Philip A Garner

US Patent:

7183394, Feb 27, 2007

Filed:

Aug 11, 2000

Appl. No.:

10/110017

Inventors:

Philip P. Garner - Cleveland Heights OH, US

International Classification:

C07H 21/02
C07H 21/04
C07H 21/00
C12Q 1/68

US Classification:

536 231, 536 243, 536 253, 435 6

Abstract:

The present invention relates to peptide-based nucleic acid surrogates (PNAs) having a repeating structure of (AA-aa)and a particular secondary structure that can bind to particular single-stranded nucleic acid targets. Preferably the peptide-based nucleic acid surrogate has an alpha-helical secondary structure (αPNA). Also, the present invention relates to the method of forming peptide-based nucleic acid surrogates having a particular secondary structure. The nucleic acid surrogates may be utilized for therapeutic (antisense, antigene), diagnostic (genetic), and molecular switching (αPNA chips) applications.

US Patent:

57314160, Mar 24, 1998

Filed:

May 14, 1996

Appl. No.:

8/645930

Inventors:

Philip P. Garner - Cleveland Heights OH

Assignee:

Case Western Reserve University - Cleveland OH

International Classification:

C07K 200
A61K 3802

US Classification:

530350

Abstract:

The present invention relates to the development of a new class of oligonucleotide surrogates capable of sequence specific binding to simple stranded DNA and RNA as well as to double stranded DNA targets. More specifically, structures (Ser/Thr�CH. sub. 2 B!-AA). sub. n represent the repeating structural units for a number of the nucleic acid surrogates of the present invention. Once synthesized (in suitably protected form), the monobasic units are linked together via peptide bonds to produce the required oligomeric structures having defined nucleobase sequences. These nucleic acid surrogates may then be utilized for use as antisense/antigene probes and/or drug carriers.