Paul Johnston Wilkinson

US Patent:

20210387161, Dec 16, 2021

Filed:

Aug 27, 2021

Appl. No.:

17/458556

Inventors:

- San Diego CA, US
Paul R. Wilkinson - El Segundo CA, US
Steven Yamamoto - San Diego CA, US

Assignee:

Matrix Sensors, Inc. - San Diego CA

International Classification:

B01J 20/22
B05C 11/10

Abstract:

An apparatus and method is provided for coating a surface of a substrate with at least one film of porous coordination polymer. A body has an interior space for holding the substrate to be coated, at least one inlet, and at least one outlet in communication with the interior space to permit fluid to flow in a downstream direction from the inlet, across the surface of the substrate in the interior space, and through the outlet. A plurality of flow channels are arranged to flow a plurality of different reagent solutions from respective supply sources to the at least one inlet. The flow channels merge into at least one mixing region, positioned upstream of the interior space, to mix the solutions prior to the mixture contacting the surface of the substrate in the interior space. At least one pressure source and valve system are arranged with the supply sources and the flow channels to select at least one combination of the reagent solutions to be mixed and to force the selected reagent solutions to flow from their respective supply sources, through the flow channels, and into the mixing region at different, independently controllable flow rates to regulate respective concentrations of reagents in the mixture.

US Patent:

20210285126, Sep 16, 2021

Filed:

Mar 10, 2021

Appl. No.:

17/198204

Inventors:

- San Diego CA, US
Paul R. Wilkinson - El Segundo CA, US
Steven Yamamoto - San Diego CA, US

Assignee:

MATRIX SENSORS, INC. - San Diego CA

International Classification:

C30B 28/04
C08J 5/18
C07F 9/00
G01G 3/16
C30B 29/58
C07F 15/04

Abstract:

An apparatus and method is provided for coating a surface of a material with a film of porous coordination polymer. A first substrate having a first surface to be coated is positioned in a processing chamber such that the first surface is placed in a substantially opposing relationship to a second surface. In some embodiments, the second surface is provided by a wall of the processing chamber, and in other embodiments the second surface is provided by a second substrate to be coated. The first substrate is held such that a gap exists between the first and second surfaces, and the gap is filled with at least one reaction mixture comprising reagents sufficient to form the crystalline film on at least the first surface. A thin gap (e.g., having a thickness less than 2 mm) between the first and second surfaces is effective for producing a high quality film having a thickness less than 100 μm. Confining the volume of the reaction mixture to a thin layer adjacent the substrate surface significantly reduces problems with sedimentation and concentration control. In some embodiments, the size, shape, or average thickness of the gap is adjusted during formation of the film in response to feedback from at least one film growth monitor.

US Patent:

20190255510, Aug 22, 2019

Filed:

Apr 29, 2019

Appl. No.:

16/398005

Inventors:

- San Diego CA, US
Paul R. Wilkinson - El Segundo CA, US
Steven Yamamoto - San Diego CA, US

Assignee:

MATRIX SENSORS, INC. - San Diego CA

International Classification:

B01J 20/22

Abstract:

An apparatus and method is provided for coating a surface of a substrate with at least one film of porous coordination polymer. A body (e.g., a flow cell) has an interior space for holding the substrate to be coated, at least one inlet, and at least one outlet in communication with the interior space to permit fluid to flow in a downstream direction from the inlet, across the surface of the substrate in the interior space, and through the outlet. A plurality of flow channels are arranged to flow a plurality of different reagent solutions from respective supply sources to the at least one inlet. The flow channels merge into at least one mixing region, positioned upstream of the interior space, to mix the solutions prior to the mixture contacting the surface of the substrate in the interior space. At least one pressure source and valve system are arranged with the supply sources and the flow channels to select at least one combination of the reagent solutions to be mixed and to force the selected reagent solutions to flow from their respective supply sources, through the flow channels, and into the mixing region at different, independently controllable flow rates to regulate respective concentrations of reagents in the mixture.

