Pavankumar Nv Petluru

US Patent:

7238823, Jul 3, 2007

Filed:

Jan 26, 2006

Appl. No.:

11/340048

Inventors:

Zejun Xiao - San Antonio TX, US
Frederick H. Hausheer - Boerne TX, US
Pavankumar Petluru - San Antonio TX, US

Assignee:

BioNumerik Pharmaceuticals, Inc. - San Antonio TX

International Classification:

C07F 15/00
A61K 31/28

US Classification:

556137, 546 2, 548101, 514359, 514492

Abstract:

Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming hydrogen bonds with the bases in DNA or RNA and leaving groups (i. e. , Land L) which can be hydrolyzed in vivo to active species, which can then form coordinate adducts with DNA or RNA at the Guanine or Adenine bases thereof. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as methods of treatment of various types of cancer by the administration of a pharmaceutically-effective dose of said novel platinum complexes.

US Patent:

7569606, Aug 4, 2009

Filed:

Apr 17, 2006

Appl. No.:

11/405141

Inventors:

Zejun Xiao - San Antonio TX, US
Frederick H. Hausheer - Boerne TX, US
Pavankumar Petluru - San Antonio TX, US

Assignee:

BioNumerik Pharmaceuticals, Inc. - San Antonio TX

International Classification:

A61K 31/28
C07F 15/00

US Classification:

514492, 514359, 546 2, 548101, 556137

Abstract:

Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming hydrogen bonds with the bases in DNA or RNA and leaving groups (i. e. , Land L)which can be hydrolyzed iii vivo to active species, which can then form coordinate adducts with DNA or RNA at the Guanine or Adenine bases thereof. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as methods of treatment of various types of cancer by the administration of a pharmaceutically-effective dose of said novel platinum complexes.

US Patent:

20080194680, Aug 14, 2008

Filed:

Oct 30, 2007

Appl. No.:

11/978818

Inventors:

Xinghai Chen - San Antonio TX, US
Pavankumar N.V. Petluru - San Antonio TX, US
Qiuli Huang - San Antonio TX, US
Kesavaram Narkunan - San Antonio TX, US
Frederick Hausheer - Boerne TX, US

International Classification:

A61K 31/282
C07F 15/00
A61P 35/00

US Classification:

514492, 556137

Abstract:

Disclosed herein are novel platinum-based analogs possessing two nitrile substituent groups (bis-nitrile) covalently-bonded to the platinum. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as quantitative in vitro IC50 data.

US Patent:

20140073793, Mar 13, 2014

Filed:

Sep 7, 2012

Appl. No.:

13/573294

Inventors:

Xinghai Chen - San Antonio TX, US
Harry Kochat - San Antonio TX, US
Pavankumar N.V. Petluru - San Antonio TX, US
Aulma Parker - San Antonio TX, US
Frederick H. Hausheer - Fair Oaks Ranch TX, US

International Classification:

C07F 7/30

US Classification:

546 10

Abstract:

The present invention discloses: (i) the novel germanium-containing camptothecin compound, 7[2′-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts thereof; (ii) methods of synthesis of said novel germanium-containing camptothecin compound, 7[2′-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts; (iii) pharmaceutically-acceptable formulations comprising said novel germanium-containing camptothecin compound, 7[2′-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts thereof; and (iv) methods of administration of said novel germanium-containing camptothecin compound, 7[2′-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts thereof to subjects in need thereof, including subjects with cancer.

US Patent:

59104910, Jun 8, 1999

Filed:

Aug 19, 1997

Appl. No.:

8/914207

Inventors:

Frederick H. Hausheer - Boerne TX
Pavankumar N.V. Petluru - San Antonio TX
Dasharatha Reddy - San Antonio TX
Dhanabalan Murali - San Antonio TX
Kochat Haridas - San Antonio TX
Shijie Yao - San Antonio TX

Assignee:

BioNumerik Pharmaceuticals, Inc. - San Antonio TX

International Classification:

C07D49122

US Classification:

514 63

Abstract:

Novel compounds, formulations and methods of treating patients with cancer are provided for in this invention. The compounds are derivatives of camptothecin, and specifically relate to compounds having novel substitutions at the C-7 position of the camptothecin scaffold B-ring. The formula I compounds are highly lipophilic, lactone stable, do not require metabolic activation, and are potent antineoplastic compounds.

US Patent:

61690805, Jan 2, 2001

Filed:

Feb 11, 1998

Appl. No.:

9/022310

Inventors:

Frederick H. Hausheer - Boerne TX
Kochat Haridas - San Antonio TX
P. Seetharamulu - San Antonio TX
Dasharatha G. Reddy - San Antonio TX
Shijie Yao - San Antonio TX
Pavankumar N.V. Petluru - San Antonio TX
Dhanabalan Murali - San Antonio TX

Assignee:

BioNumerik Pharmaceuticals, Inc. - San Antonio TX

International Classification:

A61K 31475
A61K 31695
C07D49122
A61P 3500

US Classification:

514 63

Abstract:

This invention relates to novel derivatives of camptothecin, and will, particularly to derivatives having a substitution at the C-7 position, or at one of the C-9, C-10, C-11 or C-12 positions, or to disubstituted derivatives having a first substitution at C-7 and a second at one of C-9, C-10, C-11 or C-12. The invention also includes methods of using the compounds as Topoisomerase I inhibitors to treat patients with cancer. The invention also includes pharmaceutical formulations which consist of the novel compounds in solution or suspension with one or more pharmaceutical excipients or dilutes.