Anita Shukla - Houston TX, US Paula T. Hammond - Newton MA, US
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:
A61M 37/00 B05D 5/00
US Classification:
604500, 604 9301, 427 231
Abstract:
The present disclosure provides, am ng other things, a coated device comprising: a porous substrate; a film coating at least part of the substrate, which film comprises a multilayer unit comprising a first layer and a second layer adjacent to the first layer, wherein the first layer comprises a first polymeric material and at least first interacting moiety, wherein the second layer comprises a second polymeric material and at least second interacting moiety, and wherein the interacting moieties on adjacent layers interact with one another so that the adjacent layers are associated with each other into the film; and an agent for delivery associated with the coated device, such that decomposition of one or more layers of the film results in release of the agent.
Anita Shukla - Houston TX, US Paula T. Hammond - Newton MA, US
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:
A61F 2/82 A61F 2/24 B05D 1/02
US Classification:
623 143, 427 21, 623 142, 623 242
Abstract:
In various embodiments, a coated device comprises: a substrate; a film coating at least part of the substrate, which film comprises a multilayer unit comprising a first layer and a second layer associated with one another via a hydrogen bond, wherein the first layer comprises a first natural polymeric material and a hydrogen bond donor and wherein the second layer comprises a second natural polymeric material and a hydrogen bond acceptor; and an agent for delivery associated with the coated device. In various embodiments, a coated device comprises: a substrate; a film coating at least part of the substrate, which film comprises a multilayer unit comprising a tetralayer with alternating layers of opposite charge; and an agent for delivery associated with the coated device.
"What was especially remarkable about these results was the level of recovery from severe injury we saw in the animal studies," says chemical engineer Paula Hammond from MIT. "By introducing two complementary systems in sequence, it is possible to get a much stronger clot."
Date: May 10, 2023
Category: Health
Source: Google
Two-component system could offer a new way to halt internal bleeding
y introducing two complementary systems in sequence it is possible to get a much stronger clot, says Paula Hammond, an MIT Institute Professor, the head of MITs Department of Chemical Engineering, a member of the Koch Institute for Integrative Cancer Research, and one of the senior authors of a pa
Its been a real struggle to try to design a delivery system that allows us to administer siRNA, especially if you want to target it to a specific part of the body, MIT Engineering Professor Paula Hammond explained in a statement.