Peter A Jensen

US Patent:

6953666, Oct 11, 2005

Filed:

Nov 5, 1999

Appl. No.:

09/831123

Inventors:

Raymond Shapira - Atlanta GA, US
Peter E. Jensen - Atlanta GA, US
Ngoc-Anh Le - Decatur GA, US
Jan Pohl - Tucker GA, US
W. Virgil Brown - Atlanta GA, US

Assignee:

Emory University - Atlanta GA

International Classification:

G01N033/53
A61K039/395

US Classification:

435 71, 436512, 435326, 4241301, 5303871, 5303891

Abstract:

This invention related generally to methods of detecting and quantifying biomarkers of oxidative stress in proteins. The biomarker may be any amino acid that has undergone oxidation (or other modification, e. g. chloro-tyrosine, dityrosine). Emphasis is given herein on oxidized sulfur- or selenium-containing amino acids (SSAA). The biomarker of oxidative stress in proteins may be detected with an antibody that binds to oxidized amino acids, specifically oxidized sulfur- or selenium-containing amino acids. The antibody may be monoclonal or polyclonal. The presence of biomarker or amount of biomarker present in a sample may be used to aid in assessing the efficacy of environmental, nutritional and therapeutic interventions, among other uses.