Phillip J Gibbs

US Patent:

7163815, Jan 16, 2007

Filed:

Jan 28, 2005

Appl. No.:

11/045874

Inventors:

Andreas Bommarius - Atlanta GA, US
Phillip Gibbs - Atlanta GA, US
William Wellborn - Marietta GA, US

Assignee:

Georgia Tech Research Corporation - Atlanta GA

International Classification:

C12N 9/04
C12N 9/54
C12N 1/20
C12P 7/22
C07H 21/06

US Classification:

435190, 435221, 435156, 435 691, 4352522, 536 232

Abstract:

The present invention is directed to compositions and methods comprising NAD(P)H oxidases, particularly bacterial oxidases, nucleic acids, recombinant plasmid vectors and recombinant proteins therein encoded, and host cells comprising the oxidases and nucleic acids. The present invention also comprises an isolated bacterial oxidase that oxidizes both NADH and NADPH. Methods for producing the enzymes and enzymatic reactions comprising use of NAD(P)H oxidases and products of such reactions are also disclosed.

US Patent:

7301633, Nov 27, 2007

Filed:

Oct 1, 2002

Appl. No.:

10/491094

Inventors:

Phillip Ray Gibbs - Atlanta GA, US
Rick P. Trebino - Atlanta GA, US
Andreas Sebastian Bommarius - Atlanta GA, US
Mark W. Kimmel - Lawrenceville GA, US

Assignee:

Georgia Institute of Technology - Atlanta GA

International Classification:

G01J 4/00

US Classification:

356369, 356367

Abstract:

A new generation polarimetry apparatus and methodology is disclosed, which involve passing polarized light through a sample including a chiral analyte, where the analyte is under the influence of a periodically varying magnetic field. The apparatus also utilizes optical heterodyne detection and lock-in detection at higher order harmonics of the magnetic field modulation frequency to improve sensitivity and detection limits of optical properties of chiral analytes.

US Patent:

7405826, Jul 29, 2008

Filed:

Jun 29, 2005

Appl. No.:

11/168295

Inventors:

Phillip R. Gibbs - Atlanta GA, US
Jason D. Beebe - Atlanta GA, US

International Classification:

G01N 21/00
G01J 4/00

US Classification:

356432, 356364, 356440, 356368

Abstract:

An apparatus and method for improved detection of a chiral property of a sample begins with a probe beam of light having a first modulation frequency ω and is further modulated with a second modulation frequency φ. A non-linear photo-detector, which may include multiple detector portions to form a balanced receiver, mixes the first modulation with the second modulation to analyze frequency components at inter-modulated sidebands, where the level of the inter-modulated sidebands are related to the chiroptical property of the sample. The inter-modulated sidebands may be the additive sidebands or the subtractive sidebands. A lock-in detector can be used to receive a signal output from the non-linear photo-detector and generate the modulation signals at the different modulating frequencies. Furthermore, the non-linear photo-detector may analyze a ratio of the inter-modulated sideband levels, such as (φ+2ω)/(φ+ω), to yield a signal that is linearly related to the chiral property of the sample.

US Patent:

7468788, Dec 23, 2008

Filed:

Jun 21, 2006

Appl. No.:

11/471994

Inventors:

Phillip R. Gibbs - Atlanta GA, US
John Wade - Alpharetta GA, US

Assignee:

Stheno Corporation - Atlanta GA

International Classification:

G01N 21/01
G01J 4/00

US Classification:

356244, 356245, 356364

Abstract:

Relating to chiral detection systems, various improvements are disclosed including an improved apparatus for detecting a chiral property of a sample. It has a rugged and stable optical rail that operates as a heat sink to the systems' elements and comprises a captive guide structure of heat conductive material having an elevated top platform and a dove tailed lip on the sides. The elevated top platform has a substantial width in comparison to a height of the elevated top platform. The apparatus further includes a wide base portion of heat conductive material supportive of the captive guide structure. The base has a width that is at least twice the width of the elevated top platform and a substantial thickness relative to the captive guide structure. Multiple system elements can be securely mounted on the captive guide structure with some elements being in thermal contact with the elevated top platform.

US Patent:

7502111, Mar 10, 2009

Filed:

Nov 24, 2004

Appl. No.:

10/995118

Inventors:

Phillip R. Gibbs - Atlanta GA, US

Assignee:

Stheno Corporation - Atlanta GA

International Classification:

G01J 4/00

US Classification:

356364

Abstract:

A differential method has been developed which determines displacement from the midpoint of optical transmission (45) and utilizes the coupled nature of the two signals for common mode noise rejection to enhance the detection of chiral species. A beam of light is modulated, applied to the chiral mixture, and then split into a first beam and a related orthogonal beam by a polarizer or prism. The first beam and orthogonal beam are converted into electrical signals before a differential comparison of the signals is performed to detect a desired chiral species within the chiral mixture.

US Patent:

7590196, Sep 15, 2009

Filed:

May 3, 2005

Appl. No.:

11/120723

Inventors:

Phillip R. Gibbs - Atlanta GA, US

International Classification:

H04L 27/06

US Classification:

375340, 375316, 375295

Abstract:

The present invention provides a method, circuit and system for phase-sensitive detection and recovery of complex signals of interest using a double reference lock-in detector. A double reference lock-in detector may have two or more reference signal sources whose signals are first combined, producing a composite (e. g. , inter-modulation) reference signal. This signal is then mixed with an input signal, yielding the desired selectivity at the frequency(ies) of interest. A second embodiment uses external reference signals, synchronizing internal references to these before combining the reference signals. Such detectors may used in chiral detection systems for recovering predetermined signals of interest associated with chiral properties of a sample being tested.

US Patent:

20060001509, Jan 5, 2006

Filed:

Jun 29, 2005

Appl. No.:

11/168296

Inventors:

Phillip Gibbs - Atlanta GA, US

International Classification:

H01P 1/20

US Classification:

333202000, 333186000, 424009100, 702085000, 073001010

Abstract:

An apparatus and method for automatically tuning a resonant circuit in a chiroptical measurement system. A sample cell holds a sample being measured for a chiroptical property as the sample is modulated by the resonant circuit. A signal source coupled to the resonant circuit generates a driving signal at one of a plurality of frequencies to modulate the resonant circuit. The frequencies are within a range of expected resonant frequencies for the resonant circuit. A feedback loop circuit coupled to the signal source is used to adjust the frequency of the driving signal to another of the frequencies in response to a feedback signal associated with a measured parameter of the driving signal. In this way, the frequency of the driving signal is adjusted to create a resonant condition. The driving signal may also be applied at a reduced power level so that the resonant circuit can be driven at off-resonant frequencies within the range of frequencies.

US Patent:

20120282655, Nov 8, 2012

Filed:

May 4, 2012

Appl. No.:

13/464317

Inventors:

Phillip R. Gibbs - Atlanta GA, US

Assignee:

Renmatix, Inc. - Kennesaw GA

International Classification:

C07H 1/08
C07C 27/00
C07C 51/00
C12P 7/16
C07H 3/02
C07H 3/06
C12P 19/00
C12P 7/10
C07C 29/00
C07D 307/50

US Classification:

435 72, 568902, 536124, 562607, 549489, 536 111, 536127, 127 36, 435165, 435160

Abstract:

Methods are disclosed for increasing the level of soluble Csaccharides produced from lignocellulosic biomass comprising acidifying fractionated lignocellulosic biomass to prevent the recondensation of soluble Csaccharides, including Coligosaccharides and xylose and arabinose monomers, to insoluble higher molecular weight Coligosaccharides.