Phillip O Crews

US Patent:

6750247, Jun 15, 2004

Filed:

May 31, 2002

Appl. No.:

10/159772

Inventors:

Phillip Crews - Santa Cruz CA
Jennifer Carroll - Santa Cruz CA
Theodore Holman - Santa Cruz CA
Guy Miller - Santa Clara CA
Steve Bobzin - Santa Clara CA
Lesley Brown - Santa Clara CA

Assignee:

Galileo Laboratories, Inc. - Santa Clara CA

International Classification:

A61K 3119

US Classification:

514456, 514461, 514569, 549407, 549502

Abstract:

Compounds that are effective lipoxygenase inhibitors, and methods and pharmaceutical compositions for inhibiting lipoxygenases and for treatment of lipoxygenase-mediated conditions in humans and other subjects. The compounds, methods and pharmaceutical compositions utilize subersic terpenoids, jaspic terpenoids, igernellic terpenoids, hippospongic terpenoids, halicondric terpenoids, dictyodendric terpenoids, and/or heteronemic terpenoids, and synthetic derivatives or analogs thereof. Exemplary compounds include (-)-subersic acid, (+)-subersin, jaspaquinol, (-)-jaspic acid, igernellin, halisufate 7, and hipposulfate C and D, and derivatives thereof.

US Patent:

49435892, Jul 24, 1990

Filed:

Oct 27, 1988

Appl. No.:

7/263261

Inventors:

Phillip Crews - Santa Cruz CA
Thomas R. Matthews - Los Gatos CA
Paul Horton - Santa Cruz CA

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA
The Regents of the Univ. of California - Berkeley CA

International Classification:

A61K 3134
C07D40712

US Classification:

514468

Abstract:

This invention is directed to a method for treating helminthiasis which comprises administering to an animal in need thereof an anthelmintically effective amount of a compound of Formula (I): ##STR1## where R. sup. 1 is hydrogen or --SR. sup. 2, wherein R. sup. 2 is hydrogen, --C(O)--CH. sub. 3, or ##STR2## or a pharmaceutically acceptable salt thereof. This invention is also directed to a composition for treating helminthiasis in an animal which comprises a pharmaceutically acceptable excipient and an anthelmintically effective amount of a compound of Formula (I). This invention is also directed to novel compounds of Formula (I) wherein R. sup. 2 is ##STR3##.

US Patent:

56077416, Mar 4, 1997

Filed:

Dec 8, 1994

Appl. No.:

8/351624

Inventors:

Richard C. Zimmerman - Pacific Grove CA
Randall S. Alberte - Arlington VA
James S. Todd - Walla Walla WA
Phillip Crews - Santa Cruz CA

Assignee:

ARCH Development Corporation - Chicago IL
The Regents of the University of California - Oakland CA

International Classification:

B32B 904

US Classification:

428 68

Abstract:

p-Sulfoxy cinnamic acid isolated from methanolic extracts of the eelgrass Zostera marina having significant antifouling aquatic properties. p-Sulfoxy cinnamic acid was synthesized in the laboratory from p-coumaric acid, and antifouling activity was identical to the natural compound in laboratory bioassays. In addition, sulfate esters of other phenolic acids showed similar antifouling activity, suggesting that the sulfate ester was responsible for the antifouling effect.

US Patent:

53841760, Jan 24, 1995

Filed:

Dec 11, 1992

Appl. No.:

7/989274

Inventors:

Richard C. Zimmerman - Pacific Grove CA
Randall S. Alberte - Arlington VA
James S. Todd - Walla, Walla WA
Phillip Crews - Santa Cruz CA

International Classification:

B32B 904

US Classification:

428 68

Abstract:

p-sulfoxy cinnamic acid isolated from methanolic extracts of the eelgrass Zostera marina having significant antifouling aquatic properties. p-sulfoxy cinnamic acid was synthesized in the laboratory from p-coumaric acid, and antifouling activity was identical to the natural compound in laboratory bioassays. In addition, sulfate esters of other phenolic acids showed similar antifouling activity, suggesting that the sulfate ester was responsible for the antifouling effect.

US Patent:

20210221777, Jul 22, 2021

Filed:

Jan 14, 2021

Appl. No.:

17/149203

Inventors:

Tyler A. Johnson - San Rafael CA, US
Colon V. Cook - San Rafael CA, US
Nicole L. McIntosh - Novato CA, US
Joseph D. Morris - San Rafael CA, US
Frederick A. Valeriote - Grosse Pointe Shores MI, US
JiaJiu Shaw - Frisco TX, US
Phillip Crews - Santa Cruz CA, US
Mani Maheshwari - Farmington Hills MI, US

International Classification:

C07D 277/30
A61P 35/00

Abstract:

A pharmaceutically active mycathiozole analog or salt thereof is derived from naturally occurring mycathiozole. The analog or salt is useful in cancer treatment.