Paul A Roethle from 2210 Browning St, Berkeley, CA 94702, age 44, Phone: 4155996200

Us Patents

Dihydropyrido[4,3-B]Pyrazine-3-Ones As Modulators Of Toll-Like Receptors
view source
US Patent:

8476270, Jul 2, 2013
Filed:

Sep 10, 2010
Appl. No.:

12/879697
Inventors:

Randall L. Halcomb - Foster City CA, US
Paul A. Roethle - San Francisco CA, US
Assignee:

Gilead Sciences, Inc. - Foster City CA
International Classification:

A61K 31/495
US Classification:

514249, 544350, 548518
Abstract:

The present invention relates to novel dihydropyrido[4,3 -b]pyrazin-3(4H)-ones of the general formula:.

Modulators Of Toll-Like Receptors
view source
US Patent:

8507507, Aug 13, 2013
Filed:

Oct 15, 2010
Appl. No.:

12/905268
Inventors:

Randall L. Halcomb - Foster City CA, US
Paul A. Roethle - San Francisco CA, US
Assignee:

Gilead Sciences, Inc. - Foster City CA
International Classification:

A61K 31/522
C07D 473/00
US Classification:

51426337, 544276
Abstract:

The present application includes novel modulators of TLRs, compositions containing such compounds, therapeutic methods that include the administration of such compounds.

Modulators Of Toll-Like Receptors
view source
US Patent:

8629142, Jan 14, 2014
Filed:

Nov 16, 2012
Appl. No.:

13/679803
Inventors:

Randall L. Halcomb - Foster City CA, US
Paul Hrvatin - South San Francisco CA, US
Hon Chung Hui - San Mateo CA, US
Ryan McFadden - Foster City CA, US
Paul A. Roethle - San Francisco CA, US
Hong Yang - Fremont CA, US
Assignee:

Gilead Sciences, Inc. - Foster City CA
International Classification:

C07D 475/06
C07D 475/08
C07D 475/12
C07D 487/04
A61K 31/519
A61P 31/12
A61P 35/00
US Classification:

514249, 544258, 544259
Abstract:

Provided are modulators of TLRs of Formula II:.

Modulators Of Toll-Like Receptors
view source
US Patent:

20100143301, Jun 10, 2010
Filed:

Dec 7, 2009
Appl. No.:

12/632194
Inventors:

Manoj C. Desai - Pleasant Hill CA, US
Randall L. Halcomb - Foster City CA, US
Paul Hrvatin - South San Francisco CA, US
Hon Chung Hui - San Mateo CA, US
Ryan Mc Fadden - Foster City CA, US
Paul A. Roethle - San Francisco CA, US
Hong Yang - Fremont CA, US
Assignee:

Gilead Sciences, Inc. - Foster City CA
International Classification:

A61K 31/519
C07D 475/06
C07D 487/04
A61K 31/5377
A61K 31/551
A61K 38/21
A61K 31/7056
A61K 31/675
A61K 31/56
A61P 31/12
US Classification:

424 857, 544258, 540502, 544118, 514249, 51421021, 5142342, 514221, 424 854, 514 43, 514 81, 514171
Abstract:

Provided are modulators of TLRs of Formula II:pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Therapeutic Compounds
view source
US Patent:

20130281433, Oct 24, 2013
Filed:

Apr 19, 2013
Appl. No.:

13/866997
Inventors:

Gediminas Brizgys - San Mateo CA, US
Jake Cha - Burlingame CA, US
Xiaowu Chen - Hillsborough CA, US
Hongyan Guo - San Mateo CA, US
Randall L. Halcomb - Foster City CA, US
Xiaochun Han - San Mateo CA, US
Richard Huang - San Mateo CA, US
Hongtao Liu - Cupertino CA, US
Ryan McFadden - Foster City CA, US
Michael L. Mitchell - Hayward CA, US
Yingmei Qi - Sunnyvale CA, US
Paul A. Roethle - San Francisco CA, US
Lianhong Xu - Palo Alto CA, US
Hong Yang - Fremont CA, US
International Classification:

