Paul W Sutton

US Patent:

6210582, Apr 3, 2001

Filed:

Jun 10, 1999

Appl. No.:

9/329538

Inventors:

Michael Arthur Del Vecchio - Flemington NJ
Robert Eben Loudon - Howell NJ
Paul Matthew Sutton - Danbury CT

Assignee:

Envirogen, Inc. - Lawrenceville NJ

International Classification:

B01D 6502

US Classification:

210636

Abstract:

A system is provided for withdrawing permeate from a substrate through a filter and for cleaning the filter in situ. The system includes a vessel configured to contain a substrate and a compartment connected to receive substrate from the vessel and connected to return a portion of received substrate to the vessel during normal operation of the system. The system also includes a filter positioned at least partially within the compartment to withdraw permeate from substrate in the compartment during normal operation of the system. A source of cleaning solution is connected to the compartment to deliver cleaning solution into the compartment and into contact with the filter during cleaning operation of the system. The compartment facilitates circulation of substrate in the vessel during normal operation of the system and substantially prevents introduction of cleaning solution from the compartment into contact with substrate contained in the vessel during cleaning operation. A method is also provided.

US Patent:

6627082, Sep 30, 2003

Filed:

Aug 24, 2001

Appl. No.:

09/939085

Inventors:

Michael Arthur Del Vecchio - Flemington NJ
Robert Eben Loudon - Howell NJ
Paul Matthew Sutton - Enfield NH

Assignee:

Envirogen, Inc. - Lawrenceville NJ

International Classification:

B01D 6502

US Classification:

210636, 2101952, 210332, 21032169, 210617, 210797

Abstract:

A system is provided for withdrawing permeate from a substrate. The exemplary system includes a vessel configured to contain substrate, two or more compartments configured to receive substrate from the vessel and to return a portion of received substrate to the vessel, and a filter positioned at least partially within each of the compartments and configured to separate permeate from substrate during operation of the filter. At least one of the compartments is configured to contain cleaning solution and substantially prevent cleaning solution from contacting substrate in the vessel during cleaning of the filter. The exemplary system is configured for cleaning the filter in situ in at least one of the compartments while operating the filter in at least one other of the compartments. A method for adapting a filtration system for cleaning thereof and a method for withdrawing permeate from a substrate using a filtration system are also provided.

US Patent:

6878282, Apr 12, 2005

Filed:

Sep 29, 2003

Appl. No.:

10/674163

Inventors:

Michael Arthur Del Vecchio - Flemington NJ, US
Robert Eben Loudon - Howell NJ, US
Paul Matthew Sutton - Enfield NH, US

Assignee:

Envirogen, Inc. - Lawrenceville NJ

International Classification:

B01D065/02

US Classification:

210636, 2101952, 2102572, 21032169, 210805

Abstract:

A system is provided for withdrawing permeate from a substrate. The exemplary system includes a vessel having a wall configured to contain substrate, a compartment positioned adjacent the wall of the vessel and configured to receive substrate from the vessel, and a filter positioned at least partially within the compartment and configured to separate permeate from substrate during operation of the filter. The compartment is configured to contain cleaning solution and substantially prevent cleaning solution from contacting substrate in the vessel during cleaning of the filter.

US Patent:

7247746, Jul 24, 2007

Filed:

Apr 14, 2003

Appl. No.:

10/510927

Inventors:

Paul Allen Sutton - Parsippany NJ, US

Assignee:

Novartis, AG - Basel

International Classification:

C07C 229/46
C07C 235/82

US Classification:

562450, 562444, 562445

Abstract:

New crystal forms of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine, also known asnateglinide, may be produced by dissolving nateglinide in any of its forms, including solvates, in an organic solvent to form a solution followed by precipitation of nateglinide from the solution, and isolating and drying the precipitated crystal form of nateglinide. The precipitation of nateglinide may be induced either by cooling the solution, or by addition of another solvent which is miscible with the first solvent but in which nateglinide is only poorly soluble, or by combination of the two. Depending on the solvent a specific crystal form of nateglinide may be obtained, e. g. , the R′-type crystal form of nateglinide produced by the described method has a different melting point, infra red spectra and X-ray diffraction patterns from the previously known crystal forms of nateglinide.

US Patent:

8163904, Apr 24, 2012

Filed:

Jul 18, 2006

Appl. No.:

11/995898

Inventors:

Paul W Manley - Arlesheim, CH
Wen-Chung Shieh - Berkeley Heights NJ, US
Paul Allen Sutton - Parsippany NJ, US
Piotr H Karpinski - Lincoln Park NJ, US
Raeann Wu - Pine Brook NJ, US
Stéphanie Monnier - Raedersheim, FR
Jörg Brozio - Basel, CH

Assignee:

Novartis AG - Basel
Novartis Pharma GmbH - Vienna

International Classification:

C07D 401/14
A61K 31/506
A61P 35/00

US Classification:

544331, 514275

Abstract:

Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes.

US Patent:

8343984, Jan 1, 2013

Filed:

Jul 18, 2006

Appl. No.:

11/995906

Inventors:

Paul W Manley - Arlesheim, CH
Wen-Chung Shieh - Berkeley Heights NJ, US
Paul Allen Sutton - Parsippany NJ, US
Piotr “Peter” H Karpinski - Lincoln Park NJ, US
Raeann Wu - Pine Brook NJ, US
Stéphanie M. Monnier - Raedersheim, FR
Jörg Brozio - Basel, CH

Assignee:

Novartis AG - Basel
Novartis Pharma GmbH - Vienna

International Classification:

A01N 43/54
A61K 31/505
C07D 239/02

US Classification:

514269, 544316

Abstract:

Polymorphic forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base and salts thereof are prepared by various processes.

US Patent:

8389537, Mar 5, 2013

Filed:

Mar 13, 2012

Appl. No.:

13/419132

Inventors:

Paul W Manley - Arlesheim, CH
Wen-Chung Shieh - Berkeley Heights NJ, US
Paul Allen Sutton - Parsippany NJ, US
Piotr H Karpinski - Lincoln Park NJ, US
Raeann Wu - Pine Brook NJ, US
Stéphanie Monnier - Raedersheim, FR
Jörg Brozio - Basel, CH

Assignee:

Novartis AG - Basel

International Classification:

A61K 31/506
A61P 35/00
C07D 401/14

US Classification:

514275, 544331

Abstract:

Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes.

US Patent:

8415363, Apr 9, 2013

Filed:

Aug 3, 2012

Appl. No.:

13/565913

Inventors:

Paul W Manley - Arlesheim, CH
Wen-Chung Shieh - Berkeley Heights NJ, US
Paul Allen Sutton - Parsippany NJ, US
Piotr “Peter” H Karpinski - Lincoln Park NJ, US
Raeann R Wu - Pine Brook NJ, US
Stéphanie M Monnier - Raedersheim, FR
Jörg Brozio - Basel, CH

Assignee:

Novartis AG - Basel

International Classification:

A01N 43/54
A61K 31/505
C07D 239/02

US Classification:

514269, 544316

Abstract:

Crystalline forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base and salts thereof are prepared by various processes.