Phillip M Cook

US Patent:

7323449, Jan 29, 2008

Filed:

Jul 18, 2003

Appl. No.:

10/520925

Inventors:

David B. Olsen - Lansdale PA, US
Balkrishen Bhat - Carlsbad CA, US
Phillip Dan Cook - Fallbrook CA, US

Assignee:

Merck & Co., Inc. - Rahway NJ
Isis Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07D 487/04
A61K 31/52
A61K 31/675
C07F 9/6561
A61P 31/14

US Classification:

514 43, 514244, 514280, 514 81, 5142651, 514 52, 536 267, 536 272

Abstract:

The present invention provides thionucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such thionucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the thionucleoside compounds of the present invention.

US Patent:

49084410, Mar 13, 1990

Filed:

Jul 19, 1988

Appl. No.:

7/221478

Inventors:

Phillip D. Cook - Downingtown PA
Dennis J. McNamara - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07H 19173
C07H 1920

US Classification:

536 27

Abstract:

3'-Acyl-2-chloro-2'-deoxy-5'-adenylic acids (I) as well as a method for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compound in dosage forms. The compounds of the invention have pharmacological properties and are useful antimicrobial agents and antitumor agents.