Pierre C Trepagnier

US Patent:

6559412, May 6, 2003

Filed:

Oct 2, 2001

Appl. No.:

09/968541

Inventors:

William Lauer - Westford MA 01886
Pierre Trepagnier - Medford MA 02155
Donald Victor Smart - Boston MA 02110
James Cordingley - Littleton MA 01460
Michael Plotkin - Newton MA 02165

International Classification:

B23K 2600

US Classification:

21912169, 21912168

Abstract:

The invention provides a system and method for vaporizing a target structure on a substrate. According to the invention, a calculation is performed, as a function of wavelength, of an incident beam energy necessary to deposit unit energy in the target structure. Then, for the incident beam energy, the energy expected to be deposited in the substrate as a function of wavelength is calculated. A wavelength is identified that corresponds to a relatively low value of the energy expected to be deposited in the substrate, the low value being substantially less than a value of the energy expected to be deposited in the substrate at a higher wavelength. A laser system is provided configured to produce a laser output at the wavelength corresponding to the relatively low value of the energy expected to be deposited in the substrate. The laser output is directed at the target structure on the substrate at the wavelength corresponding to the relatively low value of the energy expected to be deposited in the substrate, in order to vaporize the target structure.

US Patent:

6597932, Jul 22, 2003

Filed:

Feb 20, 2001

Appl. No.:

09/785549

Inventors:

Wei Dong Tian - West Roxbury MA
Pierre Trepagnier - Medford MA

Assignee:

Argose, Inc. - Waltham MA

International Classification:

A61B 500

US Classification:

600317

Abstract:

An instrument for evaluating fluorescence of a heterogeneous tissue includes means for exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths, means for collecting emission radiation from the two-dimensional portion of the tissue surface simultaneously with excitation of the portion, and means for forming a two-dimensional excitation-emission map of the excitation radiation and the simultaneously collected emission radiation and spatially averaging the excitation and emission radiation.

US Patent:

6639668, Oct 28, 2003

Filed:

Nov 3, 2000

Appl. No.:

09/704829

Inventors:

Pierre Trepagnier - Medford MA

Assignee:

Argose, Inc. - Waltham MA

International Classification:

G01J 330

US Classification:

356317, 2004581, 2004591, 2004611, 2004612

Abstract:

The present invention is directed to asynchronous scanning devices and methods of using asynchronous scanning to acquire fluorescence data from a sample, such as biological tissue, to facilitate diagnosis of the presence or absence of disease or other abnormality in the sample. The present invention is useful for biomedical diagnostics, chemical analysis or other evaluation of the target sample.

US Patent:

6721582, Apr 13, 2004

Filed:

Feb 20, 2001

Appl. No.:

09/785547

Inventors:

Pierre Trepagnier - Medford MA
Jenny Freeman - Weston MA
James Mansfield - Boston MA
Derek Brand - Brighton MA
Michael J. Hopmeier - Mary Ester FL
Nikiforos Kollias - Skillman NJ

Assignee:

Argose, Inc. - Waltham MA

International Classification:

A61B 500

US Classification:

600316, 600317

Abstract:

Instruments and methods are described for performing non-invasive measurements of analyte levels and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.

US Patent:

6911622, Jun 28, 2005

Filed:

May 5, 2003

Appl. No.:

10/428938

Inventors:

William Lauer - Westford MA, US
Pierre Trepagnier - Medford MA, US
Donald Victor Smart - Boston MA, US
James Cordingley - Littleton MA, US
Michael Plotkin - Newton MA, US

Assignee:

General Scanning, Inc. - Billerica MA

International Classification:

B23K026/00

US Classification:

21912169, 21912168

Abstract:

The invention provides a system and method for vaporizing a target structure on a substrate. According to the invention, a calculation is performed, as a function of wavelength, of an incident beam energy necessary to deposit unit energy in the target structure. Then, for the incident beam energy, the energy expected to be deposited in the substrate as a function of wavelength is calculated. A wavelength is identified that corresponds to a relatively low value of the energy expected to be deposited in the substrate, the low value being substantially less than a value of the energy expected to be deposited in the substrate at a higher wavelength. A laser system is provided configured to produce a laser output at the wavelength corresponding to the relatively low value of the energy expected to be deposited in the substrate. The laser output is directed at the target structure on the substrate at the wavelength corresponding to the relatively low value of the energy expected to be deposited in the substrate, in order to vaporize the target structure.

US Patent:

7088495, Aug 8, 2006

Filed:

May 30, 2003

Appl. No.:

10/449236

Inventors:

Pierre C. Trepagnier - Medford MA, US
Philip D. Henshaw - Carlisle MA, US
Robert F. Dillon - Stoneham MA, US

Assignee:

Sparta, Inc. - Lake Forest CA
Lumen Laboratories, Inc. - Burlington MA

International Classification:

G02F 1/35
H04J 14/08

US Classification:

359326, 398 52, 398 98

Abstract:

The present invention generally provides systems and methods for distribution of radiation among a plurality of optical channels, each of which can include a non-linear optical element. An optical system of the invention can include a source for generating radiation and an optical time-division multiplexer that can deflect, at any given time interval, the radiation into one of a plurality of optical channels.

US Patent:

7525102, Apr 28, 2009

Filed:

Oct 2, 2006

Appl. No.:

11/541935

Inventors:

Philip D. Henshaw - Carlisle MA, US
Pierre C. Trepagnier - Medford MA, US

Assignee:

Sparta, Inc. - Billerica MA

International Classification:

G01J 3/28

US Classification:

250393, 2504581, 2504591

Abstract:

The present invention generally provides systems and methods for detection of agents of interest in a bulk quantity of matter, which also contains clutter and other constituents that typically interfere with the detection of one or more agents of interest. A detection system of the invention generally contains a collection subsystem for obtaining a bulk sample, an interrogation subsystem for generating one or more analytical signals representative of the composition of the bulk sample, and an analytical subsystem according to the teachings of the invention that implements the methods and algorithms of the invention for analyzing the sample analytical signals to determine whether one or more agents of interest are present, e. g. , at quantities above a certain threshold, in the bulk sample.

US Patent:

7899518, Mar 1, 2011

Filed:

Sep 12, 2005

Appl. No.:

11/224690

Inventors:

Pierre Trepagnier - Medford MA, US
Jenny Freeman - Weston MA, US
James Mansfield - Boston MA, US
Derek Brand - Brighton MA, US
Michael J. Hopmeier - Mary Ester FL, US
Nikiforos Kollias - Skillman NJ, US

Assignee:

Masimo Laboratories, Inc. - Irvine CA

International Classification:

A61B 5/00

US Classification:

600473, 600476

Abstract:

Instruments and methods are described for performing non-invasive measurements of analyte levels and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.