Paul H Wooley

US Patent:

20120095558, Apr 19, 2012

Filed:

Oct 13, 2011

Appl. No.:

13/272793

Inventors:

Paul Hastings Wooley - Wichita KS, US
Haiying Yu - Wichita KS, US

Assignee:

CIBOR, INC. - Wichita KS

International Classification:

A61F 2/28
A61K 36/04
A61K 31/765
A61K 35/32
A61K 33/42
A61K 35/14
A61K 48/00
A61K 39/395
A61K 38/43
A61K 38/02
A61P 19/08
A61K 35/12
A61K 9/00
A61K 31/711

US Classification:

623 1611, 424400, 42419517, 424 7838, 424549, 424602, 514 44 R, 4241411, 4241301, 424 941, 514 167, 424 937, 424529, 424520

Abstract:

A porous, self-sustaining body useful as a scaffold for bone grafting is provided. The scaffold comprises a carbonaceous matrix comprising a continuous phase having a surface and defining a plurality of open spaces throughout the matrix. The internal and external surfaces of the matrix are coated with a layer or film selected from the group consisting of osteogenic materials, therapeutic agents, and combinations thereof. The porous body comprises organic materials and is substantially free of metals. Methods of making and using the porous self-sustaining body are also provided, along with kits for facilitating the same.

US Patent:

20120185047, Jul 19, 2012

Filed:

Jan 17, 2012

Appl. No.:

13/351578

Inventors:

Paul Hastings Wooley - Wichita KS, US

Assignee:

CIBOR, INC. - Wichita KS

International Classification:

A61F 2/44
B05D 3/00
B05D 7/00

US Classification:

623 1716, 427 226

Abstract:

An intervertebral implant for placement in the intervertebral space between two adjacent vertebral bodies is provided. The implant comprises a hollow cage and a porous core received within the cage. The cage comprises a superior surface configured to contact a first vertebral body, an inferior surface configured to contact a second vertebral body, and an outer wall extending between the superior surface and inferior surface. The outer wall comprises an exterior surface defining the outer perimeter of the implant, and an interior surface defining an inner (hollow) space or void. The porous core is received within the inner space or void, and preferably fills the void. The core comprises a carbonaceous matrix comprising a continuous phase having a surface and defining a plurality of open spaces throughout said matrix. Suitable carbonaceous matrices are selected from the group consisting of carbon foam, graphite foam, and combinations thereof. Methods of making and using the same, along with kits to facilitate such use are also provided.

US Patent:

20120265001, Oct 18, 2012

Filed:

Oct 11, 2011

Appl. No.:

13/271172

Inventors:

Ramazan Asmatulu - Wichita KS, US
Heath Misak - Wichita KS, US
Paul Wooley - Wichita KS, US

Assignee:

WICHITA STATE UNIVERSITY - Wichita KS

International Classification:

A61K 9/14
A61K 31/519
A61K 33/24
A61P 35/00
A61N 2/10
A61K 47/34
A61K 31/513
A61P 29/00
B82Y 5/00

US Classification:

600 12, 514274, 514249, 424649, 424400, 514769, 977773, 977838, 977810, 977906

Abstract:

A composite magnetic nanoparticle drug delivery system provides targeted controlled release chemotherapies for cancerous tumors and inflammatory diseases. The magnetic nanoparticle includes a biocompatible and biodegradable polymer, a magnetic nanoparticle, the biological targeting agent human serum albumin, and a therapeutic pharmaceutical composition. The composite nanoparticles are prepared by oil-in-oil emulsion/solvent evaporation and high shear mixing. An externally applied magnetic field draws the magnetic nanoparticles to affected areas. The biological targeting agent draws the nanoparticles into the affected tissues. Polymer degradation provides controlled time release delivery of the pharmaceutical agent.