Peter J Hanson

US Patent:

6791688, Sep 14, 2004

Filed:

Apr 19, 2002

Appl. No.:

10/126916

Inventors:

Chee Kong Lai - Littleton MA
Charles Cooney - Brookline MA
James C. Leung - Weston MA
David P. Hoult - Saint Petersburg FL
Peter Hanson - Canaan NY
G. K. Raju - Newton MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

G01N 2164

US Classification:

356417, 2504581

Abstract:

The invention provides systems and methods for analyzing mixtures and, particularly during processing of the mixtures. The invention provides systems and methods for analyzing mixtures and, particularly, for analyzing mixtures during processing. The methods and systems utilize fluorescence to non-invasively analyze one or more components of the mixture. The analysis may provide a variety of compositional information such as the chemical identity of components, the concentration of components, the uniformity of the mixture and other information. A number of different types of processing equipment can be configured to provide the analysis and, accordingly, the analysis may be performed during a number of processing operations. The system and methods are particularly useful in processing mixtures which are preferably homogeneous blends, such as pharmaceutical products.

US Patent:

20210315846, Oct 14, 2021

Filed:

Aug 23, 2019

Appl. No.:

17/269577

Inventors:

- Boston MA, US
Peter D. Hanson - Prides Crossing MA, US
Randall Stevens - Rockport MA, US

International Classification:

A61K 31/167
A61K 47/10
A61K 9/00
A61P 29/00
A61K 9/08
A61P 19/02
A61K 47/18
A61K 47/02
A61F 7/10

Abstract:

The invention provides methods and compositions for sequential dosing of capsaicin to treat knee joint pain in a patient, such as knee joint pain due to osteoarthritis, while minimizing transient burning sensation experienced by patients due to capsaicin administration.

US Patent:

20210299072, Sep 30, 2021

Filed:

Jun 4, 2021

Appl. No.:

17/339414

Inventors:

- Boston MA, US
Peter D. Hanson - Prides Crossing MA, US
Randall Stevens - Rockport MA, US

International Classification:

A61K 31/167
A61P 19/02
A61F 7/10
A61K 9/00

Abstract:

The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.

US Patent:

20210145772, May 20, 2021

Filed:

Jul 24, 2020

Appl. No.:

16/937810

Inventors:

- Boston MA, US
Peter D. Hanson - Prides Crossing MA, US

International Classification:

A61K 31/165
A61P 17/00
A61K 9/00

Abstract:

The invention provides methods for treating acral lick granuloma in a canine using a capsaicinoid, such as capsaicin. The invention also provides methods for deactivating a nerve fiber selected from the group consisting of a C-fiber and an A-delta fiber, each being located in or proximal to an acral lick granuloma in a canine, using a capsaicinoid, such as capsaicin.

US Patent:

20200360314, Nov 19, 2020

Filed:

Aug 4, 2020

Appl. No.:

16/984384

Inventors:

- Boston MA, US
Peter D. Hanson - Prides Crossing MA, US
Randall Stevens - Rockport MA, US

International Classification:

A61K 31/167
A61P 19/02
A61F 7/10
A61K 9/00

Abstract:

The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.

US Patent:

20200297670, Sep 24, 2020

Filed:

Jan 24, 2020

Appl. No.:

16/751844

Inventors:

- Boston MA, US
Peter D. Hanson - Prides Crossing MA, US
Randall Stevens - Rockport MA, US

International Classification:

A61K 31/165
A61P 29/02
A61K 9/00
A61K 47/10

Abstract:

A method of ameliorating pain for a duration of at least 3 months due to an intermetatarsal neuroma in a patient, comprising administering by injection into or adjacent to the patient's intermetatarsal space having an intermetatarsal neuroma at least a first dose of capsaicin and a second dose of capsaicin, no sooner than one month after the first dose, to ameliorate pain due to the intermetatarsal neuroma.