Peter H Davies

US Patent:

6864062, Mar 8, 2005

Filed:

Dec 12, 2001

Appl. No.:

10/017822

Inventors:

Raymond P. Zinkowski - Northbrook IL, US
Daniel J. Kerkman - Lake Villa IL, US
Russell E. Kohnken - Skokie IL, US
John F. DeBernardis - Lindenhurst IL, US
Peter Davies - Rye NY, US

Assignee:

Molecular Geriatrics Corporation - Vernon Hills IL

International Classification:

G01N033/53
G01N033/559
G01N033/564

US Classification:

435 71, 435 792, 435 793, 435 794, 435 795, 436507

Abstract:

The invention relates, among other things, a preparation comprising Alzheimer's disease antigen (A68), as well as methods of obtaining this purified antigen, and methods of using this purified antigen, for instance, for diagnosing Alzheimer's disease and for detecting human autoantibodies to the Alzheimer disease antigen. The antigen preparation according to the invention is purified in that it is substantially free of immunoglobulin G. The invention further relates to methods of making Alzheimer disease antigens that can be used instead of or along with the A68 antigen preparation (e. g. , for diagnosing AD), such as recombinant human tau, tau isolated from various species including human, and phosphorylated recombinant human tau or isolated tau, as well as A68 anti-idiotypic antibodies.

US Patent:

20020002270, Jan 3, 2002

Filed:

Jun 16, 1999

Appl. No.:

09/334582

Inventors:

RAYMOND P. ZINKOWSKI - NORTHBROOK IL, US
DANIEL J. KERKMAN - LAKE VILLA IL, US
RUSSELL E. KOHNKEN - SKOKIE IL, US
JOHN F. DEBERNARDIS - LINDENHURST IL, US
PETER DAVIES - RYE NY, US

International Classification:

C07K016/00
G01N033/53
G01N033/566

US Classification:

530/387100, 435/007100, 436/501000

Abstract:

The invention relates, among other things, a preparation comprising Alzheimer's disease antigen (A68), as well as methods of obtaining this purified antigen, and methods of using this purified antigen, for instance, for diagnosing Alzheimer's disease and for detecting human autoantibodies to the Alzheimer disease antigen. The antigen preparation according to the invention is purified in that it is substantially free of immunoglobulin G. The invention further relates to methods of making Alzheimer disease antigens that can be used instead of or along with the A68 antigen preparation (e.g., for diagnosing AD), such as recombinant human tau, tau isolated from various species including human, and phosphorylated recombinant human tau or isolated tau, as well as A68 anti-idiotypic antibodies.

US Patent:

20050272094, Dec 8, 2005

Filed:

Mar 8, 2005

Appl. No.:

11/074958

Inventors:

Raymond Zinkowski - Northbrook IL, US
Daniel Kerkman - Lake Villa IL, US
Russell Kohnken - Skokie IL, US
John DeBernardis - Lindenhurst IL, US
Peter Davies - Rye NY, US

International Classification:

G01N033/53
C07K016/42

US Classification:

435007100, 530387200

Abstract:

The invention relates, among other things, a preparation comprising Alzheimer's disease antigen (A68), as well as methods of obtaining this purified antigen, and methods of using this purified antigen, for instance, for diagnosing Alzheimer's disease and for detectiing human autoantibodies to the Alzheimer disease antigen. The antigen preparation according to the invention is purified in that it is substantially free of immunoglobulin G. The invention further relates to methods of making Alzheimer disease antigens that can be used instead of or along with the A68 antigen preparation (e.g., for diagnosing AD), such as recombinant human tau, tau isolated from various species including human, and phosphorylated recombinant human tau or isolated tau, as well as A68 anti-idiotypic antibodies.

US Patent:

20080181883, Jul 31, 2008

Filed:

Apr 1, 2008

Appl. No.:

12/060350

Inventors:

Raymond P. Zinkowski - Northbrook IL, US
Daniel J. Kerkman - Lake Villa IL, US
Russel E. Kohnken - Skokie IL, US
John F. DeBernardis - Lindenhurst IL, US
Peter Davies - Rye NY, US

International Classification:

A61K 39/395
C07K 14/00
C07K 1/14
A61P 25/28

US Classification:

4241301, 530350, 530412

Abstract:

The invention relates, among other things, a preparation comprising Alzheimer's disease antigen (A68), as well as methods of obtaining this purified antigen, and methods of using this purified antigen, for instance, for diagnosing Alzheimer's disease and for detecting human autoantibodies to the Alzheimer disease antigen. The antigen preparation according to the invention is purified in that it is substantially free of immunoglobulin G. The invention further relates to methods of making Alzheimer disease antigens that can be used instead of or along with the A68 antigen preparation (e.g., for diagnosing AD), such as recombinant human tau, tau isolated from various species including human, and phosphorylated recombinant human tau or isolated tau, as well as A68 anti-idiotypic antibodies.

US Patent:

58113100, Sep 22, 1998

Filed:

Dec 23, 1994

Appl. No.:

8/362783

Inventors:

Hossein A. Ghanbari - Lake Forest IL
Peter Davies - Rye NY
Benjamin Wolozin - Columbia MD

Assignee:

Albert Einstein College of Medicine of Yeshiva Univ. - Bronx NY

International Classification:

G01N 3353

US Classification:

436518

Abstract:

The invention relates to an antigen associated with Alzheimer's disease and to antibodies specific for said antigen. This invention further relates to methods for diagnosing Alzheimer's disease utilizing assays containing Alzheimer's associated antigen, antibodies specific for said antigen and samples from an individual suspected of having Alzheimer's disease.