Philip L Edwards

Address:

3347 S Cheekwood Ln, Bloomington, IN 47401

Phone:

4849495948

VIN:

3VWRJ71K49M042546

Make:

VOLKSWAGEN

Model:

JETTA

Year:

2009

US Patent:

7342022, Mar 11, 2008

Filed:

Dec 18, 2002

Appl. No.:

10/499388

Inventors:

Stefan Berg - Södertälje, SE
Ratan Bhat - Södertälje, SE
Philip Edwards - Wilmington DE, US
Sven Hellberg - Södertälje, SE

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

A61K 31/55
A61K 31/517
C07D 401/14
C07D 403/04
C07D 403/14
A61P 3/08
A61P 25/28
C07D 209/34

US Classification:

5142662, 51421208, 544284, 540524

Abstract:

The present invention relates to new compounds of formula I wherein R, R, R, n, m are defined as in claim 1, a process for their preparation and new intermediates used in the preparation thereof, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy, especially in the prevention and/or treatment of dementia related diseases, Alzheimer's Disease and conditions associated with glycogen synthase kinase-3.

US Patent:

20050070559, Mar 31, 2005

Filed:

Dec 18, 2002

Appl. No.:

10/499950

Inventors:

Stefan Berg - Sodertalje, SE
Ratan Bhat - Sodertalje, SE
Philip Edwards - Wilmington DE, US
Sven Hellberg - Sodertalje, SE

International Classification:

A61K031/517
C07D043/04

US Classification:

514266200, 544284000

Abstract:

The present invention relates to a new use of oxindole derivatives of formula I, as a free base or a pharmaceutically acceptable salt thereof, wherein R, R, R, m and n arm as defined as in claim 1, as well as to new compounds, a process for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds in therapy, especially in the prevention and/or treatment of dementia related diseases, Alzheimer's Disease and conditions associated with glycogen synthase kinase-3.

US Patent:

20090312322, Dec 17, 2009

Filed:

Dec 9, 2008

Appl. No.:

12/330834

Inventors:

Stefan Berg - Sodertalje, SE
Ratan Bhat - Sodertalje, SE
Philip Edwards - Wilmington DE, US
Sven Hellberg - Sodertalje, SE

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

A61K 31/5377
C07D 413/14
C07D 413/02
C07D 403/02
A61K 31/517
A61P 25/00

US Classification:

5142345, 544116, 544284, 5142662

Abstract:

The present invention relates to a new use of oxindole derivatives of formula I, as a free base or a pharmaceutically acceptable salt thereof, [Chemical formula should be inserted here. Please see paper copy.] wherein R, R, R, m and n are as defined as in claim , as well as to new compounds, a process for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds in therapy, especially in the prevention and/or treatment of dementia related diseases, Alzheimer's Disease and conditions associated with glycogen synthase kinase-3.

US Patent:

51945886, Mar 16, 1993

Filed:

Mar 9, 1990

Appl. No.:

7/491757

Inventors:

Philip D. Edwards - Claymont DE
John A. Schwartz - Wilmington DE
Mark M. Stein - Wilmington DE
Diane A. Trainor - Glen Mills PA
Richard A. Wildonger - Newark DE

Assignee:

ICI Americas Inc. - Wilmington DE

International Classification:

A61K 3702
C07K 506
C07K 508
C07K 510

US Classification:

530331

Abstract:

The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.

US Patent:

50554506, Oct 8, 1991

Filed:

Mar 13, 1990

Appl. No.:

7/493025

Inventors:

Philip D. Edwards - Claymont DE
John A. Schwartz - Wilmington, all DE
Mark M. Stein - Wilmington, all DE
Diane A. Trainor - Glen Mills PA
Richard A. Wildonger - Elmwood DE

Assignee:

ICI Americas Inc. - Wilmington DE

International Classification:

A61K 3764

US Classification:

514019

Abstract:

The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.

US Patent:

55323669, Jul 2, 1996

Filed:

Jan 19, 1995

Appl. No.:

8/375201

Inventors:

Philip D. Edwards - Kennett Square PA
Peter Warner - Macclesfield, GB
Donald J. Wolanin - Orange CT

Assignee:

Zeneca Limited - London

International Classification:

A61K 31505
C07D47104

US Classification:

5142342

Abstract:

The present invention relates to certain novel amide derivatives which are pyrido[3,4-d]pyrimidin-7-ylacetamides which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these amide derivatives, processes for preparing the amide derivatives, pharmaceutical compositions containing such amide derivatives and methods for their use.

US Patent:

51643715, Nov 17, 1992

Filed:

May 11, 1988

Appl. No.:

7/193317

Inventors:

Philip D. Edwards - Claymont DE
Joseph J. Lewis - West Chester PA
Charles W. Perkins - Wilmington DE
Diane A. Trainor - Glen Mills PA
Richard A. Wildonger - Morgan Hollow PA

Assignee:

ICI Americas Inc. - Wilmington DE

International Classification:

C07D23708
C07D23906
C07K 508
A61K 3702

US Classification:

514 18

Abstract:

The invention provides a series of novel heterocyclic ketones of formula I ##STR1## and pharmaceutically acceptable base-addition salts thereof, in which the values of R. sup. 4, L, A, X and Q have the meanings defined in the following specification. The compounds of formula I are inhibitors of human leukocytic elastase. The invention also provides pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable base-addition salt thereof, and processes and intermediates for the manufacture of compounds of formula I.

US Patent:

54419603, Aug 15, 1995

Filed:

Apr 8, 1993

Appl. No.:

8/044866

Inventors:

Peter R. Bernstein - Wallingford PA
Philip D. Edwards - Kennett Square PA
Andrew Shaw - Kennett Square PA
Royston M. Thomas - Macclesfield, GB2
Chris A. Veale - Newark DE
Peter Warner - Macclesfield CT
Donald J. Wolanin - Orange CT

Assignee:

Zeneca Limited - London

International Classification:

A61K 31505
C07D23922

US Classification:

514269

Abstract:

The present invention relates to certain novel substituted ketones which are 1-pyrimidinylacetamide derivatives of formula I, ##STR1## set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates ##STR2## useful in the synthesis of these substituted ketones processes for preparing the substituted ketones pharmaceutical compositions containing such substituted ketones and methods for their use.