Paul B Reid

US Patent:

20210219551, Jul 22, 2021

Filed:

Jul 31, 2020

Appl. No.:

16/945369

Inventors:

- Nashville TN, US
Gregory M. Pask - Nashville TN, US
David C. Rinker - Nashville TN, US
Ian M. Romaine - Goodlettsville TN, US
Gary A. Sulikowski - Brentwood TN, US
Paul R. Reid - Durham NC, US
Alex G. Waterson - Murfreesboro TN, US
Kwangho Kim - Nashville TN, US
Patrick L. Jones - Danvers MA, US
Robert W. Taylor - Nashville TN, US

International Classification:

A01N 43/653
A01N 43/82
A01N 43/78
A01N 43/90
A01N 25/08
A01N 47/16
A01N 47/18
A01N 53/00
C07D 249/12
C07D 401/04
C07D 401/14
C07D 403/04
C07D 405/04
C07D 405/06
C07D 405/14
C07D 409/04
C07D 409/14
C07D 413/14
C07D 471/04
C07D 491/048
C07D 491/052
C07D 491/056
C07D 513/04

Abstract:

In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitos. Methods of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

US Patent:

20190075798, Mar 14, 2019

Filed:

Nov 9, 2018

Appl. No.:

16/186106

Inventors:

- Nashville TN, US
Gregory M. Pask - Nashville TN, US
David C. Rinker - Nashville TN, US
Ian M. Romaine - Goodlettsville TN, US
Gary A. Sulikowski - Brentwood TN, US
Paul R. Reid - Durham NC, US
Alex G. Waterson - Murfreesboro TN, US
Kwangho Kim - Nashville TN, US
Patrick L. Jones - Danvers MA, US
Robert W. Taylor - Nashville TN, US

International Classification:

A01N 43/653
C07D 491/048
C07D 491/056
A01N 25/08
A01N 47/16
A01N 47/18
A01N 53/00
C07D 249/12
C07D 401/04
C07D 401/14
C07D 403/04
C07D 405/04
C07D 405/06
C07D 405/14
C07D 409/04
C07D 409/14
C07D 413/14
C07D 471/04
C07D 513/04
C07D 491/052
A01N 43/82
A01N 43/90
A01N 43/78
A01N 25/34
A01N 27/00
A01N 29/02
A01N 33/18
A01N 33/22
A01N 47/08
A01N 47/14
A01N 57/12
A01N 57/14
A01N 57/16

Abstract:

In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitoes. Methods of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

US Patent:

20170246149, Aug 31, 2017

Filed:

Apr 21, 2017

Appl. No.:

15/494148

Inventors:

- Nashville TN, US
Laura Anzaldi Mike - Nashville TN, US
Gary Sulikowski - Brentwood TN, US
Alex Waterson - Murfreesboro TN, US
Paul Reid - Nashville TN, US

International Classification:

A61K 31/415
C12Q 1/18
A61K 31/4155
A61K 45/06
A61K 31/7008

Abstract:

Embodiments of the presently-disclosed subject matter include activators of HssRS that induce endogenous heme biosynthesis by perturbing central metabolism. These molecules are toxic to fermenting including clinically relevant small colony variants (SCVs). The utility of targeting fermenting bacteria is exemplified by the fact that this compound prevents the emergence of antibiotic resistance, enhances phagocyte killing, and reduces pathogenesis. This small molecule is a powerful tool not only for studying bacterial heme biosynthesis and central metabolism, but also establishes targeting of fermentation as a viable antibacterial strategy.

US Patent:

20170208809, Jul 27, 2017

Filed:

Feb 27, 2017

Appl. No.:

15/443340

Inventors:

- Nashville TN, US
Gregory M. Pask - Nashville TN, US
David C. Rinker - Nashville TN, US
Ian M. Romaine - Goodlettsville TN, US
Gary A. Sulikowski - Brentwood TN, US
Paul R. Reid - Durham NC, US
Alex G. Waterson - Murfreesboro TN, US
Kwangho Kim - Nashville TN, US
Patrick L. Jones - Danvers MA, US
Robert W. Taylor - Nashville TN, US

International Classification:

A01N 43/653
C07D 401/04
A01N 53/00
C07D 471/04
A01N 43/90
C07D 405/14
C07D 401/14
C07D 491/056
C07D 491/052
A01N 47/18
C07D 491/048
C07D 409/04
A01N 47/16
C07D 409/14
C07D 405/04
C07D 249/12
C07D 405/06
C07D 403/04
C07D 413/14
C07D 513/04
A01N 25/08

Abstract:

In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitoes. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

US Patent:

