A water insoluble, biocompatible gel is prepared by reacting carboxymethylcellulose and a carbodiimide, wherein the reaction is conducted in an aqueous medium containing a water miscible organic solvent, such as a lower alkanol, an alkyl pyrrolidone, DMSO or acetone. The present method permits the reaction to contain higher concentrations of carboxymethycellylose and less carbodiimide than conventional methods.
Modification Of Biopolymers For Improved Drug Delivery
A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a suitable carrier, has improved in vivo stability and activity, and can be targeted to a variety of cells, tissues and organs.
Pericles Calias - East Boston MA, US Robert J. Miller - East Sandwich MA, US James R. Olson - Norwich CT, US
Assignee:
Genzyme Corporation - Cambridge MA
International Classification:
A61K 9/10 A61K 47/44 A61K 47/34
US Classification:
424486, 5147727, 514786, 514787
Abstract:
Degradable blend of polycaprolactone and crystallization modifier especially suitable for use in the controlled release of biologically active proteins.
Biologically Active Conjugate Of A Biopolymer And Therapeutic Agent
A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a suitable carrier, has improved in vivo stability and activity, and can be targeted to a variety of cells, tissues and organs.
Immunodulatory Compositions And Methods Of Use Thereof
Pericles Calias - Melrose MA, US Robert J. Miller - Halifax MA, US Andrew B. Onderdonk - Westwood MA, US Arthur O. Tzianabos - Reading MA, US
Assignee:
Genzyme Corporation - Cambridge MA The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K 31/17
US Classification:
514588, 514825
Abstract:
The invention relates to immunomodulatory compositions and related methods. The immunomodulatory compositions of a formula disclosed herein are useful for the prevention of sepsis and the treatment and prevention of diseases associated with inflammation and/or NOS.
Detection Of Oligonucleotides By Dual Hybridization
David T. Shima - Herts, GB Pericles Calias - Melrose MA, US Gregory S. Robinson - Wilmington MA, US John P. Wing - Walpole MA, US Lori M. Mullin - West Townsend MA, US Lillian M. Smith - Lynn MA, US Ervin Sinani - Revere MA, US
Assignee:
Eyetech, Inc. - Palm Beach Gardens FL
International Classification:
C12Q 1/68 C07H 21/02 C07H 21/04
US Classification:
435 6, 536 231, 536 243
Abstract:
The invention provides methods and compositions for detecting and/or quantifying modified nucleic acid oligonucleotides. These methods and compositions are useful for detecting and quantifying diagnostic and/or therapeutic synthetic modified oligonucleotides, such as aptamers, RNAi, siRNA, antisense oligonucleotides or ribozymes in a biological sample.
Methods And Compositions For Cns Delivery Of Iduronate-2-Sulfatase
Gaozhong Zhu - Weston MA, US Kris Lowe - Boston MA, US Zahra Shahrokh - Weston MA, US James Christian - Grafton MA, US Richard Fahmer - Boxford MA, US Jing Pan - Boxborough MA, US Teresa Leah Wright - Lexington MA, US Pericles Calias - Melrose MA, US
Assignee:
Shire Human Genetic Therapies, Inc. - Lexington MA
International Classification:
A61K 38/46 A61P 25/00
US Classification:
424 943
Abstract:
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
Drug Delivery Device And Syringe For Filling The Same
Wisam Breegi - Woburn MA, US Pericles Calias - Melrose MA, US Anthony Adamis - Boston MA, US David Shima - Boston MA, US Emmett Cunningham - New York NY, US
International Classification:
A61K009/22
US Classification:
604/891100
Abstract:
The invention relates to the field of drug delivery devices. More particularly, the invention relates to implantable, refillable drug delivery devices which provide for drug delivery over sustained time periods. The present invention has particular application for ophthalmic drug delivery applications.