Peter I Levine

US Patent:

6925389, Aug 2, 2005

Filed:

Jul 18, 2001

Appl. No.:

09/906661

Inventors:

Ben A. Hitt - Severn MD, US
Peter J. Levine - Potomac MD, US
Lance A. Liotta - Bethesda MD, US

Assignee:

Correlogic Systems, Inc., - Bethesda MD
The United States of America as Represented by the Department of Health and Human Services - Washington DC

International Classification:

G01N033/48
G01N033/50
G06F007/00
G06G007/48

US Classification:

702 19, 702 20, 702 22, 702 27, 702 30, 702 32, 707 3, 707102, 435 6, 435 71

Abstract:

The invention describes a process for determining a biological state through the discovery and analysis of hidden or non-obvious, discriminatory biological data patterns. The biological data can be from health data, clinical data, or from a biological sample, (e. g. , a biological sample from a human, e. g. , serum, blood, saliva, plasma, nipple aspirants, synovial fluids, cerebrospinal fluids, sweat, urine, fecal matter, tears, bronchial lavage, swabbings, needle aspirantas, semen, vaginal fluids, pre-ejaculate. ), etc. which is analyzed to determine the biological state of the donor. The biological state can be a pathologic diagnosis, toxicity state, efficacy of a drug, prognosis of a disease, etc. Specifically, the invention concerns processes that discover hidden discriminatory biological data patterns (e. g. , patterns of protein expression in a serum sample that classify the biological state of an organ) that describe biological states.

US Patent:

7333895, Feb 19, 2008

Filed:

Jul 28, 2003

Appl. No.:

10/628135

Inventors:

Ben A. Hitt - Gaithersburg MD, US
Peter J. Levine - Potomac MD, US
Timothy A. Coleman - Derwood MD, US

Assignee:

Correlogic Systems, Inc. - Rockville MD

International Classification:

G06F 19/00

US Classification:

702 19

Abstract:

The invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method permits monitoring of an entire system for obtaining spectral data from biological samples. Generally, the method includes generating a bioassay process model, comparing a test sample against the bioassay process model. The bioassay process model may be based on the position of a centroid in n-dimensional space. The comparing may include comparing the location of a centroid associated with the test model against the centroid associated with the control model to determine the distance between the two centroids. By generating a trend plot of the distance between the centroid associated with the test sample and the centroid associated with the control model, overall system performance may be monitored over time.

US Patent:

7333896, Feb 19, 2008

Filed:

Jul 28, 2003

Appl. No.:

10/628137

Inventors:

Ben A. Hitt - Gaithersburg MD, US
Peter J. Levine - Potomac MD, US

Assignee:

Correlogic Systems, Inc. - Rockville MD
The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

G06F 19/00
G01N 24/00

US Classification:

702 19, 436173

Abstract:

The present invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method includes generating a bioassay process model, and then comparing spectral data based on a combination of a biochip and a test serum to the bioassay process model to determine if the test sample and the bioassay process are producing acceptable data. Alternatively, the method may include comparing spectral data based on a combination of serum and diluents used in an electrospray process to the bioassay process model. If the bioassay process and test sample fall within the model, then the spectrum produced may be further analyzed.

US Patent:

7395160, Jul 1, 2008

Filed:

Jul 28, 2003

Appl. No.:

10/628136

Inventors:

Ben A. Hitt - Severn MD, US
Peter J. Levine - Potomac MD, US
Timothy A. Coleman - Derwood MD, US

Assignee:

Correlogic Systems, Inc. - Bethesda MD

International Classification:

G06F 19/00
G01N 24/00

US Classification:

702 19, 436173

Abstract:

The present invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method includes generating a bioassay process model, and then comparing spectral data based on a combination of a biochip and a test serum to the bioassay process model to determine if the test sample and the bioassay process are producing acceptable data. Alternatively, the method may include comparing spectral data based on a combination of serum and diluents used in an electrospray process to the bioassay process model. If the bioassay process and test sample fall within the model, then the spectrum produced may be further analyzed.

US Patent:

20050260671, Nov 24, 2005

Filed:

Jul 27, 2005

Appl. No.:

11/189808

Inventors:

Ben Hitt - Severn MD, US
Peter Levine - Potomac MD, US
Emanuel Petricoin - Dunkirk MD, US
Lance Liotta - Bethesda MD, US

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50

US Classification:

435006000, 702019000

Abstract:

The invention describes a process for determining a biological state through the discovery and analysis of hidden or non-obvious, discriminatory biological data patterns. The biological data can be from health data, clinical data, or from a biological sample, (e.g., a biological sample from a human, e.g., serum, blood, saliva, plasma, nipple aspirants, synovial fluids, cerebrospinal fluids, sweat, urine, fecal matter, tears, bronchial lavage, swabbings, needle aspirantas, semen, vaginal fluids, pre-ejaculate.), etc. which is analyzed to determine the biological state of the donor. The biological state can be a pathologic diagnosis, toxicity state, efficacy of a drug, prognosis of a disease, etc. Specifically, the invention concerns processes that discover hidden discriminatory biological data patterns (e.g., patterns of protein expression in a serum sample that classify the biological state of an organ) that describe biological states.

US Patent:

20080103063, May 1, 2008

Filed:

Jan 2, 2008

Appl. No.:

11/968262

Inventors:

Ben Hitt - Gaithersburg MD, US
Peter Levine - Potomac MD, US
Emanuel Petricoin - Dunkirk MD, US

International Classification:

C40B 50/02

US Classification:

506024000

Abstract:

The present invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method includes generating a bioassay process model, and then comparing spectral data based on a combination of a biochip and a test serum to the bioassay process model to determine if the test sample and the bioassay process are producing acceptable data. Alternatively, the method may include comparing spectral data based on a combination of serum and diluents used in an electrospray process to the bioassay process model. If the bioassay process and test sample fall within the model, then the spectrum produced may be further analyzed.

US Patent:

20080195323, Aug 14, 2008

Filed:

Jan 2, 2008

Appl. No.:

11/968260

Inventors:

Ben A. Hitt - Gaithersburg MD, US
Peter J. Levine - Potomac MD, US
Timothy A. Coleman - Derwood MD, US

International Classification:

G01N 33/48

US Classification:

702 19

Abstract:

The invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method permits monitoring of an entire system for obtaining spectral data from biological samples. Generally, the method includes generating a bioassay process model, comparing a test sample against the bioassay process model. The bioassay process model may be based on the position of a centroid in n-dimensional space. The comparing may include comparing the location of a centroid associated with the test model against the centroid associated with the control model to determine the distance between the two centroids. By generating a trend plot of the distance between the centroid associated with the test sample and the centroid associated with the control model, overall system performance may be monitored over time.