Peter Kushner - San Francisco CA, US Paul Webb - San Francisco CA, US Renee Williard - San Francisco CA, US C. Anthony Hunt - San Francisco CA, US Gabriella Lopez - San Francisco CA, US
Assignee:
The Regents of the University of California - Oakland CA
The present invention provides novel assay methods for identifying compounds that may have both estrogen agonist and antagonist properties. In particular, the assay use cells comprising promoters having an AP1 site linked to a reporter gene. Compounds capable of inducing or blocking expression of the reporter gene can thus be identified. The compounds may be further tested for the ability to modulate the standard estrogen response, as well.
Method For Creating Specific, High Affinity Nuclear Receptor Pharmaceuticals
John D. Baxter - San Francisco CA, US Thomas S. Scanlan - San Francisco CA, US Robert J. Fetterick - Hillsborough CA, US Sabine Borngraeber - San Francisco CA, US Paul Webb - San Francisco CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
G01N 33/53 G06G 7/48
US Classification:
702 19, 702 20, 703 11, 707102, 435 71
Abstract:
This invention pertains to agonists that activate nuclear receptors. These agonists include an extension that contacts a region of the nuclear receptor outside the native ligand binding pocket. Methods for producing, identifying and designing such agonists are included along with nuclear receptor agonist complexes and libraries of agonists.
Methods For Screening Nuclear Transcription Factors For The Ability To Modulate An Estrogen Response
PETER J. KUSHNER - SAN FRANCISCO CA, US ROSALIE M. UHT - SAN FRANCISCO CA, US PAUL WEBB - SAN FRANCISCO CA, US
International Classification:
C12Q001/68 C12Q001/02 C12N001/00 G01N033/53
US Classification:
435/006000, 435/810000, 435/975000
Abstract:
This invention provides methods of screening a nuclear transcription factor ligand for the ability to modulate estrogen activation at an AP-1 site. The methods involve the steps of: a) providing a first cell containing an estrogen receptor, a receptor for the nuclear transcription factor ligand, and a promoter comprising an AP1 site which regulates expression of a first reporter gene; b) contacting the first cell with the transcription factor ligand and with a compound having AP1 mediated estrogenic activity; and c) detecting expression of the first reporter gene
Compositions Comprising Inhibitors Of Estrogen Response
Peter Kushner - San Francisco CA Paul Webb - San Francisco CA Renee Williard - San Francisco CA C. Anthony Hunt - San Francisco CA Gabriella Lopez - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 3100 A61K 3155 A61K 3135
US Classification:
514 1
Abstract:
The present invention provides novel assay methods for identifying compounds that may have both estrogen agonist and antagonist properties. In particular, the assay use cells comprising promoters having an AP1 site linked to a reporter gene. Compounds capable of inducing or blocking expression of the reporter gene can thus be identified. The compounds may be further tested for the ability to modulate the standard estrogen response, as well.
Methods For Screening Compounds For Estrogenic Activity
Peter Kushner - San Francisco CA Paul Webb - San Francisco CA Renee Williard - San Francisco CA C. Anthony Hunt - San Francisco CA Gabriella Lopez - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
G01N 3368 G01N 3374 C12Q 102 C12N 1500
US Classification:
435 6
Abstract:
The present invention provides novel assay methods for identifying compounds that may have both estrogen agonist and antagonist properties. In particular, the assay use cells comprising promoters having an AP1 site linked to a reporter gene. Compounds capable of inducing or blocking expression of the reporter gene can thus be identified. The compounds may be further tested for the ability to modulate the standard estrogen response, as well.
Methods To Screen For Transcription Factor-Coactivator Interactions
Peter J. Kushner - San Francisco CA Paul Webb - San Francisco CA Rosalie M. Uht - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C12Q 168 C12Q 102
US Classification:
435 6
Abstract:
This invention provides methods for modulating gene expression at the transcriptional level. In particular, the methods involve tethering a transcriptional coactivator to a DNA binding domain that is specific for a target nucleic acid sequence and contacting the coactivator with a transcription factor. The transcription factor triggers or represses transcription mediated by the coactivator. Methods for identifying compounds that are able to modulate gene expression are also provided.
Dr. Webb III graduated from the University of Vermont COM in 1983. He works in Wyalusing, PA and specializes in Internal Medicine. Dr. Webb III is affiliated with Robert Packer Hospital.
