Peter Burkhard from Storrs Mansfield, CT, age 63

Self-Assembling Peptide Nanoparticles Useful As Vaccines
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US Patent:

20110020378, Jan 27, 2011
Filed:

Jan 29, 2009
Appl. No.:

12/864576
Inventors:

Peter BURKHARD - Mansfield Center CT, US
International Classification:

A61K 39/00
C07K 2/00
C07K 14/00
A61P 37/04
C07K 14/155
C07K 14/445
C07K 14/11
US Classification:

4241841, 530300, 530350, 977773, 977917
Abstract:

Self-assembling peptide nanoparticles (SAPN) incorporating T-cell epitopes and/or B-cell epitopes are described. The nanoparticles of the invention consist of aggregates of a continuous peptidic chain comprising two oligomerization domains connected by a linker segment wherein one or both oligomerization domains incorporate T-cell epitopes and/or B-cell epitopes within their peptide sequence. These nanoparticles are useful as vaccines and adjuvants.

Malaria Vaccine Of Self-Assembling Polypeptide Nanoparticles
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US Patent:

20120015000, Jan 19, 2012
Filed:

Jun 29, 2009
Appl. No.:

13/056298
Inventors:

David Lanar - Takoma Park MD, US
Peter Burkhard - Mansfield Center CT, US
International Classification:

A61K 9/14
A61P 33/06
A61K 39/015
A61P 37/04
B82Y 5/00
US Classification:

424400, 4242721, 4241911, 4241921, 977773, 977917
Abstract:

The invention is directed to functionalized self-assembling polypeptide nanoparticles, and to methods of using these nanoparticles to vaccinate against malaria. The functionalized SAPN comprises a self-assembling core, and at least one epitope fused to the self-assembling core. The self-assembling core comprises a pentameric coiled-coil domain, a trimeric coiled-coil domain, and a linker. The linker joins the pentameric coiled-coil domain and the trimeric coiled-coil domain. Particular sequences of the epitopes used in the vaccine are from the parasite.