
Ron TAYLOR - Chester NH, US
Doug HARRIOTT - Melrose MA, US
Matthew DE REMER - Allston MA, US
Paul MURRAY - Groton MA, US
John SULLIVAN - Groton MA, US
Mark ANDERSON - Danvers MA, US
Richard BRINGHAM - North Andover MA, US
Michael VAN DRIEL - Mirandola, IT
Waleed Hassanein - , US

International Classification:

A01N 1/02

US Classification:

4352841

Abstract:

Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

US Patent:

20090197325, Aug 6, 2009

Filed:

Apr 8, 2008

Appl. No.:

12/099728

Inventors:

Robert FISHMAN - Boston MA, US
Robert HAVENER - Lynnfield MA, US
Ihab Abdel FATTAH - Andover MA, US
Anas ABDELAZIM - North Andover MA, US
Scott NEWELL - Ipswich MA, US
Tom BISHOP - Wenham MA, US
Tamer KHAYAL - North Andover MA, US
Stanley KYI - Andover MA, US
Ron TAYLOR - Chester NH, US
Doug HARRIOTT - Melrose MA, US
Matthew DE REMER - Allston MA, US
Paul MURRAY - Groton MA, US
John SULLIVAN - Groton MA, US
Mark ANDERSON - Danvers MA, US
Richard BRINGHAM - North Andover MA, US
Michael VAN DRIEL - Mirandola, IT
Waleed Hassanein - , US

International Classification:

A01N 1/02

US Classification:

4352841

Abstract:

Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

US Patent:

20140024931, Jan 23, 2014

Filed:

Jul 20, 2012

Appl. No.:

13/554596

Inventors:

David Winston - Winchester MA, US
Paul Murray - Groton MA, US
Victor Grinberg - Somerville MA, US
Marc Davidson - Andover MA, US

Assignee:

LIGHTLAB IMAGING, INC. - Westford MA

International Classification:

A61B 6/00
A61B 8/12
A61B 6/02
A61B 5/00
A61B 1/07

US Classification:

600427, 600300, 600478, 600467, 600407

Abstract:

In part, the invention relates to systems, methods, and devices that store and retrieve information associated with an imaging probe such as an ultrasound probe, an optical coherence tomography probe, a multimodal probe and other probes. The information that is stored relates to one or more measurable properties for a specific imaging probe. Thus, when each probe is manufactured there can be variations in its length, brightness, angular alignment of its constituent elements, and various other probe specific measurements. In turn, these measurements can be used to calibrate or otherwise use a given probe with a system that collects, stores, or otherwise processes information collected using each probe.