Peter K Tsang

US Patent:

8036835, Oct 11, 2011

Filed:

Jun 9, 2010

Appl. No.:

12/797521

Inventors:

Nicholas M. Sampas - San Francisco CA, US
Bo Curry - Redwood City CA, US
Peter Tsang - San Francisco CA, US
Doron Lipson - Tel-Aviv, IL
Zohar H. Yakhini - Ramat Hasharon, IL

Assignee:

Agilent Technologies, Inc. - Santa Clara CA

International Classification:

G06F 7/00

US Classification:

702 19, 702 20, 703 11, 703 12, 707700

Abstract:

Methods and systems for identifying and selecting nucleic acid probes for detecting a target with a nucleic acid probe array or comparative genome hybridization microarray, comprising selecting a plurality of potential target sequences, generating a plurality of candidate probes from the target sequences, filtering the plurality of candidate probes by analyzing candidate probes for selected probe properties in silico. Microarrays comprising probes selected by the methods of the invention are particularly useful for comparative genome hybridization and location analysis.

US Patent:

20030027219, Feb 6, 2003

Filed:

Jul 31, 2001

Appl. No.:

09/919643

Inventors:

Diane Ilsley - San Jose CA, US
Douglas Amorese - Los Altos CA, US
Michael Caren - Palo Alto CA, US
Peter Tsang - San Francisco CA, US

International Classification:

G01N033/53
G01N033/542
B05D001/32

US Classification:

435/007900, 427/466000

Abstract:

Methods for efficiently depositing small quantities of a protein containing fluid onto the surface of a substrate are provided. A feature of the subject methods is that the deposition process does not substantially modulate the protein activity/functionality of the deposited fluid. In practicing the subject methods, a small volume of fluid containing the protein(s) of interest is front loaded into a thermal inkjet device. Next, a small quantity of the front loaded fluid is expelled onto the surface of a substrate. The subject methods find use in a variety of different applications where the deposition of small volumes of a fluid containing a protein of interest is desired.

US Patent:

20060110744, May 25, 2006

Filed:

Nov 23, 2004

Appl. No.:

10/996323

Inventors:

Nicolas Sampas - San Jose CA, US
Bo Curry - Redwood City CA, US
Peter Tsang - San Francisco CA, US
Doron Lipson - Tel-Aviv, IL
Zohar Yakhini - Romat Hasharon, IL

International Classification:

C12Q 1/68
G06F 19/00
C12M 1/34

US Classification:

435006000, 435287200, 702020000

Abstract:

Methods and systems for identifying and selecting nucleic acid probes for detecting a target with a nucleic acid probe array or comparative genome hybridization microarray, comprising selecting a plurality of potential target sequences, generating a plurality of candidate probes from the target sequences, filtering the plurality of candidate probes by analyzing candidate probes for selected probe properties in silico. Microarrays comprising probes selected by the methods of the invention are particularly useful for comparative genome hybridization and location analysis.

US Patent:

20070037201, Feb 15, 2007

Filed:

Oct 13, 2006

Appl. No.:

11/580583

Inventors:

Nicholas Sampas - San Jose CA, US
Peter Tsang - San Francisco CA, US
Brian Giles - Fremont CA, US

International Classification:

C12Q 1/68
G06F 19/00

US Classification:

435006000, 702020000

Abstract:

Methods and systems for selecting oligonucleotide probes for use in microarray applications are provided herein. The described methods use a combination of measured probe performance and predicted probe performance to select probes. Nucleic acid arrays containing probes selected by the described methods are described. Also included are algorithms for performing the subject methods recorded on computer-readable media and computational systems for analysis.

US Patent:

20100221708, Sep 2, 2010

Filed:

Mar 2, 2009

Appl. No.:

12/396308

Inventors:

N. Alice Yamada - San Jose CA, US
Peter Tsang - San Francisco CA, US
Robert A. Ach - San Francisco CA, US
Amir Ben-Dor - Kfar Kava, IL

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

A method of sample analysis is provided. The method comprises: a) contacting a genomic sample comprising a plurality of intact chromosomes, i.e., metaphase or interphase chromosomes, with a first set of labeled oligonucleotide probes under in situ hybridization conditions to produce a contacted sample comprising labeled chromosomes, where i. each of the labeled oligonucleotide probes is complementary to a non-repetitive, unique sequence in a region that flanks the centromere of a single chromosome of the plurality of chromosomes; and ii. hybridization of the labeled oligonucleotide probes to the chromosomes produces a distinct labeling pattern for each hybridized chromosome, thereby allowing each of the labeled chromosomes to be distinguished from one another; b) imaging the hybridized chromosomes to provide an image showing the labeling pattern for each labeled chromosome; and c) enumerating a labeled chromosome based on the labeling pattern of said labeled chromosome. A composition and kits for performing the method are also provided.

US Patent:

46668349, May 19, 1987

Filed:

Mar 28, 1984

Appl. No.:

6/594231

Inventors:

Julius G. Bekesi - Teaneck NJ
James F. Holland - Scarsdale NY
Peter H. Tsang - New York NY

Assignee:

Mount Sinai School of Medicine of the City University of New York - New York NY

International Classification:

C12Q 102
G01N 33534

US Classification:

435 29

Abstract:

A new technique is disclosed for assaying for the presence of invasive cancer. While based on leukocyte adherence inhibition, it is improved by using relatively long lived radio-labeled leukocytes, fractionation of the leukocytes to separately treat T-cells and monocytes and by providing for human plasma or serum in the incubation medium.

US Patent:

44553790, Jun 19, 1984

Filed:

Jul 21, 1981

Appl. No.:

6/285587

Inventors:

Julius G. Bekesi - Teaneck NJ
James F. Holland - Scarsdale NY
Peter H. Tsang - New York NY

Assignee:

Mount Sinai School of Medicine of the City University of New York - New York NY

International Classification:

G01N 3358
G01N 3360

US Classification:

436504

Abstract:

A new technique is disclosed for assaying for the presence of invasive cancer. While based on leukocyte adherence inhibition, it is improved by using relatively long lived radio-labeled leukocytes, fractionation of the leukocytes to separately treat T-cells and monocytes and by providing for human plasma or serum in the incubation medium.