Artistry In Concrete Shingle Springs, CA Oct 2009 to Mar 2013 customer serviceLongs Drugs, Macy's,J.C. Penney's, Home Depot San Francisco, CA Oct 2009 to Mar 2013 Sales Associate/cashier/ manangement/customer service
Education:
On the job training Davis, CA 2001 to 2004 Pharmacy TechnicianSan Francisco State University San Francisco, CA 1986 to 1992 Classical History w/ emphasis on World Religions
Doubletree by hilton - Maintenance Manager Seaham Hall hotel - Maintenance Manager Percy Hedley School - Maintenance Officer Sunderland Health & Racquet Club - Building Services Manager
Education:
Redewood
Paul Webb
Work:
Maidenhead Aquatics - Sales Assistant
Education:
Swavesey Village College
Relationship:
In_a_relationship
Paul Webb
Work:
Allwight - Director Foundation Multimedia - Director
business development manager at Gradus Ltd Been with Gradus for 20 years now ! and been in flooring for over 30 years worked for the likes of Forbo,Armstrong as well as working in distribution,
Paul Webb, a professor of politics at the University of Sussex, said that based on analysis of the 2017 election, even in those Leave-voting areas, The overwhelming majority of people who voted for Labour in those seats were Remainers, and they werent Leavers. So they might have been majority Leav
Hollis was a founding member of Talk Talk alongside drummer Lee Harris and bassist Paul Webb. He released five records with Talk Talk before the group broke up after 1991s Laughing Stock due to label troubles and legal disputes. He released one self-titled solo album in 1998 before retiring from th
Date: Feb 26, 2019
Category: Headlines
Source: Google
Jeremy Corbyn, at Labour Party Conference, Faces Pressure on New Brexit Vote
To constitute the majority in Parliament that you would need to have a second referendum, the opposition party is pretty important, said Paul Webb, a professor of politics at the University of Sussex in England. So it could be a game-changer.
Date: Sep 23, 2018
Category: Headlines
Source: Google
US stock futures turn lower as Deutsche Bank worries persist
The perception on Wall Street is that [Clinton] would be the safer pair of hands, but with two further debates and six more weeks of campaigning to go, this race seems set to be a bountiful source of market volatility in the near term, Paul Webb, deputy CEO at ADS Securities London, in a note.
Date: Sep 27, 2016
Category: Business
Source: Google
Labour Leadership: How Many Supporters Will Pay £25 To Save Corbyn?
Tim Bale, Professor of Politics, Queen Mary University of London; Monica Poletti, ESRC Postdoctoral Research Assistant, Queen Mary University of London, and Paul Webb, Professor of Politics, University of Sussex
Date: Jul 20, 2016
Category: World
Source: Google
As Britain gears up for election, a lot more players on the stage
Paul Webb, professor of politics at Sussex University, agrees that competent coalition and minority devolved governments in Wales, Northern Ireland, and Scotland have encouraged multiparty democracy. He said the "success" of the coalition government of the Conservatives and Lib Dems over the past fi
Date: Mar 31, 2015
Category: World
Source: Google
Black business leaders expand campaign of free tickets for students to see 'Selma'
esent SELMA. Produced by Christian Colson, Dede Gardner, Jeremy Kleiner, Oprah Winfrey, the film is executive produced by Brad Pitt, Cameron McCracken, Diarmuid McKeown, Nik Bower, Ava DuVernay, Paul Garnes and Nan Morales. The film is written by Paul Webb. SELMA is directed by Ava DuVernay.
Date: Jan 21, 2015
Category: Entertainment
Source: Google
VIDEO: John Legend and Common Perform 'Glory' on Selma's Edmund Pettus ...
aramount Pictures, Path, and Harpo Films present SELMA. Produced by Christian Colson, Dede Gardner, Jeremy Kleiner, Oprah Winfrey, the film is executive produced by Brad Pitt, Cameron McCracken, Diarmuid McKeown, Nik Bower, Ava DuVernay, Paul Garnes and Nan Morales. The film is written by Paul Webb.
Date: Jan 19, 2015
Category: Entertainment
Source: Google
Youtube
Improve Communication to Improve Sales - NLP ...
How you communicate - the words that you choose - can either make the ...
Duration:
10m 4s
Paul Webb ANYTIME SALES TRAINING
"Who Is Your Customer?" - Paul Webb explains how knowing your customer...
Duration:
5m 15s
Paul Webb - (Part 1)
Duration:
10m 1s
Talk Talk interview 1986 /Mark Hollis Paul We...
Another small interview on Countdown 1986. Mark Hollis, Paul Webb, Lee...
Duration:
1m 1s
Talk Talk/Mark Hollis/Paul Webb/Lee Harris - ...
The full show Crackerjackis here .
Duration:
2m 58s
Beth Gibbons & Rustin Man - Mysteries
Beth Gibbons and Rustin Man in concert in France. Beth, Adrian and Pau...