Paul W Myers

US Patent:

20030022279, Jan 30, 2003

Filed:

Jan 12, 2001

Appl. No.:

09/759130

Inventors:

Christopher Fraser - Lexington MA, US
Thomas Barnes - Brookline MA, US
John Sharp - Arlington MA, US
Susan Kirst - Brookline MA, US
Paul Myers - Cambridge MA, US
Kevin Leiby - Natick MA, US
Douglas Holtzman - Jamaica Plain MA, US
Sean McCarthy - San Diego CA, US
Nicholas Wrighton - Winchester MA, US
Charles MacKay - Vaucluse, AU
Andrew Goodearl - Natick MA, US

International Classification:

A01K067/00
C07H021/04
C12P021/02
C12N005/06
C07K014/435

US Classification:

435/069100, 435/320100, 435/325000, 514/044000, 530/350000, 536/023200, 800/008000

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20040121396, Jun 24, 2004

Filed:

Dec 19, 2003

Appl. No.:

10/741790

Inventors:

Christopher Fraser - Lexington MA, US
Thomas Barnes - Brookline MA, US
John Sharp - Arlington MA, US
Susan Kirst - Brookline MA, US
Paul Myers - Cambridge MA, US
Kevin Leiby - Natick MA, US
Douglas Holtzman - Jamaica Plain MA, US
Sean McCarthy - San Diego CA, US
Nicholas Wrighton - Winchester MA, US
Charles MacKay - Vaucluse, AU
Andrew Goodearl - Natick MA, US

Assignee:

Millennium Pharmaceuticals, Inc.

International Classification:

C12Q001/68
A01K067/00
C07H021/04
C07K014/47

US Classification:

435/006000, 435/069100, 435/320100, 435/325000, 530/350000, 536/023200, 800/008000, 530/388100

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20100062487, Mar 11, 2010

Filed:

May 8, 2009

Appl. No.:

12/387959

Inventors:

Christopher C. Fraser - Lexington MA, US
Thomas M. Barnes - Brookline MA, US
John D. Sharp - Arlington MA, US
Susan J. Kirst - Brookline MA, US
Paul S. Myers - Cambridge MA, US
Kevin R. Leiby - Natick MA, US
Douglas A. Holtzman - Jamaica Plain MA, US
Sean A. McCarthy - San Diego CA, US
Nicholas Wrighton - Winchester MA, US
Charles R. Mackay - Vaucluse, AU
Andrew D.J. Goodearl - Natick MA, US

International Classification:

C12P 21/02
C07H 21/04
C12N 5/00
C12N 1/00
C07K 14/00
C07K 16/00
G01N 33/53

US Classification:

435 691, 536 231, 435325, 435243, 530350, 5303871, 436 86, 436 94, 536 243

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20120045777, Feb 23, 2012

Filed:

Jun 27, 2011

Appl. No.:

13/169686

Inventors:

Christopher C. Fraser - Lexington MA, US
Thomas M. Barnes - Brookline MA, US
John D. Sharp - Arlington MA, US
Susan J. Kirst - Brookline MA, US
Paul S. Myers - Cambridge MA, US
Kevin R. Leiby - Natick MA, US
Douglas A. Holtzman - Jamaica Plain MA, US
Sean A. McCarthy - San Diego CA, US
Nicholas Wrighton - Winchester MA, US
Charles R. Mackay - Vaucluse, AU
Andrew D.J. Goodearl - Natick MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 33/53
C12Q 1/37
C12P 21/02
C12N 9/99
C12N 9/64
C12N 15/57
C12N 5/00
C12N 15/63
G01N 33/50
C07K 14/00
C07K 16/18
C07H 21/04
G01N 33/573
C12N 5/10

US Classification:

435 721, 435 74, 435 792, 435 23, 435 691, 435184, 435226, 435325, 435375, 4353201, 436501, 436 94, 530350, 5303879, 536 231, 536 232

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20140072968, Mar 13, 2014

Filed:

Apr 10, 2013

Appl. No.:

13/860048

Inventors:

John D. Sharp - Arlington MA, US
Kevin R. Leiby - San Francisco CA, US
Steven Bossone - Winchester MA, US
Yang Pan - Bellevue WA, US
Thomas M. Barnes - Boston MA, US
Christopher C. Fraser - Arlington MA, US
Nicholas Wrighton - Winchester MA, US
Paul S. Myers - Jamaica Plain MA, US
Gillian Kingsbury - Wayland MA, US

Assignee:

Dana-Farber Cancer Institute, Inc. - Boston MA

International Classification:

C07K 14/705

US Classification:

435 611, 536 235, 4353201, 435325, 530350, 5303879, 435 691, 435 721, 435375

Abstract:

The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

20210342735, Nov 4, 2021

Filed:

Apr 30, 2020

Appl. No.:

16/863460

Inventors:

- Armonk NY, US
- Cambridge MA, US
Kenney Ng - Arlington MA, US
Paul D. Myers - Bloomfield Hills MI, US
Collin M. Stultz - Newton MA, US

International Classification:

G06N 20/00
G06N 5/02

Abstract:

A computer system trains a predictive model. A plurality of subsets of features are selected from a dataset comprising a plurality of cases and controls and a plurality of features. Cases and controls are matched to select a plurality of case-control subsets for each subset of features, each case-control subset having similar values for the corresponding subset of features. For each case-control subset, a statistical significance of each feature of the plurality of features absent from the subset of features used to match the case-control subset is identified. A final subset of features is selected based on satisfying a statistical significance of each feature for the plurality of case-control subsets. A predictive model is trained using the final subset of features. Embodiments of the present invention further include a method and program product for training a predictive model in substantially the same manner described above.

US Patent:

20210343421, Nov 4, 2021

Filed:

Apr 30, 2020

Appl. No.:

16/863452

Inventors:

- Armonk NY, US
- Cambridge MA, US
Kenney Ng - Arlington MA, US
Paul D. Myers - Bloomfield Hills MI, US
Collin M. Stultz - Newton MA, US

International Classification:

G16H 50/50
G16H 50/70
G06K 9/62
G06F 17/18

Abstract:

A computer system selects features of a dataset for predictive modeling. A first set of features that are relevant to outcome are selected from a dataset comprising a plurality of cases and controls. A subset of cases and controls having similar values for the first set of features is identified. The subset is analyzed to select a set of additional features relevant to outcome. A first and second predictive model are evaluated to determine that the second predictive model more accurately predicts outcome, wherein the first predictive model is based on the first set of features and the second predictive model is based on the first set of features and the additional features. The second predictive model is utilized to predict outcomes. Embodiments of the present invention further include a method and program product for selecting features of a dataset for predictive modeling in substantially the same manner described above.