Paul B Westberg

US Patent:

8410075, Apr 2, 2013

Filed:

Sep 21, 2009

Appl. No.:

12/563543

Inventors:

John F. W. Keana - Eugene OR, US
Paul Westberg - San Mateo CA, US
John Curd - Hillsborough CA, US
Alshad S. Lalani - Briarcliff Manor NY, US

Assignee:

Cascade Prodrug Inc. - Eugene OR

International Classification:

A01N 43/04
A61K 31/70

US Classification:

514 50, 514 43, 514 49, 514 51

Abstract:

Disclosed are Mannich base N-oxides of drugs containing acidic N—H groups. Pharmaceutical compositions comprising a therapeutically effective amount of Mannich base N-oxides, or a N-oxide rearrangement product, pharmaceutically acceptable salt or prodrug thereof, are also disclosed. Further, disclosed are methods of using the compounds, alone or in combination with one or more other active agents or treatments.

US Patent:

20080305075, Dec 11, 2008

Filed:

Apr 29, 2008

Appl. No.:

12/111672

Inventors:

John G. Curd - Hillsborough CA, US
John F.W. Keana - Eugene OR, US
Alshad S. Lalani - Tarrytown NY, US
Paul B. Westberg - San Mateo CA, US
Bradford Goodwin - San Mateo CA, US
W. David Henner - Tucson AZ, US

International Classification:

A61K 31/475
C07D 471/04
A61P 35/00
A61K 39/395
A61K 38/20
A61K 38/21
A61K 31/4375
A61K 31/55

US Classification:

424 852, 540579, 540478, 51421402, 514283, 4241411, 424 857

Abstract:

The present invention relates to vinca alkaloid and analog N-oxides having activity for treating hyperproliferative disorders. Further, the invention relates to pharmaceutical compositions and methods of using vinca alkaloid and analog N-oxides, alone or in combination with one or more other active agents or treatments, to treat hyperproliferative disorders.

US Patent:

20120107230, May 3, 2012

Filed:

Oct 25, 2011

Appl. No.:

13/280974

Inventors:

JOHN G. CURD - HILLSBOROUGH CA, US
JOHN F.W. KEANA - EUGENE OR, US
ALSHAD S. LALANI - TERRYTOWN NY, US
PAUL B. WESTBERG - SAN MATEO CA, US
BRADFORD GOODWIN - SAN MATEO CA, US
W. DAVID HENNER - TUCSON AZ, US

Assignee:

UNIVERSITY OF OREGON - EUGENE OR

International Classification:

A61K 31/475
A61P 35/02
A61P 29/00
A61P 17/00
A61P 27/02
A61P 1/00
A61P 1/16
A61P 37/06
A61P 37/02
A61P 17/06
A61P 9/14
A61K 51/00
A61K 39/395
A61K 35/74
A61K 31/704
A61K 38/21
A61K 38/44
A61K 31/513
A61K 31/713
A61K 38/20
A61K 31/664
A61K 38/46
A61P 35/00

US Classification:

424 111, 514283, 4241451, 4241581, 4241331, 424 9346, 514 34, 424 857, 424 944, 514274, 514 44 A, 424 852, 514110, 424 946, 4241721

Abstract:

The present invention relates to vinca alkaloid and analog N-oxides having activity for treating hyperproliferative disorders. Further, the invention relates to pharmaceutical compositions and methods of using vinca alkaloid and analog N-oxides, alone or in combination with one or more other active agents or treatments, to treat hyperproliferative disorders.