Phillips W Robbins

US Patent:

20100120701, May 13, 2010

Filed:

Sep 25, 2009

Appl. No.:

12/567135

Inventors:

John M. McCoy - Reading MA, US
Phillips W. Robbins - Cambridge MA, US

Assignee:

Glycosyn, Inc. - Medford MA

International Classification:

A61K 31/70
C12N 1/19
C12N 15/00
A61P 31/12

US Classification:

514 23, 4352542, 435440

Abstract:

The invention provides compositions and methods for engineering probiotic yeast to display α(1,2) fucosylated glycans on their cell surface, and the use thereof in the prevention or treatment of infection.

US Patent:

51889617, Feb 23, 1993

Filed:

Feb 1, 1990

Appl. No.:

7/473309

Inventors:

Karen M. Overbye - Stoneham MA
Janice Pero - Lexington MA
Phillips W. Robbins - Beverly MA

Assignee:

Omnigene, Inc. - Cambridge MA

International Classification:

C12N 1574
C12N 1552
C12N 121

US Classification:

43525231

Abstract:

Engineered DNA encoding a pre-protein which comprises a Streptomyces chitinase signal sequence and a desired mature protein. Preferably, the signal sequence is from the S. plicatus endochitinase gene. The engineered DNA is included in a host organism causing the host to produce and secrete the mature protein. Where the mature protein is a chitinase, the invention is used in methods of controlling chitinase-sensitive pests.

US Patent:

62039997, Mar 20, 2001

Filed:

Jan 14, 1999

Appl. No.:

9/231004

Inventors:

Phillips W. Robbins - Acton MA
Sadhana Prakash - Cambridge MA

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 33567

US Classification:

435 721

Abstract:

A process for assaying for cancer of the prostate, comprising assaying a sample derived from a human for prostate specific antigen having a linked oligosaccharide which is at least triantennary. The assay may employ a binding molecule which binds to oligosaccharides that are at least triantennary, but does not bind to oligosaccharides that are monoantennary or diantennary. Such binding molecule may be a lectin such as PHA-L or an antibody to an oligosaccharide that is at least triantennary.

US Patent:

59027258, May 11, 1999

Filed:

Jul 2, 1997

Appl. No.:

8/887468

Inventors:

Phillips W. Robbins - Acton MA
Sadhana Prakash - Cambridge MA

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N33/53

US Classification:

435 71

Abstract:

A process for assaying for cancer of the prostate, comprising assaying a sample derived from a human for prostate specific antigen having a linked oligosaccharide which is at least triantennary. The assay may employ a binding molecule which binds to oligosaccharides that are at least triantennary, but does not bind to oligosaccharides that are monoantennary or diantennary. Such binding molecule may be a lectin such as PHA-L or an antibody to an oligosaccharide that is at least triantennary.

US Patent:

47450568, May 17, 1988

Filed:

Oct 23, 1984

Appl. No.:

6/663842

Inventors:

Sonia Guterman - Belmont MA
Janice Pero - Lexington MA
Phillips Robbins - Arlington MA

Assignee:

Biotechnica International, Inc. - Cambridge MA

International Classification:

C12P 2100
C12N 1500
C12N 120
C12N 700

US Classification:

435 68

Abstract:

Cloning vectors are disclosed to obtain secretion of a desired protein from a host Streptomyces when a structural gene coding for the protein is inserted into the vector. The vector has: (1) regulatory DNA that includes a promoter sequence effective to start transcription in the host Streptomyces and DNA that encodes a ribosome-binding site; (2) a DNA sequence that codes for a signal sequence that occurs naturally in a Streptomyces strain or that derives from such a DNA sequence; and (3) at least one engineered restriction endonuclease recognition site positioned for the insertion of a structural gene, the DNA that encodes a signal sequence and attached structural gene being transcribed and translated together under the control of the regulatory DNA. Expression vectors are disclosed which include a structural gene coding for a desired protein so positioned. Streptomyces cells containing the vector and methods of using them to produce the desired protein are disclosed.