Peter W Conway

US Patent:

20230058647, Feb 23, 2023

Filed:

Aug 19, 2022

Appl. No.:

17/891863

Inventors:

- Woburn MA, US
Douglas G. Sabin - Marblehead MA, US
Peter Conway - Groton MA, US
Jacob Freake - Somerville MA, US
Corbin Munn - New York NY, US
Joseph Von Shoppe - Medford MA, US
Renee Hester - Boston MA, US
Emily Geishecker - Burlington MA, US
Shiny Rajan - Woburn MA, US
Abraham LeMole - Boston MA, US

International Classification:

C12M 3/06
C12M 1/00
C12M 1/34
C12M 1/26
C12M 3/00
C12M 1/36

Abstract:

This disclosure describes hardware for microfluidic chips and an associated support module for facilitating operation of one or more microfluidic chips. The microfluidic chips described herein are designed for supporting multiple different tissue types, including kidney tissue, liver tissue, adipose cells, and so forth. Chip geometry facilities fluid flow through one or more channels of the chip with a particular flow rate. For example, shear forces are reduced where needed to ensure proper flow rate of fluid in the channels. The chamber geometry and the geometry of the channels ensures that a desired amount of oxygen is delivered to sample cells or tissues in a controlled manner.