Paul N Porensky

US Patent:

20210100918, Apr 8, 2021

Filed:

Nov 23, 2020

Appl. No.:

17/102291

Inventors:

- Columbus OH, US
Paul Porensky - Columbus OH, US

International Classification:

A61K 48/00
C12N 15/86
A61K 38/17
A61K 49/04
C07K 14/47

Abstract:

The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as SMA and ALS as well as Pompe disease and lysosomal storage disorders.

US Patent:

20190269798, Sep 5, 2019

Filed:

May 8, 2019

Appl. No.:

16/406904

Inventors:

- Columbus OH, US
Paul Porensky - Columbus OH, US

International Classification:

A61K 48/00
C07K 14/47
A61K 38/17
A61K 49/04
C12N 15/86

Abstract:

The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as SMA and ALS as well as Pompe disease and lysosomal storage disorders. It is disclosed that administration of a non-ionic, low-osmolar contrast agent, together with a rAAV9 vector for the expression of Survival Motor Neuron protein, improves the survival of SMN mutant mice as compared to the administration of the expression vector alone.

US Patent:

20190151477, May 23, 2019

Filed:

Jun 4, 2018

Appl. No.:

15/997433

Inventors:

- Columbus OH, US
Paul Porensky - Columbus OH, US

International Classification:

A61K 48/00
C07K 14/47
A61K 38/17
A61K 49/04
C12N 15/86

Abstract:

The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as SMA and ALS as well as Pompe disease and lysosomal storage disorders. It is disclosed that administration of a non-ionic, low-os-molar contrast agent, together with a rAA9 vector for the expression of Survival Motor Neuron protein, improves the survival of SMN mutant mice as compared to the administration of the expression vector alone.

US Patent:

20190099503, Apr 4, 2019

Filed:

Sep 12, 2018

Appl. No.:

16/129096

Inventors:

- Columbus OH, US
Paul Porensky - Columbus OH, US

International Classification:

A61K 48/00
C12N 15/86
A61K 38/17
C07K 14/47
A61K 49/04

Abstract:

The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as SMA and ALS as well as Pompe disease and lysosomal storage disorders. It is disclosed that administration of a non-ionic, low-osmolar contrast agent, together with a rAA9 vector for the expression of Survival Motor Neuron protein, improves the survival of SMN mutant mice as compared to the administration of the expression vector alone.

US Patent:

20170216458, Aug 3, 2017

Filed:

Apr 14, 2017

Appl. No.:

15/488203

Inventors:

- Columbus OH, US
Paul Porensky - Columbus OH, US

International Classification:

A61K 48/00
C12N 15/86
C07K 14/47
A61K 49/04
A61K 38/17

Abstract:

The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as SMA and ALS as well as Pompe disease and lysosomal storage disorders. It is disclosed that administration of a non-ionic, low-osmolar contrast agent, together with a rAA9 vector for the expression of Survival Motor Neuron protein, improves the survival of SMN mutant mice as compared to the administration of the expression vector alone.

US Patent:

20150252384, Sep 10, 2015

Filed:

Jul 31, 2013

Appl. No.:

14/417823

Inventors:

- Columbus OH, US
Paul Porensky - Columbus OH, US

International Classification:

C12N 15/86

Abstract:

The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as SMA and ALS as well as Pompe disease and lysosomal storage disorders. It is disclosed that administration of a non-ionic, low-osmolar contrast agent, together with a rAA9 vector for the expression of Survival Motor Neuron protein, improves the survival of SMN mutant mice as compared to the administration of the expression vector alone.

Address:

122 W Stanton Ave, Worthington, OH 43085

VIN:

KMHDU46D87U101146

Make:

HYUNDAI

Model:

ELANTRA

Year:

2007