Paula M Pitha-Rowe

US Patent:

6498033, Dec 24, 2002

Filed:

Mar 13, 2000

Appl. No.:

09/524004

Inventors:

Boro Dropulic - Ellicott City MD
Paula Pitha-Rowe - Baltimore MD

Assignee:

The Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

C12N 1586

US Classification:

4353201, 435 691, 435 913, 435 9131, 435 914, 435455, 435456, 536 231, 536 2372, 536 245

Abstract:

The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating and selectively packaging, and using such a vector, isolated molecules of specified nucleotide and amino acid sequences relevant to such vectors, a pharmaceutical composition and a host cell comprising such a vector, the use of such a host cell to screen drugs. The methods include the prophylactic and therapeutic treatment of viral infection, in particular HIV infection, and, thus, are also directed to viral vaccines and the treatment of cancer, in particular cancer of viral etiology. Other methods include the use of such conditionally replicating viral vectors in gene therapy and other applications.

US Patent:

20090136479, May 28, 2009

Filed:

Jun 28, 2005

Appl. No.:

11/630544

Inventors:

Paula M. Pitha-Rowe - Baltimore MD, US
Atsushi Okumura - Cockeysville MD, US
Myriam S. Kunzi - Annandale VA, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 39/395
C12N 5/06
C12N 15/00

US Classification:

4241301, 435375, 4353201

Abstract:

The instant invention provides methods for the treatment and prevention of viral infection, e.g., HIV infection, based on the discovery that viral replication utilizes the ubiquitination pathway of the host cell to replicate. Specifically, the invention provides methods for the treatment and prevention of viral infection, e.g., HIV infection, by modulation of ISG15 conjugation and deconjugation, e.g., by modulation of the activity or expression of UBP43 or UBEL-1.

US Patent:

20110269229, Nov 3, 2011

Filed:

Apr 13, 2011

Appl. No.:

13/086241

Inventors:

Paula M. Pitha-Rowe - Baltimore MD, US
Atsushi Okumura - Bryn Mawr PA, US
Myriam S. Kunzi - Annandale VA, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

C12N 5/071

US Classification:

435375

Abstract:

The instant invention provides methods for the treatment and prevention of viral infection, e.g., HIV infection, based on the discovery that viral replication utilizes the ubiquitination pathway of the host cell to replicate. Specifically, the invention provides methods for the treatment and prevention of viral infection, e.g., HIV infection, by modulation of ISG15 conjugation and deconjugation, e.g., by modulation of the activity or expression of UBP43 or UBEL-1.

US Patent:

6410257, Jun 25, 2002

Filed:

May 1, 2000

Appl. No.:

09/562894

Inventors:

Boro Dropulic - Ellicott City MD
Paula Pitha-Rowe - Baltimore MD

Assignee:

The Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

C12N 1509

US Classification:

435 29, 4353201, 435456, 435457, 536 231, 536 245

Abstract:

The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating and selectively packaging, and using such a vector, isolated molecules of specified nucleotide and amino acid sequences relevant to such vectors, a pharmaceutical composition and a host cell comprising such a vector, the use of such a host cell to screen drugs. The methods include the prophylactic and therapeutic treatment of viral infection, in particular HIV infection, and, thus, are also directed to vital vaccines and the treatment of cancer, in particular cancer of viral etiology. Other methods include the use of such conditionally replicating viral vectors in gene therapy and other applications.