Peter H Tran

US Patent:

20210236784, Aug 5, 2021

Filed:

Apr 19, 2021

Appl. No.:

17/233654

Inventors:

- Boston MA, US
Colin Robert GARDNER - Concord MA, US
Thomas H. JOZEFIAK - Belmont MA, US
Christopher R. LOOSE - Cambridge MA, US
David LUCCHINO - Charlestown MA, US
Andrew Craig MILLER - East Walpole MA, US
Carlo Giovanni TRAVERSO - Newton MA, US
Ayush VERMA - Newton MA, US
Arthur J. COURY - Boston MA, US
Peter TRAN - Tampa FL, US
John JANTZ - Arlington MA, US

International Classification:

A61M 31/00
A61K 9/70
A61K 9/00

Abstract:

A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20 C. in phosphate buffered saline at pH 6.5.

US Patent:

20200384250, Dec 10, 2020

Filed:

Jul 31, 2020

Appl. No.:

16/944955

Inventors:

- Boston MA, US
Colin Robert GARDNER - Concord MA, US
Thomas H. JOZEFIAK - Belmont MA, US
Christopher R. LOOSE - Cambridge MA, US
David LUCCHINO - Charlestown MA, US
Andrew Craig MILLER - East Walpole MA, US
Carlo Giovanni TRAVERSO - Newton MA, US
Ayush VERMA - Newton MA, US
Arthur J. COURY - Boston MA, US
Peter TRAN - Tampa FL, US
John JANTZ - Arlington MA, US

International Classification:

A61M 31/00
A61K 9/70
A61K 9/00

Abstract:

A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20 C. in phosphate buffered saline at pH 6.5.

US Patent:

20200030242, Jan 30, 2020

Filed:

Feb 3, 2017

Appl. No.:

16/071961

Inventors:

- Boston MA, US
John JANTZ - Arlington MA, US
Peter TRAN - Tampa FL, US
Rachel SHAPIRO - Yorktown NY, US
Nicholas PILLA - Boston MA, US
Jules JACOB - Yardley PA, US
Braden KUO - Newton MA, US
Colin Rober GARDNER - Concord MA, US
Padmaja SHIVANAND - Seattle WA, US
Jacob BARLOW - Boston MA, US
Lisa Viana FERREIRA - Franklin MA, US

International Classification:

A61K 9/20
A61K 9/28
A61K 9/50

Abstract:

A pharmaceutically acceptable oral dosage form for delivery of an agent to an intestinal site has one or more active agent regions having an active agent to be delivered to the intestinal site, one or more drying agent regions having at least one drying agent therein capable of drying an area about the intestinal site, the one or more drying agent regions being separate from the one or more active agent regions, and a protective coating at least partially covering a surface of the form. The dosage form has a fluid uptake capacity as measured for the entire dosage form when immersed in a fluid media according to a Dosage Form Fluid Uptake Assay of at least about 20 g fluid per dosage form.

US Patent:

20180193621, Jul 12, 2018

Filed:

Jun 28, 2016

Appl. No.:

15/740144

Inventors:

- BOSTON MA, US
Colin R. Gardner - Concord MA, US
Thomas H. Jozefiak - Belmont MA, US
Christopher R. Loose - Cambridge MA, US
David Lucchino - Charlestown MA, US
Andrew Craig Miller - East Walpole MA, US
Carlo Giovanni Traverso - Newton MA, US
Ayush Verma - Newton MA, US
Arthur J. Coury - Boston MA, US
Peter Tran - Tampa FL, US
John Jantz - Arlington MA, US

International Classification:

A61M 31/00
A61K 9/00

Abstract:

A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20 C. in phosphate buffered saline at pH 6.5.