20160243063, Aug 25, 2016

Filed:

Aug 18, 2015

Appl. No.:

14/829453

Inventors:

- Nashville TN, US
Paul R. Reid - Nashville TN, US

International Classification:

A61K 31/16
A61K 31/4745
A61K 31/704
A61K 31/198
A61K 31/513
A61K 33/24

Abstract:

A method of treating cancer in a subject in need thereof, comprising administering to the subject a first amount of a compound of the HAT inhibitor of the following formula:wherein R is chosen from coenzyme A, (CH)NHCO(CH)NHCOR; (CH)NHCOR; (CH)NHCO(CH)NHCOR; Ris H, NH, NH, N, and Rcan optionally cyclize with at least one other Xto form a Cmembered ring containing C, O, S, or N; Ris chosen from alkyl, cycloalkyl, aryl, heteroaryl; Ris chosen from an alkyl, cycloalkyl, aryl, heteroaryl; Ris chosen from CH(OH)C(CH)CH)OCOR; Xis chosen from H or can cyclize with one other Xor Rto form a Cmembered ring containing C, O, S, or N; and Xis chosen from C, N, NH, and can optionally cyclize with at least one other Xor Rto form a Cmembered ring containing C, O, S, or N; or a pharmaceutically acceptable salt or hydrate thereof, thereby treating the cancer.

US Patent:

20160213780, Jul 28, 2016

Filed:

Jan 22, 2016

Appl. No.:

15/004141

Inventors:

- Nashville TN, US
Matthew Surdel - Nashville TN, US
Gary A. Sulikowski - Brentwood TN, US
Brendan Dutter - Nashville TN, US
Paul Reid - Durham NC, US
Alex Waterson - Murfreesboro TN, US

International Classification:

A61K 41/00
C12Q 1/18
A61N 5/06
C07D 405/04
C07D 409/04
C07D 231/12
C12N 9/02
C12Q 1/68

Abstract:

A method for treating a microbial infection involves administering an effective amount of a compound of the formula:wherein Ris H, alkyl, aryl, heteroaryl, Ris H, halogen, alkyl, aryl, heteroaryl, Ris H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, Ris H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, Ris H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, Ris H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, Ris H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, Ris —CR, O, S, wherein Rand R, Rand R, Rand R, Rand Rcan cyclize forming a 3-10 member ring comprising C, O, S, and/or N optionally substituted with one or more R; and administering light therapy, such as a photodynamic therapy (PDT) light source.

US Patent:

20150174130, Jun 25, 2015

Filed:

Jul 26, 2013

Appl. No.:

14/417277

Inventors:

- Nashville TN, US
Laura Anzaldi - Nashville TN, US
Gary Sulikowski - Brentwood TN, US
Alex Waterson - Murfreesboro TN, US
Paul Reid - Nashville TN, US

International Classification:

A61K 31/519
A61K 31/415
A61K 31/4439
A61K 45/06
C12Q 1/18
C07D 487/04
C07D 401/04
C07D 409/04
C07D 231/12
A61K 31/4155
C07D 405/04

Abstract:

Embodiments of the presently-disclosed subject matter include activators of HssRS that induce endogenous heme biosynthesis by perturbing central metabolism. These molecules are toxic to fermenting , including clinically relevant small colony variants (SCVs). The utility of targeting fermenting bacteria is exemplified by the fact that this compound prevents the emergence of antibiotic resistance, enhances phagocyte killing, and reduces pathogenesis. This small molecule is a powerful tool not only for studying bacterial heme biosynthesis and central metabolism, but also establishes targeting of fermentation as a viable antibacterial strategy.

US Patent:

20140242135, Aug 28, 2014

Filed:

Apr 25, 2012

Appl. No.:

14/115553

Inventors:

Laurence Zwiebel - Nashville TN, US
Gregory M. Pask - Nashville TN, US
David C. Rinker - Nashville TN, US
Ian M. Romaine - Nashville TN, US
Gary A. Sulikowski - Brentwood TN, US
Paul R. Reid - Durham NC, US
Alex G. Waterson - Murfreesboro TN, US
Kwangho Kim - Nashville TN, US
Patrick L. Jones - Danvers MA, US
Robert W. Taylor - Chicago IL, US

Assignee:

Vanderbilt University - Nashville TN

International Classification:

A01N 43/653
A01N 43/78
A01N 43/90

US Classification:

424403, 514340, 5462724, 424405, 514299, 546112, 514300, 546122, 514314, 546171, 514338, 514337, 514339, 514302, 546115, 514249, 544350, 514384, 5482644, 514365, 548205

Abstract:

In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitos. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.