C07D 417/14
A61K 31/4439
A61K 31/444
A61K 31/506
A61K 31/496
A61K 31/428
C07D 471/04
A61K 31/437
A61K 31/513
A61K 31/497
A61K 31/5377
A61K 31/454
C07D 498/04
A61K 31/5383
A61K 31/4375
A61K 31/4709
A61K 31/501
C07D 487/04
A61K 31/4985
A61K 31/553
A61K 31/551
A61K 45/06
C07D 417/10
US Classification:

51421021, 5462701, 514338, 546256, 514333, 544333, 514256, 544364, 5142531, 548180, 514367, 546119, 514303, 546113, 514300, 544318, 514274, 544405, 51425505, 544122, 5142338, 544295, 51425218, 544331, 514272, 546198, 514321, 544105, 5142305, 546122, 546157, 514312, 546159, 514313, 544238, 51425206, 544131, 544350, 514249, 544357, 51425211, 540490, 51421105, 540575, 514218
Abstract:

Compounds disclosed herein including compounds of formula I′:and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.

Therapeutic Compounds
view source
US Patent:

20130281434, Oct 24, 2013
Filed:

Apr 19, 2013
Appl. No.:

13/867016
Inventors:

Gediminas Brizgys - San Mateo CA, US
Hongtao Liu - Cupertino CA, US
Ryan McFadden - Foster City CA, US
Michael L. Mitchell - Hayward CA, US
Yingmei Qi - Sunnyvale CA, US
Paul A. Roethle - San Francisco CA, US
Lianhong Xu - Palo Alto CA, US
Hong Yang - Fremont CA, US
Assignee:

Gilead Sciences, Inc. - Foster City CA
International Classification:

C07D 491/06
C07D 277/82
A61K 31/428
C07D 417/10
A61K 31/5377
C07D 417/14
A61K 31/444
A61K 31/506
A61K 31/496
A61K 31/4741
A61K 31/4439
US Classification:

51421021, 546 89, 514291, 548164, 514367, 5462701, 514338, 546256, 514333, 544333, 514256, 544364, 5142531, 544122, 5142338
Abstract:

Compounds of formula I′:or salts thereof are provided. Pharmaceutical compositions comprising a compound of formula I′, processes for preparing compounds of formula I′, intermediates useful for preparing compounds of formula I′ and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal are also provided.

Benzothiazole Compounds And Their Pharmaceutical Use
view source
US Patent:

20140045818, Feb 13, 2014
Filed:

Apr 20, 2012
Appl. No.:

14/112473
Inventors:

Michael L. Mitchell - Hayward CA, US
Paul A. Roethle - San Francisco CA, US
Lianhong Xu - Palo Alto CA, US
Hong Yang - Fremont CA, US
Ryan McFadden - Foster City CA, US
Kerim Babaoglu - Landsdale PA, US
Assignee:

Gilead Sciences, Inc. - Foster City CA
International Classification:

C07D 491/052
A61K 45/06
C07D 277/82
A61K 31/4741
C07D 277/64
A61K 31/428
US Classification:

51421021, 548180, 514367, 548161, 546 89, 514291
Abstract:

The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula I.

Modulators Of Toll-Like Receptors
view source
US Patent:

20140081022, Mar 20, 2014
Filed:

Nov 25, 2013
Appl. No.:

14/089633
Inventors:

Randall L. Halcomb - Foster City CA, US
Paul Hrvatin - South San Francisco CA, US
Hon Chung Hui - San Mateo CA, US
Ryan McFadden - Foster City CA, US
Paul A. Roethle - San Francisco CA, US
Hong Yang - Fremont CA, US
International Classification:

C07D 475/06
US Classification:

544258
Abstract:

Provided are modulators of TLRs of Formula II:pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.