Peter C Simpson

US Patent:

6623613, Sep 23, 2003

Filed:

Oct 2, 2000

Appl. No.:

09/678351

Inventors:

Richard A. Mathies - Moraga CA
Charles A. Emrich - Berkeley CA
Peter C. Simpson - Mountain View CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

B01D 5702

US Classification:

204453, 204450, 204600

Abstract:

A microfabricated liquid sample loading system comprising a first plate having an array of microfabricated holes passing therethrough; a second plate positioned against the first plate, the second plate having an array of microfabricated holes passing therethrough; and a plurality of microfabricated channels disposed on a surface of at least one of the first or second plates, the microfabricated channels connecting the array of microfabricated holes in the first plate with the array of microfabricated holes in the second plate.

US Patent:

6749734, Jun 15, 2004

Filed:

Aug 28, 2000

Appl. No.:

09/649272

Inventors:

Peter C. Simpson - Oakland CA
Richard A. Mathies - Moraga CA
Adam T. Woolley - Belmont MA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

B01D 5702

US Classification:

204547, 204450, 204600, 204453

Abstract:

A capillary array electrophoresis (CAE) micro-plate with an array of separation channels connected to an array of sample reservoirs on the plate. The sample reservoirs are organized into one or more sample injectors. One or more waste reservoirs are provided to collect wastes from reservoirs in each of the sample injectors. Additionally, a cathode reservoir is also multiplexed with one or more separation channels. To complete the electrical path, an anode reservoir which is common to some or all separation channels is also provided on the micro-plate. Moreover, the channel layout keeps the distance from the anode to each of the cathodes approximately constant.

US Patent:

6913679, Jul 5, 2005

Filed:

Feb 11, 1999

Appl. No.:

09/249274

Inventors:

Richard A. Mathies - Moraga CA, US
Brian Paegel - Berkeley CA, US
Peter C. Simpson - Oakland CA, US
Lester Hutt - Berkeley CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N027/447
G01N027/453
G01N030/02
B01L003/02

US Classification:

204451, 204601, 422 70, 422 99

Abstract:

Sample component separation apparatus and methods are described. An exemplary sample component separation apparatus includes a separation channel having a turn portion configured to reduce band-broadening caused by passage of a sample through the turn portion. To reduce band broadening caused by passage of a sample through a turn portion, the turn portion may be constructed and arranged to have a sample transport characteristic that is different from the corresponding sample transport characteristic of a substantially straight portion of the separation channel. For example, the turn portion may be configured with an effective channel width that is smaller than the effective channel widths of the substantially straight portion of the separation channel. The actual channel width of the turn portion may be smaller than the channel widths of the substantially straight portion; the effective channel width of the turn portion may be reduced by placing one or more sample transport barriers or constrictions in the turn portion of the channel. Alternatively, the sample velocity through the turn portion may be controlled so as to reduce band broadening.

US Patent:

7074307, Jul 11, 2006

Filed:

Jul 21, 2004

Appl. No.:

10/897312

Inventors:

Peter C. Simpson - Del Mar CA, US
James R. Petisce - San Diego CA, US
Victoria Carr-Brendel - Pleasanton CA, US
James H. Brauker - San Diego CA, US

Assignee:

DexCom, Inc. - San Diego CA

International Classification:

G01N 27/327
A61B 5/05

US Classification:

20440304, 2044031, 20440311, 600345, 600347

Abstract:

The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.

US Patent:

7081195, Jul 25, 2006

Filed:

Dec 7, 2004

Appl. No.:

11/007635

Inventors:

Peter Simpson - Del Mar CA, US
James Brauker - San Diego CA, US
Victoria Carr-Brendel - Pleasanton CA, US
Paul Goode - Cherry Hill NJ, US
Mark Tapsak - Orangeville PA, US

Assignee:

DexCom, inc. - San Diego CA

International Classification:

G01N 27/327

US Classification:

2057775, 205792, 20440301, 20440311

Abstract:

An analyte-measuring device, particularly an electrochemical sensor, is provided for measuring current values at multiple bias potential settings to assess the quality of the analyte measurement, identify interference in the signal, and calculate substantially interference-free analyte concentration measurements. The device and method are suitable for calculating substantially interference-free analyte concentration measurements when glucose is the analyte and acetaminophen is an interfering species.

US Patent:

7108778, Sep 19, 2006

Filed:

Jul 21, 2004

Appl. No.:

10/897377

Inventors:

Peter C. Simpson - Del Mar CA, US
Paul Goode - Murrieta CA, US
Mark A. Tapsak - Orangeville PA, US
Victoria Carr-Brendel - Pleasanton CA, US

Assignee:

DexCom, Inc. - San Diego CA

International Classification:

G01N 27/327

US Classification:

205778, 2057775, 2044031, 20440309, 20440314

Abstract:

The present invention relates generally to systems and methods for increasing oxygen generation in electrochemical sensors in order to overcome the oxygen limitations. The preferred embodiments employ electrode systems with at least two electrodes in relatively close proximity to each other; wherein at least one electrode is configured to generate oxygen and at least one other electrode is configured to sense an analyte or a product of a reaction indicative of the concentration of analyte. The oxygen generated by the oxygen-generating electrode is available to the catalyst within a membrane system and/or the counter electrode, thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions.

US Patent:

7364592, Apr 29, 2008

Filed:

Feb 9, 2005

Appl. No.:

11/055779

Inventors:

Victoria Carr-Brendel - San Diego CA, US
Peter C. Simpson - Del Mar CA, US
James H. Brauker - San Diego CA, US

Assignee:

DexCom, Inc. - San Diego CA

International Classification:

A61F 2/02

US Classification:

623 2376, 424424

Abstract:

Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture. The macro- and micro-architectures work together to manage and manipulate the high-level tissue organization and the low-level cellular organization of the foreign body response in vivo, thereby increasing neovascularization close to a device-tissue interface, interfering with barrier cell layer formation, and providing good tissue anchoring, while reducing the effects of motion artifact, and disrupting the organization and/or contracture of the FBC. The biointerface membranes of the preferred embodiments can be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample (for example, from a body), cell transplantation devices, drug delivery devices, electrical signal delivering or measuring devices, and/or combinations thereof.

US Patent:

7366556, Apr 29, 2008

Filed:

Oct 4, 2006

Appl. No.:

11/543683

Inventors:

Mark Brister - Encinitas CA, US
James R. Petisce - San Diego CA, US
Peter Simpson - Encinitas CA, US

Assignee:

DexCom, Inc. - San Diego CA

International Classification:

A61B 5/00
A61B 5/05

US Classification:

600347, 600365, 600345

Abstract:

Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.