US Patent:

20180202961, Jul 19, 2018

Filed:

Jan 17, 2018

Appl. No.:

15/872999

Inventors:

- San Diego CA, US
Paul R. Wilkinson - El Segundo CA, US
Steven Yamamoto - San Diego CA, US
David K. Britt - El Cerrito CA, US

Assignee:

MATRIX SENSORS, INC. - San Diego CA

International Classification:

G01N 27/327
G01N 27/02
A61B 5/055

Abstract:

A device and method are provided for detecting analyte with correction for the effects of humidity. The device comprises a resonant sensor having an oscillating portion. A capacitor is positioned on the oscillating portion. The capacitor is formed by at least two electrodes and a sensing material positioned between the electrodes. A readout circuit is arranged to measure a response of the oscillating portion (e.g., frequency shift or change in resonance frequency, stiffness or strain) and a capacitance of the capacitor when substances are adsorbed or absorbed in the sensing material. This combination of measurements enables the device to distinguish between various types of adsorbed or absorbed molecules, especially distinguishing between an analyte of interest and water molecules that might interfere with the detection of the analyte. A processor determines an analyte value indicative of the presence, amount or concentration of the analyte in dependence upon measurements of both the response of the oscillating portion and the capacitance to account for the effects of water in the sensing material.

US Patent:

20170231499, Aug 17, 2017

Filed:

Aug 10, 2015

Appl. No.:

15/503371

Inventors:

James K. GIMZEWSKI - Topanga CA, US
Shivani SHARMA - El Segundo CA, US
Paul WILKINSON - El Segundo CA, US
Nagesh RAGAVENDRA - Malibu CA, US
JianYu RAO - Los Angeles CA, US
M. Dayan J. WICKRAMARATNE - Los Angeles CA, US
- Oakland CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61B 5/00
A61B 10/00
A61B 10/02
A61B 5/06

Abstract:

In one aspect, an elastography system includes an elastography device and a position sensing device connected to the elastography device. The elastography device includes a housing, a probing element removably attached to the housing, and a force sensor attached within the housing, where the force sensor is connected to the probing element. In another aspect, an elastography) method includes inserting a probing element into a material, producing, by a force sensor connected to a base of the probing element a signal indicative of a force applied to the probing element upon insertion of the probing element into the material, and based on the signal, deriving a mapping of spatial variations of a material property within the material.

US Patent:

20170173623, Jun 22, 2017

Filed:

Dec 19, 2016

Appl. No.:

15/383548

Inventors:

- San Diego CA, US
Paul R Wilkinson - El Segundo CA, US
Steven Yamamoto - San Diego CA, US

Assignee:

MATRIX SENSORS, INC. - San Diego CA

International Classification:

B05C 9/02
B05C 21/00
B05D 1/30
B05D 1/34
B05D 7/14
B05C 9/10
B05C 9/14

Abstract:

An apparatus and method is provided for coating a surface of a material with at least one film of porous coordination polymer. A body (e.g., a flow cell) has an interior space for holding the material to be coated, at least one inlet, and at least one outlet in communication with the interior space to permit fluid to flow in a downstream direction from the inlet, across the surface of the material in the interior space, and through the outlet. A plurality of flow channels are arranged to flow a plurality of different reagent solutions from respective supply sources to the at least one inlet. The flow channels merge into at least one mixing region, positioned upstream of the interior space, to mix the solutions prior to the mixture contacting the surface of the material in the interior space. At least one pressure source and valve system are arranged with the supply sources and the flow channels to select at least one combination of the reagent solutions to be mixed and to force the selected reagent solutions to flow from their respective supply sources, through the flow channels, and into the mixing region at independently controllable flow rates to regulate respective concentrations of reagents in the mixture.

US Patent:

20150177196, Jun 25, 2015

Filed:

Dec 20, 2013

Appl. No.:

14/137990

Inventors:

- San Diego CA, US
Paul R. Wilkinson - El Segundo CA, US

Assignee:

MATRIX SENSORS, INC. - San Diego CA

International Classification:

G01N 29/24
G01N 27/22

Abstract:

A sensor array includes at least first and second resonator sensors. A receptor material on the first sensor is hydrophilic relative to a receptor material on the second sensor, and the receptor material on the second sensor is hydrophobic relative to the receptor material on the first sensor. At least one detector measures sensor responses when masses of one or more of substances are adsorbed or bound to the sensors. A processor receives signals or data representative of the sensor responses. The processor is programmed to determine at least one humidity value according to the sensor responses.