Ping Cai - New City NY, US Mark Ruppen - Garnerville NY, US Russ Tsao - Tenafly NJ, US
Assignee:
Wyeth - Madison NJ
International Classification:
C07D 498/22
US Classification:
540456
Abstract:
A method of generating synthetic metabolites of CCI-779 is provided. Five novel CCI-779 derivatives are described, as are methods of using these derivatives for detecting CCI-779 metabolites in samples.
Process For Preparing Rapamycin 42-Esters And Fk-506 32-Esters With Dicarboxylic Acid, Precursors For Rapamycin Conjugates And Antibodies
Jianxin Gu - River Edge NJ, US Ping Cai - New City NY, US Mark E. Ruppen - Garnerville NY, US
Assignee:
Wyeth - Madison NJ
International Classification:
C12P 17/16 C12P 17/18
US Classification:
435118, 435119
Abstract:
Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids is described. The methods involve catalyzing the reaction between a rapamycin or a FK-506 and a dicarboxylic anhydride or a bifunctional activated ester of dicarboxylic acid with a lipase.
Process For Preparing Rapamycin 42-Esters And Fk-506 32-Esters With Dicarboxylic Acid, Precursors For Rapamycin Conjugates And Antibodies
Jianxin Gu - River Edge NJ, US Ping Cai - New City NY, US Mark E. Ruppen - Garnerville NY, US
Assignee:
Wyeth - Madison NJ
International Classification:
C12P 17/16 C12P 17/18
US Classification:
435118, 435119
Abstract:
Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids is described. The methods involve catalyzing the reaction between a rapamycin or a FK-506 and a dicarboxylic anhydride or a bifunctional activated ester of dicarboxylic acid with a lipase.
Analogs Of 17-Hydroxywortmannin As Pi3K Inhibitors
Arie Zask - New York NY, US Ping Cai - New City NY, US Jianxin Gu - River Edge NJ, US Joshua Kaplan - Nyack NY, US Ker Yu - Pine Brook NJ, US Tianmin Zhu - Monroe NY, US
Assignee:
Wyeth - Madison NJ
International Classification:
A61K 31/352 C07D 311/94
US Classification:
514453, 549276
Abstract:
The present invention relates to compounds of formula I:.
Regiospecific Synthesis Of Rapamycin 42-Ester Derivatives
Jianxin Gu - River Edge NJ, US Ping Cai - New City NY, US Mark E. Ruppen - Garnerville NY, US
Assignee:
Wyeth - Madison NJ
International Classification:
C07D 498/18 A61K 31/395
US Classification:
514291, 540456
Abstract:
A method for the regiospecific synthesis of rapamycin 42-ester derivatives is described. The method involves lipase-catalyzed acetylation of 42-hydroxy of rapamycin with an acyl donor such as a vinyl ester, an isopropenyl ester or an anhydride in a suitable organic solvent.
This disclosure describes antifungal antibiotics designated Hygroscopene A, Hygroscopene B and Hygroscopene C to their production by fermentation, to methods for recovery and concentration from the crude solutions, to a process for purification and to new analogs of Hygroscopene A, Hygroscopene B and Hygroscopene C prepared by synthetic procedures.
Krishnendu Ghosh - Sparkill NY, US Arwinder Nagi - Thiells NY, US Xiaohong Pan - Highland Mills NY, US Melissa Lin - Wanaque NY, US Leonid Linberg - Upper Saddle River NJ, US Ping Cai - New City NY, US Eric Browne - Pierrefonds, CA Michel Bernatchez - Montreal, CA Mark Lankau - Dollard des Ormeaux, CA
International Classification:
A61K031/496 C07D045/14
US Classification:
514252110, 544357000
Abstract:
This invention relates to, for example, novel formulations and methods for the delivery of 4-cyano-N-{(2R)-2-[4-(2,3-dihydro-benzo[1,4]dioxin-5yl)-piperazin-1-yl]-propyl}-N-pyridin-2-yl-benzamide, pharmaceutically acceptable salts thereof, structurally related compounds and/or metabolites; as well as to use of these formulations and methods for treating disease.
Krishnendu Ghosh - Sparkill NY, US Arwinder Nagi - Thiells NY, US Xiaohong Pan - Highland Mills NY, US Melissa Lin - Wanaque NJ, US Leonid Linberg - Upper Saddle River NJ, US Ping Cai - New City NY, US Eric Browne - Quebec, CA Michel Bernatchez - Montreal, CA Mark Lankau - Dollard des Ormeaux, CA Sangeeta Raje - Audubon PA, US
Assignee:
Wyeth - Madison NJ
International Classification:
A61K 31/496
US Classification:
514253110
Abstract:
The invention relates to, for example, novel formulations and methods for the delivery of 4-cyano-N-{(2R)—2-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-propyl}-N-pyridin-2-yl-benzamide, pharmaceutically acceptable salts thereof, structurally related compounds and/or metabolites; as well as to use of these formulations and methods for treating disease.
License Records
Ping Cai
License #:
21408 - Active
Category:
Architect
Issued Date:
Jun 2, 2009
Expiration Date:
Nov 30, 2017
Organization:
Firm Not Published
Ping Cai
License #:
57571 - Active
Category:
Professional
Issued Date:
Apr 22, 2014
Expiration Date:
Mar 31, 2020
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